L. A. Miroshnichenko, T. Yu. Polyakova, L. S. Litvinova, I. A. Khlusov
{"title":"Review of Local Cellular and Molecular Processes of Bone Tissue Regeneration Induced by Calcium Phosphate Materials","authors":"L. A. Miroshnichenko, T. Yu. Polyakova, L. S. Litvinova, I. A. Khlusov","doi":"10.1134/s1990519x23700062","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>One of the leading causes of hospitalization, disability, and mortality in 50% of women and 20% of men in age group over 50 years of age is bone fractures and their complications caused by diseases musculoskeletal system. There is an active search for a solution to the problem associated with the limitations of using auto-, allo-, and xenografts in the clinic to replace bone defects initiated the development a regenerative approach based on the gradual replacement of artificial material with growing bone tissue. Promise is presented in this regard by materials based on calcium phosphates, which act as an active source of chemical elements (calcium, phosphorus, etc.) capable of optimizing the process of healing of a bone defect and ensuring the replacement of an implant with new bone tissue. This review summarizes data from the literature on the local biological activity, target cells, and molecular effects of calcium phosphates. Calcium phosphate materials have been shown to be biocompatible and are able to adsorb regulatory proteins and cells, influencing their genetic and secretory apparatus and triggering the process of differentiation of mesenchymal stem cells in the osteogenic direction. At the same time, the successful implementation of local mechanisms of osseointegration at the bone–implant interface reduces the risk of periprosthetic infection and rejection of artificial products. Further study and use of calcium phosphate materials will make it possible to make a significant breakthrough in solving modern problems of bone tissue regeneration associated with a precise (digital) bioengineering approach based on additive technologies and artificial intelligence.</p>","PeriodicalId":9705,"journal":{"name":"Cell and Tissue Biology","volume":"28 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell and Tissue Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s1990519x23700062","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
One of the leading causes of hospitalization, disability, and mortality in 50% of women and 20% of men in age group over 50 years of age is bone fractures and their complications caused by diseases musculoskeletal system. There is an active search for a solution to the problem associated with the limitations of using auto-, allo-, and xenografts in the clinic to replace bone defects initiated the development a regenerative approach based on the gradual replacement of artificial material with growing bone tissue. Promise is presented in this regard by materials based on calcium phosphates, which act as an active source of chemical elements (calcium, phosphorus, etc.) capable of optimizing the process of healing of a bone defect and ensuring the replacement of an implant with new bone tissue. This review summarizes data from the literature on the local biological activity, target cells, and molecular effects of calcium phosphates. Calcium phosphate materials have been shown to be biocompatible and are able to adsorb regulatory proteins and cells, influencing their genetic and secretory apparatus and triggering the process of differentiation of mesenchymal stem cells in the osteogenic direction. At the same time, the successful implementation of local mechanisms of osseointegration at the bone–implant interface reduces the risk of periprosthetic infection and rejection of artificial products. Further study and use of calcium phosphate materials will make it possible to make a significant breakthrough in solving modern problems of bone tissue regeneration associated with a precise (digital) bioengineering approach based on additive technologies and artificial intelligence.
期刊介绍：
The journal publishes papers on vast aspects of cell research, including morphology, biochemistry, biophysics, genetics, molecular biology, immunology. The journal accepts original experimental studies, theoretical articles suggesting novel principles and approaches, presentations of new hypotheses, reviews highlighting major developments in cell biology, discussions. The main objective of the journal is to provide a competent representation and integration of research made on cells (animal and plant cells, both in vivo and in cell culture) offering insight into the structure and functions of live cells as a whole. Characteristically, the journal publishes articles on biology of free-living and parasitic protists, which, unlike Metazoa, are eukaryotic organisms at the cellular level of organization.
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