Still Far to Go With Characterisation of Molecular and Genetic Features of Diffuse Large B-Cell Lymphoma in People Living With HIV: A Scoping Review

IF 4.7 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-04-19 DOI:10.3389/or.2024.1375291

Maudy C P Manyau, Blessing Zambuko, Moses Chatambudza, Danai T Zhou, Justen Manasa

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Abstract

Diffuse large B-cell lymphoma (DLBCL) accounts for half of non-Hodgkin lymphoma cases in people living with human immunodeficiency syndrome (PLWH). The interplay of viremia, immune dysregulation and co-infection with oncogenic viruses play a role in pathogenesis of DLBCL in PLWH (HIV-DLBCL). This scoping review aimed to describe the molecular landscape of HIV-DLBCL, investigate the impact of biomarker on clinical outcomes and describe technologies used to characterise HIV-DLBCL. Thirty-two papers published between 2001 and 2023 were included in this review. Samples of HIV-DLBCL were relatively small (16–110). Cohort effects influenced frequencies of molecular characteristics hence their impact on survival was not clear. Molecular features were distinct from HIV-unrelated DLBCL. The most frequently assessed characteristic was cell of origin (81.3% of studies). Somatic mutations were the least researched (6.3% of studies). Overall, biomarker identification in HIV-DLBCL requires broader richer data from larger or pooled samples using more powerful techniques such as next-generation sequencing.

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艾滋病病毒感染者弥漫性大 B 细胞淋巴瘤的分子和遗传特征描述仍任重道远：范围界定综述

弥漫大 B 细胞淋巴瘤（DLBCL）占人类免疫缺陷综合征（PLWH）患者非霍奇金淋巴瘤病例的一半。病毒血症、免疫调节失调和致癌病毒的合并感染在人类免疫缺陷综合征（PLWH）患者弥漫性大B细胞淋巴瘤（DLBCL）的发病机制中起着相互作用。本范围综述旨在描述 HIV-DLBCL 的分子状况，研究生物标志物对临床结果的影响，并描述用于描述 HIV-DLBCL 特征的技术。本次综述纳入了 32 篇发表于 2001 年至 2023 年的论文。HIV-DLBCL的样本相对较小（16-110）。队列效应影响了分子特征的频率，因此其对存活率的影响并不明确。分子特征有别于与艾滋病毒无关的DLBCL。最常评估的特征是起源细胞（81.3%的研究）。体细胞突变的研究最少（6.3% 的研究）。总的来说，HIV-DLBCL的生物标志物鉴定需要使用更强大的技术（如新一代测序），从更大或更集中的样本中获得更广泛、更丰富的数据。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico

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