Enhancing the functionality of biodegradable Mg–Zn–Mn alloys using poly(lactic) acid (PLA) coating for temporary implants

IF 2.3 4区材料科学 Q2 CHEMISTRY, APPLIED Journal of Coatings Technology and Research Pub Date : 2024-04-01 DOI:10.1007/s11998-024-00913-8

Prakash Kumar, Gajanan Anne, M. R. Ramesh, Mrityunjay Doddamani, Ashwini Prabhu

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Abstract

Polylactic acid (PLA) was coated on biodegradable Mg–Zn–Mn alloys using a sol–gel coating technique for temporary implant applications. The presence of smooth, dense, crack-free PLA coating was evidenced using Fourier transform infrared spectroscopy (FTIR) and a scanning electronic microscope (SEM) equipped with an energy-dispersive X-ray spectroscopy (EDX) module. The strength of the bond between PLA and the Mg–Zn–Mn alloys was investigated as per ASTM D3359 and found to be 4B. The degradation behavior was evaluated using potentiodynamic polarization and electrochemical impedance spectroscopy in a simulated body fluid (SBF) solution. The corrosion rate of the PLA–Mg–Zn–Mn sample was found to be 0.00363 mm/y, which is 73% better than the bare Mg–Zn–Mn sample (0.00493 mm/y). In addition, the results of the cytotoxicity assay indicated the cytocompatibility of the implant material on MG-63 osteoblast-like cells, confirming its safety on the bone cells. The efficacy of the use of PLA coating on the biodegradable Mg–Zn–Mn is due to the synergistic effect of both physical and chemical interactions between the PLA layer and the substrate.

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利用聚乳酸（PLA）涂层增强生物可降解镁锌锰合金的功能，用于临时植入物

利用溶胶-凝胶涂层技术在可生物降解的镁锌锰合金上涂覆了聚乳酸（PLA），用于临时植入物。使用傅立叶变换红外光谱仪（FTIR）和配备能量色散 X 射线光谱仪（EDX）模块的扫描电子显微镜（SEM）证明了聚乳酸涂层的光滑、致密和无裂纹。根据 ASTM D3359 标准对聚乳酸和镁锌锰合金之间的结合强度进行了调查，结果显示结合强度为 4B。在模拟体液（SBF）溶液中，使用电位极化和电化学阻抗光谱法对降解行为进行了评估。发现聚乳酸-镁-锌-锰样品的腐蚀速率为 0.00363 mm/y，比裸镁-锌-锰样品（0.00493 mm/y）好 73%。此外，细胞毒性实验结果表明，该植入材料对 MG-63 骨细胞具有细胞相容性，证实了其对骨细胞的安全性。在可生物降解的镁锌锰上使用聚乳酸涂层之所以有效，是因为聚乳酸层与基底之间的物理和化学作用产生了协同效应。

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来源期刊

Journal of Coatings Technology and Research 工程技术-材料科学：膜

CiteScore

4.30

自引率

8.70%

发文量

130

审稿时长

2.5 months

期刊介绍： Journal of Coatings Technology and Research (JCTR) is a forum for the exchange of research, experience, knowledge and ideas among those with a professional interest in the science, technology and manufacture of functional, protective and decorative coatings including paints, inks and related coatings and their raw materials, and similar topics.