The emerging role of CARM1 in cancer

IF 6.6 2区医学 Q1 Medicine Cellular Oncology Pub Date : 2024-04-15 DOI:10.1007/s13402-024-00943-9

Zizhuo Xie, Yuan Tian, Xiaohan Guo, Na Xie

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Abstract

Coactivator-associated arginine methyltransferase 1 (CARM1), pivotal for catalyzing arginine methylation of histone and non-histone proteins, plays a crucial role in developing various cancers. CARM1 was initially recognized as a transcriptional coregulator by orchestrating chromatin remodeling, transcription regulation, mRNA splicing and stability. This diverse functionality contributes to the recruitment of transcription factors that foster malignancies. Going beyond its established involvement in transcriptional control, CARM1-mediated methylation influences a spectrum of biological processes, including the cell cycle, metabolism, autophagy, redox homeostasis, and inflammation. By manipulating these physiological functions, CARM1 becomes essential in critical processes such as tumorigenesis, metastasis, and therapeutic resistance. Consequently, it emerges as a viable target for therapeutic intervention and a possible biomarker for medication response in specific cancer types. This review provides a comprehensive exploration of the various physiological functions of CARM1 in the context of cancer. Furthermore, we discuss potential CARM1-targeting pharmaceutical interventions for cancer therapy.

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CARM1 在癌症中的新作用

共激活子相关精氨酸甲基转移酶 1（CARM1）在催化组蛋白和非组蛋白的精氨酸甲基化方面起着关键作用，在各种癌症的发病过程中发挥着重要作用。CARM1 最初被认为是一种转录核心调节器，可协调染色质重塑、转录调节、mRNA 剪接和稳定性。这种多样化的功能有助于转录因子的招募，从而诱发恶性肿瘤。CARM1 介导的甲基化不仅参与转录调控，还影响一系列生物过程，包括细胞周期、新陈代谢、自噬、氧化还原平衡和炎症。通过操纵这些生理功能，CARM1 在肿瘤发生、转移和抗药性等关键过程中变得至关重要。因此，CARM1 成为治疗干预的可行靶点，并可能成为特定癌症类型中药物反应的生物标志物。本综述全面探讨了 CARM1 在癌症中的各种生理功能。此外，我们还讨论了潜在的以 CARM1 为靶点的癌症治疗药物干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

10.40

自引率

1.50%

发文量

审稿时长

16 weeks

期刊介绍： The Official Journal of the International Society for Cellular Oncology Focuses on translational research Addresses the conversion of cell biology to clinical applications Cellular Oncology publishes scientific contributions from various biomedical and clinical disciplines involved in basic and translational cancer research on the cell and tissue level, technical and bioinformatics developments in this area, and clinical applications. This includes a variety of fields like genome technology, micro-arrays and other high-throughput techniques, genomic instability, SNP, DNA methylation, signaling pathways, DNA organization, (sub)microscopic imaging, proteomics, bioinformatics, functional effects of genomics, drug design and development, molecular diagnostics and targeted cancer therapies, genotype-phenotype interactions. A major goal is to translate the latest developments in these fields from the research laboratory into routine patient management. To this end Cellular Oncology forms a platform of scientific information exchange between molecular biologists and geneticists, technical developers, pathologists, (medical) oncologists and other clinicians involved in the management of cancer patients. In vitro studies are preferentially supported by validations in tumor tissue with clinicopathological associations.