Development of the Binocular Circuit

IF 12.1 1区 医学 Q1 NEUROSCIENCES Annual review of neuroscience Pub Date : 2024-04-18 DOI:10.1146/annurev-neuro-111020-093230
Eloísa Herrera, Alain Chédotal, Carol Mason
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Abstract

Seeing in three dimensions is a major property of the visual system in mammals. The circuit underlying this property begins in the retina, from which retinal ganglion cells (RGCs) extend to the same or opposite side of the brain. RGC axons decussate to form the optic chiasm, then grow to targets in the thalamus and midbrain, where they synapse with neurons that project to the visual cortex. Here we review the cellular and molecular mechanisms of RGC axonal growth cone guidance across or away from the midline via receptors to cues in the midline environment. We present new views on the specification of ipsi- and contralateral RGC subpopulations and factors implementing their organization in the optic tract and termination in subregions of their targets. Lastly, we describe the functional and behavioral aspects of binocular vision, focusing on the mouse, and discuss recent discoveries on the evolution of the binocular circuit.
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双目电路的发展
立体视觉是哺乳动物视觉系统的一个主要特性。这一特性的基础回路始于视网膜,视网膜神经节细胞(RGC)从视网膜延伸到大脑的同侧或对侧。RGC 轴突决裂形成视交叉,然后向丘脑和中脑的目标生长,并在那里与投射到视觉皮层的神经元发生突触。在这里,我们回顾了 RGC 轴突生长锥通过中线环境中的线索受体跨越或远离中线的细胞和分子机制。我们就同侧和对侧RGC亚群的规格化及其在视束中的组织和在目标亚区域中的终止因素提出了新的观点。最后,我们以小鼠为重点,描述了双目视觉的功能和行为方面,并讨论了双目回路进化的最新发现。
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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