Dietary restriction extends lifespan across different temperatures in the fly

IF 4.6 1区环境科学与生态学 Q1 ECOLOGY Functional Ecology Pub Date : 2024-04-19 DOI:10.1111/1365-2435.14563

Eleanor J. Phillips, Mirre J. P. Simons

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限制饮食可延长苍蝇在不同温度下的寿命

在一系列类群中，饮食限制（DR）一直被证明可以延长寿命。然而，最近有报道称，在特定温度下，即在较低温度下，DR 并不能延长苍蝇（黑腹果蝇）的寿命。与对其他似乎质疑 DR 普遍性的研究结果的解释类似，这一发现被解释为表明 DR 延长寿命是良性实验室条件的产物。我们重新检验了这一假说，现在我们使用的菌株在 25°C（之前的三次实验）下显示出强大的寿命延长能力，并使用了 18°C 和 21°C 两种温度下的五种饮食。我们发现 DR 的长寿反应非常稳健，无论温度如何都能延长寿命。我们测量了繁殖力，作为 DR 表型的阳性对照，结果发现，正如预测的那样，DR 会减少产卵量。我们认为，实验设置、使用的基因品系和饮食-寿命反应标准的差异是造成这种差异的原因。此外，像我们在这里所做的那样，从显示 DR 延长寿命的品系和条件开始，然后改变环境和/或基因型，有望对 DR 调节因素进行更可靠的测试。总之，重要的是不要轻易过度解读质疑DR表型的结果，因为在样本量大大增加和饮食范围扩大的情况下，我们无法复制之前的工作。在期刊博客上免费阅读本文的通俗摘要。

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来源期刊

Functional Ecology 环境科学-生态学

CiteScore

9.00

自引率

1.90%

发文量

243

审稿时长

4 months

期刊介绍： Functional Ecology publishes high-impact papers that enable a mechanistic understanding of ecological pattern and process from the organismic to the ecosystem scale. Because of the multifaceted nature of this challenge, papers can be based on a wide range of approaches. Thus, manuscripts may vary from physiological, genetics, life-history, and behavioural perspectives for organismal studies to community and biogeochemical studies when the goal is to understand ecosystem and larger scale ecological phenomena. We believe that the diverse nature of our journal is a strength, not a weakness, and we are open-minded about the variety of data, research approaches and types of studies that we publish. Certain key areas will continue to be emphasized: studies that integrate genomics with ecology, studies that examine how key aspects of physiology (e.g., stress) impact the ecology of animals and plants, or vice versa, and how evolution shapes interactions among function and ecological traits. Ecology has increasingly moved towards the realization that organismal traits and activities are vital for understanding community dynamics and ecosystem processes, particularly in response to the rapid global changes occurring in earth’s environment, and Functional Ecology aims to publish such integrative papers.