Ultrasensitive electrochemical (bio)sensors for therapeutic drug monitoring

IF 7.9 2区化学 Q1 CHEMISTRY, PHYSICAL Current Opinion in Electrochemistry Pub Date : 2024-04-01 DOI:10.1016/j.coelec.2024.101501

M. David , M. Florescu

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Abstract

Ultrasensitive detection is important for the individualized management of medical therapy, playing a key role for the improvement of life expectancy and quality of life. Implementing personalized medicine represents a complex challenge since it requires the development of new, simple, versatile, and sustainable technologies that offer real-time, accurate, and reliable outputs. With increasing chronic conditions and cancers, as well as excessive use and abuse of medication, there is a strong need for continuous monitoring of therapeutic drugs to prevent toxicity levels in cases of overdose or inefficiency in cases of underdose.

However, to date, only a few easy-to-use monitoring systems are available for trace analysis of therapeutic drugs to help physicians and patients with therapeutic drug monitoring. Here, we critically evaluate recent advances, highlighting the position of electrochemical (bio)sensors on the roadmap towards ultrasensitive detection for personalized therapy.

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用于治疗药物监测的超灵敏电化学（生物）传感器

超灵敏检测对于个性化医疗管理非常重要，在提高预期寿命和生活质量方面发挥着关键作用。实施个性化医疗是一项复杂的挑战，因为它需要开发新的、简单的、多功能的和可持续的技术，以提供实时、准确和可靠的结果。随着慢性病和癌症的增加，以及药物的过度使用和滥用，亟需对治疗药物进行持续监测，以防止用药过量时产生毒性或用药不足时产生低效。

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来源期刊

Current Opinion in Electrochemistry Chemistry-Analytical Chemistry

CiteScore

14.00

自引率

5.90%

发文量

272

审稿时长

73 days

期刊介绍： The development of the Current Opinion journals stemmed from the acknowledgment of the growing challenge for specialists to stay abreast of the expanding volume of information within their field. In Current Opinion in Electrochemistry, they help the reader by providing in a systematic manner: 1.The views of experts on current advances in electrochemistry in a clear and readable form. 2.Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. In the realm of electrochemistry, the subject is divided into 12 themed sections, with each section undergoing an annual review cycle: • Bioelectrochemistry • Electrocatalysis • Electrochemical Materials and Engineering • Energy Storage: Batteries and Supercapacitors • Energy Transformation • Environmental Electrochemistry • Fundamental & Theoretical Electrochemistry • Innovative Methods in Electrochemistry • Organic & Molecular Electrochemistry • Physical & Nano-Electrochemistry • Sensors & Bio-sensors •