Automated protocols for delineating human hippocampal subfields from 3 Tesla and 7 Tesla magnetic resonance imaging data

IF 2.4 3区 医学 Q3 NEUROSCIENCES Hippocampus Pub Date : 2024-04-09 DOI:10.1002/hipo.23606
Alice L. Hickling, Ian A. Clark, Yan I. Wu, Eleanor A. Maguire
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Abstract

Researchers who study the human hippocampus are naturally interested in how its subfields function. However, many researchers are precluded from examining subfields because their manual delineation from magnetic resonance imaging (MRI) scans (still the gold standard approach) is time consuming and requires significant expertise. To help ameliorate this issue, we present here two protocols, one for 3T MRI and the other for 7T MRI, that permit automated hippocampus segmentation into six subregions, namely dentate gyrus/cornu ammonis (CA)4, CA2/3, CA1, subiculum, pre/parasubiculum, and uncus along the entire length of the hippocampus. These protocols are particularly notable relative to existing resources in that they were trained and tested using large numbers of healthy young adults (n = 140 at 3T, n = 40 at 7T) whose hippocampi were manually segmented by experts from MRI scans. Using inter-rater reliability analyses, we showed that the quality of automated segmentations produced by these protocols was high and comparable to expert manual segmenters. We provide full open access to the automated protocols, and anticipate they will save hippocampus researchers a significant amount of time. They could also help to catalyze subfield research, which is essential for gaining a full understanding of how the hippocampus functions.

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从 3 特斯拉和 7 特斯拉磁共振成像数据中划分人类海马亚区的自动规程
研究人类海马的研究人员自然会对其子场的功能感兴趣。然而,由于从磁共振成像(MRI)扫描(仍是黄金标准方法)中手动划分亚场耗时且需要大量专业知识,许多研究人员无法对亚场进行检查。为了帮助改善这一问题,我们在此提出了两个方案,一个用于 3T MRI,另一个用于 7T MRI,这两个方案允许自动将海马分割成六个亚区,即齿状回/胼胝体(CA)4、CA2/3、CA1、亚丘、前/副胼胝体和海马全长的胼胝体。与现有资源相比,这些方案尤其值得注意的是,它们是通过大量健康的年轻人(3T 时为 140 人,7T 时为 40 人)进行训练和测试的,这些年轻人的海马是由专家通过核磁共振扫描手动分割的。我们使用评分者间可靠性分析表明,这些方案产生的自动分割质量很高,可与专家人工分割相媲美。我们提供对自动程序的完全开放访问权限,预计它们将为海马研究人员节省大量时间。它们还有助于促进分领域研究,这对全面了解海马的功能至关重要。
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来源期刊
Hippocampus
Hippocampus 医学-神经科学
CiteScore
5.80
自引率
5.70%
发文量
79
审稿时长
3-8 weeks
期刊介绍: Hippocampus provides a forum for the exchange of current information between investigators interested in the neurobiology of the hippocampal formation and related structures. While the relationships of submitted papers to the hippocampal formation will be evaluated liberally, the substance of appropriate papers should deal with the hippocampal formation per se or with the interaction between the hippocampal formation and other brain regions. The scope of Hippocampus is wide: single and multidisciplinary experimental studies from all fields of basic science, theoretical papers, papers dealing with hippocampal preparations as models for understanding the central nervous system, and clinical studies will be considered for publication. The Editor especially encourages the submission of papers that contribute to a functional understanding of the hippocampal formation.
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