Characteristics and biological responses of selective laser melted Ti6Al4V modified by micro-arc oxidation

IF 3.4 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of Dental Sciences Pub Date : 2024-07-01 DOI:10.1016/j.jds.2024.04.007
An-Nghia Nguyen , Kuan-Chen Kung , Ken-Chung Chen , Cheng-Wei Hsu , Chih-Ling Huang , Tzer-Min Lee
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Abstract

Background/purpose

Additive manufacturing (AM) technology, such as selective laser melting (SLM), has been used to fabricate medical devices of Ti-6wt.% Al-4wt.%V (Ti6Al4V) alloys in dentistry. Strontium (Sr) has been shown to have the potential to treat osteoporosis. The aim of this study was to investigate the physicochemical and biological properties of strontium-containing coatings on selective laser melted Ti6Al4V (SLM-Ti6Al4V) substrate.

Materials and methods

The disk of Ti6Al4V was prepared by SLM method. The strontium-containing coatings were prepared by micro-arc oxidation (MAO) in aqueous electrolytes. The surface topography, chemical composition, and phase of strontium-containing MAO (SrMAO) coatings were performed by scanning electron microscope (SEM), energy dispersive X-ray spectrometer (EDS), and thin film X-ray diffraction (TF-XRD), respectively. The apatite-forming ability of the MAO coatings was conducted in simulating body fluid (SBF), and the cell proliferation was determined by methylthiazoletetrazolium (MTT) assay.

Results

The microstructure of SLM-Ti6Al4V displays acicular α-phase organization. The TF-XRD results indicated that the phase of SrMAO coating was anatase, rutile, and titanium. The calcium, phosphorus, and strontium were detected in the coatings by EDS. Using the SEM, the surface morphology of SrMAO coatings exhibited a uniform 3D porous structure. The SrMAO coatings could induce a bone-like apatite layer after immersion in SBF, and presented significantly higher cell proliferation than untreated specimens in in-vitro experiments.

Conclusion

All findings in this study indicate that SrMAO coatings formed on SLM-Ti6Al4V surfaces exhibit a benefit on biological responses and thereby are suitable for biomedical applications.

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经微弧氧化改性的选择性激光熔融 Ti6Al4V 的特性和生物反应
背景/目的选择性激光熔化(SLM)等快速成型制造(AM)技术已被用于制造牙科中的钛-6wt.%铝-4wt.%钒(Ti6Al4V)合金医疗设备。锶(Sr)已被证明具有治疗骨质疏松症的潜力。本研究旨在研究选择性激光熔融 Ti6Al4V(SLM-Ti6Al4V)基底上含锶涂层的物理化学和生物学特性。含锶涂层是在水性电解质中通过微弧氧化(MAO)制备的。扫描电子显微镜(SEM)、能量色散 X 射线光谱仪(EDS)和薄膜 X 射线衍射仪(TF-XRD)分别对含锶 MAO(SrMAO)涂层的表面形貌、化学成分和相进行了研究。结果SLM-Ti6Al4V 的微观结构显示出针状 α 相组织。TF-XRD 结果表明,SrMAO 涂层的相为锐钛矿相、金红石相和钛相。EDS 检测到了涂层中的钙、磷和锶。通过扫描电子显微镜,SrMAO 涂层的表面形态呈现出均匀的三维多孔结构。本研究的所有结果表明,在 SLM-Ti6Al4V 表面形成的 SrMAO 涂层有利于生物反应,因此适用于生物医学应用。
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来源期刊
Journal of Dental Sciences
Journal of Dental Sciences 医学-牙科与口腔外科
CiteScore
5.10
自引率
14.30%
发文量
348
审稿时长
6 days
期刊介绍: he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.
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