CancerMHL: the database of integrating key DNA methylation, histone modifications and lncRNAs in cancer

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-04-12 DOI:10.1093/database/baae029

Pengyu Du, Yingli Chen, Qianzhong Li, Zhimin Gai, Hui Bai, Luqiang Zhang, Yuxian Liu, Yanni Cao, Yuanyuan Zhai, Wen Jin

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Abstract

Abstract The discovery of key epigenetic modifications in cancer is of great significance for the study of disease biomarkers. Through the mining of epigenetic modification data relevant to cancer, some researches on epigenetic modifications are accumulating. In order to make it easier to integrate the effects of key epigenetic modifications on the related cancers, we established CancerMHL (http://www.positionprediction.cn/), which provide key DNA methylation, histone modifications and lncRNAs as well as the effect of these key epigenetic modifications on gene expression in several cancers. To facilitate data retrieval, CancerMHL offers flexible query options and filters, allowing users to access specific key epigenetic modifications according to their own needs. In addition, based on the epigenetic modification data, three online prediction tools had been offered in CancerMHL for users. CancerMHL will be a useful resource platform for further exploring novel and potential biomarkers and therapeutic targets in cancer. Database URL: http://www.positionprediction.cn/

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CancerMHL：整合癌症中关键 DNA 甲基化、组蛋白修饰和 lncRNA 的数据库

摘要癌症中关键表观遗传修饰的发现对于疾病生物标志物的研究具有重要意义。通过挖掘与癌症相关的表观遗传修饰数据，有关表观遗传修饰的研究正在不断积累。为了更方便地整合关键表观遗传修饰对相关癌症的影响，我们建立了CancerMHL（http://www.positionprediction.cn/），它提供了几种癌症的关键DNA甲基化、组蛋白修饰和lncRNA，以及这些关键表观遗传修饰对基因表达的影响。为了方便数据检索，CancerMHL 提供了灵活的查询选项和过滤器，用户可以根据自己的需要访问特定的关键表观遗传修饰。此外，基于表观遗传修饰数据，CancerMHL 还为用户提供了三种在线预测工具。CancerMHL将成为一个有用的资源平台，用于进一步探索癌症中新的、潜在的生物标志物和治疗靶点。数据库网址： http://www.positionprediction.cn/

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