Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development

IF 11.4 1区 生物学 Q1 CELL BIOLOGY Annual review of cell and developmental biology Pub Date : 2024-04-12 DOI:10.1146/annurev-cellbio-120123-105748
Hong Huang, Shaorong Gao, Min Bao
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Abstract

Embryonic development is a dynamic process orchestrated by a delicate interplay of biochemical and biophysical factors. While the role of genetics and biochemistry in embryogenesis has been extensively studied, recent research has highlighted the significance of mechanical regulation in shaping and guiding this intricate process. Here, we provide an overview of the current understanding of the mechanical regulation of embryo development. We explore how mechanical forces generated by cells and tissues play a crucial role in driving the development of different stages. We examine key morphogenetic processes such as compaction, blastocyst formation, implantation, and egg cylinder formation, and discuss the mechanical mechanisms and cues involved. By synthesizing the current body of literature, we highlight the emerging concepts and open questions in the field of mechanical regulation. We aim to provide an overview of the field, inspiring future investigations and fostering a deeper understanding of the mechanical aspects of embryo development.
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探索胚胎早期发育过程中塑造自我组织和形态发生的机械力
胚胎发育是一个由生物化学和生物物理因素微妙相互作用的动态过程。虽然遗传学和生物化学在胚胎发生中的作用已被广泛研究,但最近的研究强调了机械调控在塑造和引导这一复杂过程中的重要性。在此,我们概述了目前对胚胎发育机械调控的理解。我们探讨了细胞和组织产生的机械力如何在驱动不同阶段的发育过程中发挥关键作用。我们研究了压实、囊胚形成、植入和卵圆柱形成等关键形态发生过程,并讨论了其中涉及的机械机制和线索。通过综合现有文献,我们强调了机械调控领域的新兴概念和未决问题。我们的目标是提供该领域的概况,启发未来的研究,促进对胚胎发育机械方面的更深入了解。
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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
期刊最新文献
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