Alzheimer’s disease, biomarkers and the role of the inflammatory profile in the cerebrospinal fluid

Concilium Pub Date : 2024-04-03 DOI:10.53660/clm-3179-24f34
Leidson Rodrigo Teixeira Ribeiro, Glesley Vito Lima Lemos, Luan Cezar Côrtes Silva, Marianna Santana Santos, Conceição Neves Ferraz, Aníbal de Freitas Santos Júnior, Paulo Roberto Santana de Melo, Bruno Antônio Veloso Cerqueira
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Abstract

Introduction: Amyloid plaques and neurofibrillary tangles are associated with neuronal injury in Alzheimer's disease (AD). Objective: To investigate the relationship between biomarkers of neurodegeneration and the inflammatory profile in the cerebrospinal fluid (CSF) of patients with AD and mild cognitive impairment (MCI). Methods: A cross-sectional study including data on biochemical markers and clinical characteristics related to CSF biomarkers (p-tau, t-tau, and Aβ1-42) of 51 patients with MCI or AD was performed. Results:  A positive correlation between lactate dehydrogenase (LDH) and both p-tau (r=0.548; p<0.001) and t-tau (r=0.757; p<0.001), a negative correlation between lactate and p-tau (r=0.399; p<0.005), and a positive correlation between aspartate aminotransferase and p-tau (r=0.489; p<0.001) were found. Discussion: The positive correlation between LDH and tau protein points to a role for oxidative stress in AD. The negative correlation between lactate and p-tau suggests a detrimental effect of tau protein on cell metabolism. Conclusions: Inflammatory biomarkers might aid in AD workup. Technical simplicity and their potential association with tau protein warrant further research into LDH and lactate in AD.
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阿尔茨海默病、生物标志物和脑脊液中炎症特征的作用
简介淀粉样蛋白斑块和神经纤维缠结与阿尔茨海默病(AD)的神经元损伤有关。研究目的研究神经退行性变的生物标志物与 AD 和轻度认知障碍(MCI)患者脑脊液(CSF)中炎症特征之间的关系。研究方法对 51 名 MCI 或 AD 患者进行横断面研究,包括与 CSF 生物标志物(p-tau、t-tau 和 Aβ1-42)相关的生化标志物数据和临床特征。结果显示 发现乳酸脱氢酶(LDH)与p-tau(r=0.548;p<0.001)和t-tau(r=0.757;p<0.001)呈正相关,乳酸盐与p-tau呈负相关(r=0.399;p<0.005),天冬氨酸氨基转移酶与p-tau呈正相关(r=0.489;p<0.001)。讨论LDH与tau蛋白之间的正相关性表明氧化应激在AD中的作用。乳酸和 p-tau 之间的负相关表明 tau 蛋白对细胞代谢有不利影响。结论炎症生物标志物可能有助于AD的诊断。技术上的简便性及其与 tau 蛋白的潜在关联使得我们有必要进一步研究 AD 中的 LDH 和乳酸盐。
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