Gut microbiota plays a significant role in gout

IF 2.4 4区 医学 Q3 MICROBIOLOGY Journal of medical microbiology Pub Date : 2024-04-17 DOI:10.1099/jmm.0.001824
Zhi-Peng Feng, Xiao-Yan Wang, Hong-Yi Xin, Shao-Li Huang, Hong-Yu Huang, Qiang Xin, Xi-He Zhang and Hong-Wu Xin
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Abstract

With the development of social economy, the incidence of gout is increasing, which is closely related to people’s increasingly rich diet. Eating a diet high in purine, fat, sugar and low-fibre for a long time further aggravates gout by affecting uric acid metabolism. The renal metabolism mechanism of uric acid has been thoroughly studied. To find a new treatment method for gout, increasing studies have recently been conducted on the mechanism of intestinal excretion, metabolism and absorption of uric acid. The most important research is the relationship between intestinal microbiota and the risk of gout. Gut microbiota represent bacteria that reside in a host’s gastrointestinal tract. The composition of the gut microbiota is associated with protection against pathogen colonization and disease occurrence. This review focuses on how gut microbiota affects gout through uric acid and discusses the types of bacteria that may be involved in the occurrence and progression of gout. We also describe potential therapy for gout by restoring gut microbiota homeostasis and reducing uric acid levels. We hold the perspective that changing intestinal microbiota may become a vital method for effectively preventing or treating gout.
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肠道微生物群在痛风中发挥着重要作用
随着社会经济的发展,痛风的发病率越来越高,这与人们日益丰富的饮食结构密切相关。长期食用高嘌呤、高脂肪、高糖、低纤维的饮食会影响尿酸代谢,从而进一步加重痛风。尿酸的肾脏代谢机制已被深入研究。为了找到治疗痛风的新方法,近来对尿酸的肠道排泄、代谢和吸收机制的研究越来越多。最重要的研究是肠道微生物群与痛风风险之间的关系。肠道微生物群代表居住在宿主胃肠道中的细菌。肠道微生物群的组成与防止病原体定植和疾病发生有关。本综述重点探讨肠道微生物群如何通过尿酸影响痛风,并讨论可能参与痛风发生和发展的细菌类型。我们还介绍了通过恢复肠道微生物群平衡和降低尿酸水平来治疗痛风的潜在方法。我们认为,改变肠道微生物群可能成为有效预防或治疗痛风的重要方法。
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来源期刊
Journal of medical microbiology
Journal of medical microbiology 医学-微生物学
CiteScore
5.50
自引率
3.30%
发文量
143
审稿时长
4.5 months
期刊介绍: Journal of Medical Microbiology provides comprehensive coverage of medical, dental and veterinary microbiology, and infectious diseases. We welcome everything from laboratory research to clinical trials, including bacteriology, virology, mycology and parasitology. We publish articles under the following subject categories: Antimicrobial resistance; Clinical microbiology; Disease, diagnosis and diagnostics; Medical mycology; Molecular and microbial epidemiology; Microbiome and microbial ecology in health; One Health; Pathogenesis, virulence and host response; Prevention, therapy and therapeutics
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