Current status of interspecies somatic cell nuclear transfer and meta-analysis of the effects of phylogenetic distance on embryonic and fetal development

IF 4.3 2区 生物学 Q1 ECOLOGY Mammal Review Pub Date : 2024-04-03 DOI:10.1111/mam.12352
Laura Adams, Ying Liu, Irina A. Polejaeva
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种间体细胞核移植的现状以及系统发育距离对胚胎和胎儿发育影响的荟萃分析
种间体细胞核移植(iSCNT)能够拯救濒危物种,符合伦理道德地生产人类胚胎干细胞,并能对植入前胚胎进行更具体的分析。然而,一些障碍对 iSCNT 的效率产生了负面影响。从1999年到2023年春季,已经发表了100多项iSCNT研究。本综述详细介绍了 iSCNT 可能带来的益处,描述了阻碍一些胚胎和/或活体后代发育的假设问题,并根据已发表的数据分析了裂解率、囊胚率、妊娠率、活产率和 iSCNT 效率。通过 iSCNT 生产的胚胎可能有助于拯救濒危物种,利用家养物种的卵母细胞生产人类胚胎干细胞,以及深入分析胚胎基因组激活(EGA)和 mRNA 转录本。但是,将两个物种的细胞结合到一个胚胎中会面临一些挑战:缺乏 EGA 同步性、胚胎中存在来自两个物种的线粒体 DNA(mtDNA)、每个物种组合都需要优化细胞和胚胎培养、缺乏胚胎移植数据,以及产生活后代的总体效率极低。为了提高 iSCNT 的效率,有必要对上述课题进行更多的研究。
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来源期刊
Mammal Review
Mammal Review 生物-动物学
CiteScore
12.20
自引率
4.10%
发文量
29
审稿时长
>12 weeks
期刊介绍: Mammal Review is the official scientific periodical of the Mammal Society, and covers all aspects of mammalian biology and ecology, including behavioural ecology, biogeography, conservation, ecology, ethology, evolution, genetics, human ecology, management, morphology, and taxonomy. We publish Reviews drawing together information from various sources in the public domain for a new synthesis or analysis of mammalian biology; Predictive Reviews using quantitative models to provide insights into mammalian biology; Perspectives presenting original views on any aspect of mammalian biology; Comments in response to papers published in Mammal Review; and Short Communications describing new findings or methods in mammalian biology.
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