{"title":"Optimization strategies for CO2 biological fixation","authors":"Xiutao Liu , Linqing Li , Guang Zhao , Peng Xiong","doi":"10.1016/j.biotechadv.2024.108364","DOIUrl":null,"url":null,"abstract":"<div><p>Global sustainable development faces a significant challenge in effectively utilizing CO<sub>2</sub>. Meanwhile, CO<sub>2</sub> biological fixation offers a promising solution. CO<sub>2</sub> has the highest oxidation state (+4 valence state), whereas typical multi‑carbon chemicals have lower valence states. The Gibbs free energy (Δ<em>G</em>) changes of CO<sub>2</sub> reductive reactions are generally positive and this renders it necessary to input different forms of energy. Although biological carbon fixation processes are friendly to operate, the thermodynamic obstacles must be overcome. To make this reaction occur favorably and efficiently, diverse strategies to enhance CO<sub>2</sub> biological fixation efficiency have been proposed by numerous researchers. This article reviews recent advances in optimizing CO<sub>2</sub> biological fixation and intends to provide new insights into achieving efficient biological utilization of CO<sub>2</sub>. It first outlines the thermodynamic characteristics of diverse carbon fixation reactions and proposes optimization directions for CO<sub>2</sub> biological fixation. A comprehensive overview of the catalytic mechanisms, optimization strategies, and challenges encountered by common carbon-fixing enzymes is then provided. Subsequently, potential routes for improving the efficiency of biological carbon fixation are discussed, including the ATP supply, reducing power supply, energy supply, reactor design, and carbon enrichment system modules. In addition, effective artificial carbon fixation pathways were summarized and analyzed. Finally, prospects are made for the research direction of continuously improving the efficiency of biological carbon fixation.</p></div>","PeriodicalId":8946,"journal":{"name":"Biotechnology advances","volume":null,"pages":null},"PeriodicalIF":12.1000,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biotechnology advances","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0734975024000582","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Global sustainable development faces a significant challenge in effectively utilizing CO2. Meanwhile, CO2 biological fixation offers a promising solution. CO2 has the highest oxidation state (+4 valence state), whereas typical multi‑carbon chemicals have lower valence states. The Gibbs free energy (ΔG) changes of CO2 reductive reactions are generally positive and this renders it necessary to input different forms of energy. Although biological carbon fixation processes are friendly to operate, the thermodynamic obstacles must be overcome. To make this reaction occur favorably and efficiently, diverse strategies to enhance CO2 biological fixation efficiency have been proposed by numerous researchers. This article reviews recent advances in optimizing CO2 biological fixation and intends to provide new insights into achieving efficient biological utilization of CO2. It first outlines the thermodynamic characteristics of diverse carbon fixation reactions and proposes optimization directions for CO2 biological fixation. A comprehensive overview of the catalytic mechanisms, optimization strategies, and challenges encountered by common carbon-fixing enzymes is then provided. Subsequently, potential routes for improving the efficiency of biological carbon fixation are discussed, including the ATP supply, reducing power supply, energy supply, reactor design, and carbon enrichment system modules. In addition, effective artificial carbon fixation pathways were summarized and analyzed. Finally, prospects are made for the research direction of continuously improving the efficiency of biological carbon fixation.
全球可持续发展面临着有效利用二氧化碳的巨大挑战。与此同时,二氧化碳生物固定技术提供了一个前景广阔的解决方案。二氧化碳的氧化态最高(+4 价态),而典型的多碳化学品的价态较低。二氧化碳还原反应的吉布斯自由能(ΔG)变化一般为正值,因此需要输入不同形式的能量。虽然生物固碳过程操作简便,但必须克服热力学障碍。为了使这一反应顺利、高效地进行,许多研究人员提出了提高二氧化碳生物固定效率的各种策略。本文回顾了优化二氧化碳生物固定的最新进展,旨在为实现二氧化碳的高效生物利用提供新的见解。文章首先概述了各种固碳反应的热力学特征,并提出了二氧化碳生物固定的优化方向。然后全面概述了常见固碳酶的催化机理、优化策略和遇到的挑战。随后,讨论了提高生物固碳效率的潜在途径,包括 ATP 供应、还原电源供应、能源供应、反应器设计和碳富集系统模块。此外,还总结分析了有效的人工固碳途径。最后,对不断提高生物固碳效率的研究方向进行了展望。
期刊介绍:
Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.