The Main Mechanisms of Mesenchymal Stem Cell-Based Treatments against COVID-19

IF 4.4 4区医学 Q2 CELL & TISSUE ENGINEERING Tissue engineering and regenerative medicine Pub Date : 2024-04-04 DOI:10.1007/s13770-024-00633-5

Jinling Li, Shipei He, Hang Yang, Lizeai Zhang, Jie Xiao, Chaoyi Liang, Sijia Liu

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Abstract

Background

Coronavirus disease 2019 (COVID-19) has a clinical manifestation of hypoxic respiratory failure and acute respiratory distress syndrome. However, COVID-19 still lacks of effective clinical treatments so far. As a promising potential treatment against COVID-19, stem cell therapy raised recently and had attracted much attention. Here we review the mechanisms of mesenchymal stem cell-based treatments against COVID-19, and provide potential cues for the effective control of COVID-19 in the future.

Methods

Literature is obtained from databases PubMed and Web of Science. Key words were chosen for COVID- 19, acute respiratory syndrome coronavirus 2, mesenchymal stem cells, stem cell therapy, and therapeutic mechanism. Then we summarize and critically analyze the relevant articles retrieved.

Results

Mesenchymal stem cell therapy is a potential effective treatment against COVID-19. Its therapeutic efficacy is mainly reflected in reducing severe pulmonary inflammation, reducing lung injury, improving pulmonary function, protecting and repairing lung tissue of the patients. Possible therapeutic mechanisms might include immunoregulation, anti-inflammatory effect, tissue regeneration, anti-apoptosis effect, antiviral, and antibacterial effect, MSC - EVs, and so on.

Conclusion

Mesenchymal stem cells can effectively treat COVID-19 through immunoregulation, anti-inflammatory, tissue regeneration, anti-apoptosis, anti-virus and antibacterial, MSC - EVs, and other ways. Systematically elucidating the mechanisms of mesenchymal stem cell-based treatments for COVID-19 will provide novel insights into the follow-up research and development of new therapeutic strategies in next step.

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间充质干细胞治疗 COVID-19 的主要机制

背景科罗纳病毒病 2019（COVID-19）的临床表现为缺氧性呼吸衰竭和急性呼吸窘迫综合征。然而，COVID-19至今仍缺乏有效的临床治疗方法。干细胞疗法作为一种有望治疗COVID-19的潜在疗法，近年来备受关注。在此，我们回顾了基于间充质干细胞的COVID-19治疗机制，并为未来有效控制COVID-19提供潜在线索。选取的关键词包括COVID-19、急性呼吸综合征冠状病毒2、间充质干细胞、干细胞疗法和治疗机制。结果间充质干细胞疗法是治疗 COVID-19 的一种潜在有效方法。其疗效主要体现在减轻严重的肺部炎症、减轻肺损伤、改善肺功能、保护和修复患者的肺组织。结论间充质干细胞可通过免疫调节、抗炎、组织再生、抗凋亡、抗病毒、抗菌、间充质干细胞-EVs等途径有效治疗COVID-19。系统阐明间充质干细胞治疗COVID-19的机制将为下一步的后续研究和开发新的治疗策略提供新的见解。

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来源期刊

Tissue engineering and regenerative medicine CELL & TISSUE ENGINEERING-ENGINEERING, BIOMEDICAL

CiteScore

6.80

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Tissue Engineering and Regenerative Medicine (Tissue Eng Regen Med, TERM), the official journal of the Korean Tissue Engineering and Regenerative Medicine Society, is a publication dedicated to providing research- based solutions to issues related to human diseases. This journal publishes articles that report substantial information and original findings on tissue engineering, medical biomaterials, cells therapy, stem cell biology and regenerative medicine.