A safer method for disinfection of Bacillus Calmette-Guerin-containing urine: a prospective, randomized study.

Urologia Internationalis Pub Date : 2024-04-12 DOI:10.1159/000538758

Tomohiro Kameda, Yoshimasa Kondo, Yasuko Fukataki, Shiro Hinotsu, Tetsuya Fujimura, Tatsuya Takayama

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Abstract

INTRODUCTION To examine whether disinfection of Bacillus Calmette-Guerin -containing urine with etaprocohol® (Ethanol 76.9-81.4 vol % and isopropanol as an additive) is safer than disinfection with sodium hypochlorite. METHOD In prospective research, safety, and efficacy was analyzed in five patients in the etaprocohol® disinfection group and five patients in the sodium hypochlorite disinfection group. The primary endpoint was the temperature change after disinfection and the secondary endpoint was the unpleasantness of the odor caused by disinfection. Additionally, concentration of gas produced was also examined. Sensory tests were taken from staff who performed urine disinfection and the odor generated by disinfection was evaluated. As a safety protocol, post-BCG-treated urine is cultured to verify the negative for Mycobacteria. RESULTS Mycobacteria was disinfected in all cases. The temperature rise following disinfection was significantly higher in the sodium hypochlorite group. The sensory test outcomes were significantly worse in the group disinfected with sodium hypochlorite. The concentration of gas generated immediately after disinfection in both groups reached the maximum value and declined quickly. CONCLUSIONS Disinfection of Bacillus Calmette-Guerin -containing urine with etaprocohol® was safer than disinfection with sodium hypochlorite, and an equivalent disinfection effect was achieved.

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一种更安全的含卡介苗杆菌尿液消毒方法：一项前瞻性随机研究。

方法在前瞻性研究中，对依他普醇®消毒组和次氯酸钠消毒组的五名患者进行了安全性和有效性分析。主要终点是消毒后的温度变化，次要终点是消毒后产生的难闻气味。此外，还对产生的气体浓度进行了检测。对进行尿液消毒的工作人员进行了感官测试，并对消毒产生的气味进行了评估。作为一项安全措施，对经 BCG 处理后的尿液进行培养，以确认分枝杆菌呈阴性。次氯酸钠组消毒后的温升明显更高。次氯酸钠消毒组的感官测试结果明显较差。两组消毒后立即产生的气体浓度均达到最大值，并迅速下降。

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Urologia Internationalis

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