Prediction of deleterious non-synonymous SNPs of TMPRSS2 protein combined with Molecular Dynamics Simulations and free energy analysis to identify the potential peptide substrates against SARS-CoV-2

Balajee Ramachandran, Ahmed Nadeem, Aruchamy Mohanprasanth, Muthupandian Saravanan
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Abstract

Globally the SARS-CoV-2 viral infection demands for the new drugs, the TMPRSS2 target plays a vital role in facilitating the virus entry. The aim of the present study is to identify the potential p...
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预测 TMPRSS2 蛋白的有害非同义 SNPs,结合分子动力学模拟和自由能分析,确定抗 SARS-CoV-2 的潜在多肽底物
全球范围内的 SARS-CoV-2 病毒感染都需要新的药物,而 TMPRSS2 靶点在促进病毒进入方面起着至关重要的作用。本研究的目的是找出潜在的TMPRSS2靶点,并对其进行研究。
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