More than the SRY: The Non-Coding Landscape of the Y Chromosome and Its Importance in Human Disease.

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Non-Coding RNA Pub Date : 2024-04-10 DOI:10.3390/ncrna10020021

Emily S. Westemeier-Rice, Michael T. Winters, Travis W. Rawson, Ivan Martinez

引用次数: 0

Abstract

Historically, the Y chromosome has presented challenges to classical methodology and philosophy of understanding the differences between males and females. A genetic unsolved puzzle, the Y chromosome was the last chromosome to be fully sequenced. With the advent of the Human Genome Project came a realization that the human genome is more than just genes encoding proteins, and an entire universe of RNA was discovered. This dark matter of biology and the black box surrounding the Y chromosome have collided over the last few years, as increasing numbers of non-coding RNAs have been identified across the length of the Y chromosome, many of which have played significant roles in disease. In this review, we will uncover what is known about the connections between the Y chromosome and the non-coding RNA universe that originates from it, particularly as it relates to long non-coding RNAs, microRNAs and circular RNAs.

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超越 SRY：Y 染色体的非编码结构及其在人类疾病中的重要性》（More than the SRY: The Non-Coding Landscape of the Y Chromosome and Its Importance in Human Disease）。

从历史上看，Y 染色体对理解男女差异的经典方法论和哲学提出了挑战。作为一个未解的基因谜题，Y 染色体是最后一个被完全测序的染色体。随着人类基因组计划的出现，人们意识到人类基因组不仅仅是编码蛋白质的基因，还发现了整个 RNA 宇宙。在过去几年中，这一生物学暗物质与围绕 Y 染色体的黑匣子发生了碰撞，因为在 Y 染色体的整个长度上发现了越来越多的非编码 RNA，其中许多在疾病中发挥了重要作用。在这篇综述中，我们将揭示 Y 染色体与源于 Y 染色体的非编码 RNA 之间的关系，尤其是与长非编码 RNA、microRNA 和环状 RNA 的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

6.70

自引率

4.70%

发文量

审稿时长

10 weeks

期刊介绍： Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.

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