Surfactant Proteins SP-A and SP-D and Conventional Risk Factors for Chronic Noncommunicable Human Diseases

Q4 Biochemistry, Genetics and Molecular Biology Cell and Tissue Biology Pub Date : 2024-04-15 DOI:10.1134/s1990519x2370013x

K. Yu. Nikolaev, O. S. Kharlamova, I. A. Kosarev, N. F. Dadashova, Y. K. Lapitskay

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Abstract

Surfactant proteins SP-A and SP-D, members of the type C collagen-containing lectin family, are used as diagnostic and prognostic markers for many acute and chronic diseases of the bronchopulmonary system. The aim of the study was to assess the influence of conventional risk factors for chronic noncommunicable diseases on the level of surfactant proteins SP-A and SP-D through a system-structural analysis based on current publications from international databases and official WHO reports. Based on the results of the analytical review, it is concluded that widespread expression of SP-A and SP-D have been documented in numerous studies, and, although the lung remains the main site of the synthesis of surfactant protein, they can be expected to have a significant influence on the immune and inflammatory response in many organs and tissues. The authors note that a number of extrapulmonary effects of these proteins are known. However, many mechanisms of additional cellular effects of SP-A and SP-D outside the bronchopulmonary system still remain unexplored, which indicates the promise of further research in this area.

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表面活性蛋白 SP-A 和 SP-D 与人类慢性非传染性疾病的常规风险因素

摘要表面活性蛋白SP-A和SP-D是含C型胶原凝集素家族的成员，被用作许多支气管肺系统急慢性疾病的诊断和预后标志物。本研究的目的是通过系统结构分析，评估慢性非传染性疾病的常规风险因素对表面活性蛋白SP-A和SP-D水平的影响，该分析以国际数据库中的现有出版物和世界卫生组织的官方报告为基础。根据分析综述的结果，作者得出结论认为，许多研究都记录了 SP-A 和 SP-D 的广泛表达，尽管肺仍然是合成表面活性物质蛋白的主要场所，但预计它们会对许多器官和组织的免疫和炎症反应产生重大影响。作者指出，这些蛋白质的一些肺外效应是已知的。然而，SP-A 和 SP-D 在支气管肺系统之外对细胞产生额外影响的许多机制仍有待探索，这表明这一领域的研究大有可为。

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来源期刊

Cell and Tissue Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

0.80

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0.00%

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期刊介绍： The journal publishes papers on vast aspects of cell research, including morphology, biochemistry, biophysics, genetics, molecular biology, immunology. The journal accepts original experimental studies, theoretical articles suggesting novel principles and approaches, presentations of new hypotheses, reviews highlighting major developments in cell biology, discussions. The main objective of the journal is to provide a competent representation and integration of research made on cells (animal and plant cells, both in vivo and in cell culture) offering insight into the structure and functions of live cells as a whole. Characteristically, the journal publishes articles on biology of free-living and parasitic protists, which, unlike Metazoa, are eukaryotic organisms at the cellular level of organization.