The role of vasculature and angiogenesis in respiratory diseases

IF 9.2 1区 医学 Q1 PERIPHERAL VASCULAR DISEASE Angiogenesis Pub Date : 2024-04-05 DOI:10.1007/s10456-024-09910-2
Maximilian Ackermann, Christopher Werlein, Edith Plucinski, Sophie Leypold, Mark P. Kühnel, Stijn E. Verleden, Hassan A. Khalil, Florian Länger, Tobias Welte, Steven J. Mentzer, Danny D. Jonigk
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Abstract

In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension, IPF or lung cancer. The contribution of blood vessels and angiogenesis to lung regeneration, remodeling and disease progression has been increasingly appreciated. The vascular supply of the lung shows the peculiarity of dual perfusion of the pulmonary circulation (vasa publica), which maintains a functional blood-gas barrier, and the bronchial circulation (vasa privata), which reveals a profiled capacity for angiogenesis (namely intussusceptive and sprouting angiogenesis) and alveolar-vascular remodeling by the recruitment of endothelial precursor cells. The aim of this review is to outline the importance of vascular remodeling and angiogenesis in a variety of non-neoplastic and neoplastic acute and chronic respiratory diseases such as lung infection, COPD, lung fibrosis, pulmonary hypertension and lung cancer.

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血管和血管生成在呼吸系统疾病中的作用
在欧洲国家,近 10%的住院病人与呼吸系统疾病有关,主要是慢性阻塞性肺病、肺动脉高压、IPF 或肺癌等危及生命的慢性疾病。血管和血管生成对肺再生、重塑和疾病进展的贡献日益受到重视。肺部血管供应具有双重灌注的特点,即肺循环(公共血管)和支气管循环(私人血管),前者维持着功能性血气屏障,后者则通过招募内皮前体细胞,显示出血管生成(即肠内血管生成和发芽血管生成)和肺泡血管重塑的能力。本综述旨在概述血管重塑和血管生成在各种非肿瘤性和肿瘤性急慢性呼吸系统疾病(如肺部感染、慢性阻塞性肺病、肺纤维化、肺动脉高压和肺癌)中的重要性。
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来源期刊
Angiogenesis
Angiogenesis PERIPHERAL VASCULAR DISEASE-
CiteScore
21.90
自引率
8.20%
发文量
37
审稿时长
6-12 weeks
期刊介绍: Angiogenesis, a renowned international journal, seeks to publish high-quality original articles and reviews on the cellular and molecular mechanisms governing angiogenesis in both normal and pathological conditions. By serving as a primary platform for swift communication within the field of angiogenesis research, this multidisciplinary journal showcases pioneering experimental studies utilizing molecular techniques, in vitro methods, animal models, and clinical investigations into angiogenic diseases. Furthermore, Angiogenesis sheds light on cutting-edge therapeutic strategies for promoting or inhibiting angiogenesis, while also highlighting fresh markers and techniques for disease diagnosis and prognosis.
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