The use of mesenchymal stem cells in tendon regeneration in rats.

Concilium Pub Date : 2024-04-13 DOI:10.53660/clm-3208-24g05
A. F. Soares, Moisés Bonifácio Alves Ferreira-Filho, Maria Vitória da Silva Xavier, Victória Alferis Lima, Marcelo Weinstein Teixeira, Mariza Brandão Palma
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Abstract

Mesenchymal stem cells are of great interest due to their regenerative potential and capacity to transdifferentiate into various cell lineages. The present study executed a narrative review of the literature on the influence of mesenchymal stem cells on the regeneration of tendon injuries. To acomplish this, a search was carried out in the Pubmed and Scielo databases using descriptors such as: Mesenchymal stem cell regeneration and application tendon rat; Embryonic Stem Cell-Derived Mesenchymal Stem Cells for Tendon Tissue rat. Only research articles carried out on rats between 2011 and 2023 were included. 935 articles were found in the Pubmed database, and 43 articles were included based on the criteria of categorization, analysis of titles and abstracts. The articles showed benefits in relation to the use of stem cells in rat tendon injuries, but some studies showed that this repair was not 100% guaranteed to the state of the tendon originally, but associated with growth factors obtained a better induction of tenogenesis.
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在大鼠肌腱再生中使用间充质干细胞。
间充质干细胞因其再生潜力和转分化为各种细胞系的能力而备受关注。本研究对有关间充质干细胞对肌腱损伤再生影响的文献进行了叙述性综述。为此,我们在Pubmed和Scielo数据库中使用以下描述符进行了搜索:间充质干细胞再生和应用肌腱大鼠;胚胎干细胞衍生的间充质干细胞用于肌腱组织大鼠。仅收录了 2011 年至 2023 年期间对大鼠进行的研究文章。在 Pubmed 数据库中找到了 935 篇文章,根据分类、标题和摘要分析标准,纳入了 43 篇文章。这些文章显示了在大鼠肌腱损伤中使用干细胞的益处,但一些研究表明,这种修复并不能100%保证肌腱的原始状态,但与生长因子相关的干细胞能更好地诱导肌腱生成。
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