The association of the prothrombin A19911G single-nucleotide polymorphism and the risk of venous thromboembolism: A systematic review and meta-analysis
{"title":"The association of the prothrombin A19911G single-nucleotide polymorphism and the risk of venous thromboembolism: A systematic review and meta-analysis","authors":"Kehong Xiang, Huan Xu, Yamei Zhang, Qiuju Leng, Feng Zhang","doi":"10.1177/02683555241247095","DOIUrl":null,"url":null,"abstract":"BackgroundThe study employed meta-analysis to provide a comprehensive synthesis of evidence regarding the association between the prothrombin A19911G polymorphism and the risk of venous thromboembolism (VTE).MethodThe databases were searched to identify studies investigating the association between the prothrombin A19911G polymorphism and the risk of VTE. Meta-analysis was conducted using Stata 14.0 software.ResultsA total of five literature studies were included, involving 14,001 participants. Meta-analysis demonstrated that prothrombin A19911G polymorphism increased the risk of VTE (G vs A: OR = 1.17, 95% CI = 1.11–1.22, p < .00001; GG + AG vs AA: OR = 1.22, 95% CI = 1.13–1.31, p < .00001; GG vs AG + AA: OR = 1.23, 95% CI = 1.14–1.33, p < .00001; AG vs AA: OR = 1.15, 95% CI = 1.06–1.25, p = .0006; GG vs AA: OR = 1.34, 95% CI = 1.22–1.48, p < .00001).ConclusionThe polymorphism of prothrombin A19911G enhances the susceptibility to VTE.","PeriodicalId":519221,"journal":{"name":"Phlebology: The Journal of Venous Disease","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phlebology: The Journal of Venous Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/02683555241247095","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
BackgroundThe study employed meta-analysis to provide a comprehensive synthesis of evidence regarding the association between the prothrombin A19911G polymorphism and the risk of venous thromboembolism (VTE).MethodThe databases were searched to identify studies investigating the association between the prothrombin A19911G polymorphism and the risk of VTE. Meta-analysis was conducted using Stata 14.0 software.ResultsA total of five literature studies were included, involving 14,001 participants. Meta-analysis demonstrated that prothrombin A19911G polymorphism increased the risk of VTE (G vs A: OR = 1.17, 95% CI = 1.11–1.22, p < .00001; GG + AG vs AA: OR = 1.22, 95% CI = 1.13–1.31, p < .00001; GG vs AG + AA: OR = 1.23, 95% CI = 1.14–1.33, p < .00001; AG vs AA: OR = 1.15, 95% CI = 1.06–1.25, p = .0006; GG vs AA: OR = 1.34, 95% CI = 1.22–1.48, p < .00001).ConclusionThe polymorphism of prothrombin A19911G enhances the susceptibility to VTE.
研究背景该研究采用荟萃分析法对凝血酶原A19911G多态性与静脉血栓栓塞症（VTE）风险之间的关系进行了全面的证据综述。方法检索数据库，以确定凝血酶原A19911G多态性与VTE风险之间关系的研究。结果共纳入 5 项文献研究，涉及 14 001 名参与者。元分析表明，凝血酶原 A19911G 多态性会增加 VTE 风险（G vs A：OR = 1.17，95% CI = 1.11-1.22，p < .00001；GG + AG vs AA：OR = 1.22，95% CI = 1.13-1.31，p < .00001；GG vs AG + AA：OR = 1.23, 95% CI = 1.14-1.33, p < .00001; AG vs AA: OR = 1.15, 95% CI = 1.06-1.25, p = .0006; GG vs AA: OR = 1.34, 95% CI = 1.22-1.48, p < .00001)。
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