Nanomedicine-based disulfiram and metal ion co-delivery strategies for cancer treatment

IF 5.2 2区 医学 Q1 PHARMACOLOGY & PHARMACY International Journal of Pharmaceutics: X Pub Date : 2024-04-18 DOI:10.1016/j.ijpx.2024.100248
Xinyue Shen , Huixiang Sheng , Ying Zhang , Xuan Dong , Longfa Kou , Qing Yao , Xinyu Zhao
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Abstract

Disulfiram (DSF) is a second-line drug for the clinical treatment of alcoholism and has long been proven to be safe for use in clinical practice. In recent years, researchers have discovered the cancer-killing activity of DSF, which is highly dependent on the presence of metal ions, particularly copper ions. Additionally, free DSF is highly unstable and easily degraded within few minutes in blood circulation. Therefore, an ideal DSF formulation should facilitate the co-delivery of metal ions and safeguard the DSF throughout its biological journey before reaching the targeted site. Extensive research have proved that nanotechnology based formulations can effectively realize this goal by strategic encapsulation therapeutic agents within nanoparticle. To be more specific, this is accomplished through precise delivery, coordinated release of metal ions at the tumor site, thereby amplifying its cytotoxic potential. Beyond traditional co-loading techniques, innovative approaches such as DSF-metal complex and metal nanomaterials, have also demonstrated promising results at the animal model stage. This review aims to elucidate the anticancer mechanism associated with DSF and its reliance on metal ions, as well as to provide a comprehensive overview of recent advances in the arena of nanomedicine based co-delivery strategies for DSF and metal ion in the context of cancer therapy.

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基于纳米药物的双硫仑和金属离子联合给药癌症治疗策略
双硫仑(DSF)是临床治疗酒精中毒的二线药物,在临床实践中的应用早已被证明是安全的。近年来,研究人员发现,DSF 的杀癌活性高度依赖于金属离子,尤其是铜离子的存在。此外,游离的 DSF 极不稳定,在血液循环中几分钟内就容易降解。因此,理想的 DSF 配方应有助于金属离子的共同传递,并在到达目标部位之前的整个生物过程中保护 DSF。广泛的研究证明,基于纳米技术的配方可以通过将治疗剂战略性地封装在纳米粒子中来有效实现这一目标。更具体地说,这是通过在肿瘤部位精确输送、协调释放金属离子,从而放大其细胞毒性潜力来实现的。除了传统的共负载技术,DSF-金属复合物和金属纳米材料等创新方法也在动物模型阶段取得了可喜的成果。本综述旨在阐明与 DSF 相关的抗癌机制及其对金属离子的依赖,并全面概述基于纳米药物的 DSF 和金属离子联合给药策略在癌症治疗领域的最新进展。
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来源期刊
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
6.60
自引率
0.00%
发文量
32
审稿时长
24 days
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