Acetyl-CoA-independent malonyl-CoA biosynthesis

IF 42.8 1区化学 Q1 CHEMISTRY, PHYSICAL Nature Catalysis Pub Date : 2024-04-26 DOI:10.1038/s41929-024-01139-y

Dongsoo Yang

引用次数: 0

Abstract

Malonyl-CoA is one of the fundamental building blocks for the synthesis of industrially or pharmaceutically important chemicals, but its biosynthesis via the innate acetyl-CoA carboxylation pathway remains slow and inefficient. Now, an artificial non-carboxylative malonyl-CoA biosynthetic pathway has been developed, significantly enhancing malonyl-CoA supply by boosting carbon and energy efficiency while sidestepping the inhibitions by host cell regulations.

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乙酰-CoA 独立丙二酰-CoA 生物合成

丙二酰-CoA 是合成重要工业或医药化学品的基本构件之一，但通过乙酰-CoA 羧化途径进行的生物合成仍然缓慢而低效。现在，一种人工非羧化丙二酰-CoA 生物合成途径已被开发出来，它通过提高碳和能量效率来显著增强丙二酰-CoA 的供应，同时避开了宿主细胞调控的抑制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Catalysis Chemical Engineering-Bioengineering

CiteScore

52.10

自引率

1.10%

发文量

140

期刊介绍： Nature Catalysis serves as a platform for researchers across chemistry and related fields, focusing on homogeneous catalysis, heterogeneous catalysis, and biocatalysts, encompassing both fundamental and applied studies. With a particular emphasis on advancing sustainable industries and processes, the journal provides comprehensive coverage of catalysis research, appealing to scientists, engineers, and researchers in academia and industry. Maintaining the high standards of the Nature brand, Nature Catalysis boasts a dedicated team of professional editors, rigorous peer-review processes, and swift publication times, ensuring editorial independence and quality. The journal publishes work spanning heterogeneous catalysis, homogeneous catalysis, and biocatalysis, covering areas such as catalytic synthesis, mechanisms, characterization, computational studies, nanoparticle catalysis, electrocatalysis, photocatalysis, environmental catalysis, asymmetric catalysis, and various forms of organocatalysis.