The Hidden Enemy Within: Uncovering the Secrets of HIV Tissues Reservoirs and Current mRNA Vaccine Development

IF 0.8 4区 医学 Q4 IMMUNOLOGY Current HIV Research Pub Date : 2024-04-19 DOI:10.2174/011570162x301593240409072840
Satyendra Prakash, Mayank Kumar
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Abstract

:: Human Immunodeficiency Viruses (HIV) continue to pose a significant global health threat despite the availability of antiretroviral therapy (ART). As a retrovirus, HIV persists as a stable, integrated, and replication-competent provirus within a diverse array of long-lived cells for many years, often termed “latent reservoirs” in individuals. Thus, this review aims to furnish a comprehensive overview of diverse tissue reservoirs where HIV persists, elucidating their pathogenesis and advancement in their strategies for clinical management. Understanding the mechanisms underlying HIV persistence within tissue reservoirs is of significant interest in developing effective ART for suppressing the virus in the blood. In addition, we also discussed the ongoing mRNA HIV vaccine that has shown promising results in clinical trials to elicit broadly neutralizing antibodies and effective T-cell responses against HIV.
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隐藏在体内的敌人揭开艾滋病毒组织储库的秘密与当前 mRNA 疫苗的开发
::尽管有了抗逆转录病毒疗法(ART),人类免疫缺陷病毒(HIV)仍然对全球健康构成重大威胁。作为一种逆转录病毒,HIV 以稳定、整合和具有复制能力的前病毒形式存在于各种长寿命细胞中多年,这些细胞通常被称为个体的 "潜伏库"。因此,本综述旨在全面概述艾滋病毒持续存在的各种组织储库,阐明其发病机制,并推进临床管理策略。了解艾滋病病毒在组织储库中持续存在的机制,对于开发有效的抗逆转录病毒疗法以抑制血液中的病毒具有重要意义。此外,我们还讨论了正在进行的 mRNA HIV 疫苗,该疫苗在临床试验中显示出了诱导广泛中和抗体和有效的 T 细胞抗 HIV 反应的良好效果。
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来源期刊
Current HIV Research
Current HIV Research 医学-病毒学
CiteScore
1.90
自引率
10.00%
发文量
81
审稿时长
6-12 weeks
期刊介绍: Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.
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