Yun-Feng Liu , Hui-Fang Du , Ya-Hui Zhang , Zhi-Qin Liu , Xiao-Qian Qi , Du-Qiang Luo , Fei Cao
{"title":"Chaeglobol A, an unusual octocyclic sterol with antifungal activity from the marine-derived fungus Chaetomium globosum HBU-45","authors":"Yun-Feng Liu , Hui-Fang Du , Ya-Hui Zhang , Zhi-Qin Liu , Xiao-Qian Qi , Du-Qiang Luo , Fei Cao","doi":"10.1016/j.cclet.2024.109858","DOIUrl":null,"url":null,"abstract":"<div><div>Chemical investigation of the marine-derived fungus <em>Chaetomium globosum</em> HBU-45 led to the discovery of chaeglobol A (<strong>1</strong>). Its structure was determined by spectroscopic analysis, computational electronic circular dichroism (ECD)/optical rotatory dispersion (ORD) methods, and X-ray crystallography. Compound <strong>1</strong> represents a new skeleton with an uncommon 6/6/6/5/6/5/6/5 octacyclic system, which is presumably biosynthesized <em>via</em> a [4 + 2] cycloaddition and an enzymatic cyclization. Chaeglobol A (<strong>1</strong>) exhibited inhibitory activity against <em>B. dothidea</em> by destroying cell membrane integrity and causing oxidative damage within the cells.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"36 3","pages":"Article 109858"},"PeriodicalIF":9.4000,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Chemical Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1001841724003772","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Chemical investigation of the marine-derived fungus Chaetomium globosum HBU-45 led to the discovery of chaeglobol A (1). Its structure was determined by spectroscopic analysis, computational electronic circular dichroism (ECD)/optical rotatory dispersion (ORD) methods, and X-ray crystallography. Compound 1 represents a new skeleton with an uncommon 6/6/6/5/6/5/6/5 octacyclic system, which is presumably biosynthesized via a [4 + 2] cycloaddition and an enzymatic cyclization. Chaeglobol A (1) exhibited inhibitory activity against B. dothidea by destroying cell membrane integrity and causing oxidative damage within the cells.
期刊介绍：
Chinese Chemical Letters (CCL) (ISSN 1001-8417) was founded in July 1990. The journal publishes preliminary accounts in the whole field of chemistry, including inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, polymer chemistry, applied chemistry, etc.Chinese Chemical Letters does not accept articles previously published or scheduled to be published. To verify originality, your article may be checked by the originality detection service CrossCheck.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
