Altered Haematological Parameters in Gasoline Station Workers due to Benzene Exposure

Safety Pub Date : 2024-04-12 DOI:10.3390/safety10020038
S. Chaiklieng, Umakorn Tongsantia, P. Suggaravetsiri, Herman Autrup
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Abstract

Benzene is harmful to human health and early detection of haematological alterations is important in preventing adverse health effects. This study aimed to investigate the biomarkers of benzene exposure and its effects due to haematological alterations. Gasoline station workers with potential risks according to the biomatrix concerning benzene exposure underwent blood and urine evaluation for the biological monitoring of urinary trans, trans-muconic acid (tt-MA), and haematological and biochemical parameter evaluation. The results were analysed for correlations between biological and haematological effects. The tt-MA biomarker was detected in some workers and approximately 50% of workers had a blood profile that showed abnormal parameters with respect to the haemoglobin (Hb), haematocrit (Hct) and white blood cell parameters, which were outside the normal range. A significant correlation was observed between the tt-MA biomarker’s level and the levels of the haematological and biochemical parameters, which were Hb, Hct, eosinophil, neutrophil, SGOT and blood creatinine. The level of urinary tt-MA as a marker of benzene exposure correlated with haematological and biochemical changes in the blood, suggesting that the gasoline station workers were affected by benzene exposure. Moreover, the current study suggests that early detection of haematological abnormalities may be possible by analysing biomarkers of their effects through regular health surveillance of workers.
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加油站工人因接触苯而导致的血液参数变化
苯对人体健康有害,及早发现血液学改变对预防不良健康影响非常重要。本研究旨在调查苯暴露的生物标志物及其对血液学改变的影响。根据有关苯暴露的生物矩阵,对具有潜在风险的加油站工人进行了血液和尿液评估,以对尿液中的反式、反式粘液酸(tt-MA)进行生物监测,并对血液和生化参数进行评估。对结果进行了分析,以确定生物效应和血液效应之间的相关性。在一些工人体内检测到了tt-MA 生物标志物,约 50%的工人的血型显示血红蛋白(Hb)、血细胞比容(Hct)和白细胞参数异常,超出了正常范围。tt-MA生物标志物的水平与血红蛋白、血细胞比容(Hct)、嗜酸性粒细胞、中性粒细胞、谷丙转氨酶(SGOT)和血肌酐等血液和生化指标的水平之间存在明显的相关性。作为苯暴露标志物的尿tt-MA水平与血液中的血液学和生化指标变化相关,这表明加油站工人受到了苯暴露的影响。此外,本研究还表明,通过对工人进行定期健康监测,分析其影响的生物标志物,可以及早发现血液异常。
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