{"title":"Ultra-sensitive electrochemical immunosensors for clinically important biomarker detection: Prospects, opportunities, and global trends","authors":"Anton Popov , Benediktas Brasiunas , Katazyna Blazevic , Asta Kausaite-Minkstimiene , Almira Ramanaviciene","doi":"10.1016/j.coelec.2024.101524","DOIUrl":null,"url":null,"abstract":"<div><p>This review delves into the many methods by which the specific affinity interaction between antigens and antibodies can be converted into a measurable signal. It provides a synoptic overview of the latest innovations in the realm of electrochemical immunosensor development, with a focus on the diverse technologies and strategies aimed at enhancing analytical signals and detecting ultra-low concentrations of biomarkers. The most important trends in developing multiplexed, non-invasive, or attachable immunosensors and Point-of-Care Testing platforms leveraging various nanomaterials are discussed. Furthermore, global trends in label-free and labelled electrochemical immunosensors are reviewed, taking into account the evolving requirements of patients.</p></div>","PeriodicalId":11028,"journal":{"name":"Current Opinion in Electrochemistry","volume":"46 ","pages":"Article 101524"},"PeriodicalIF":7.9000,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Electrochemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451910324000851","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
This review delves into the many methods by which the specific affinity interaction between antigens and antibodies can be converted into a measurable signal. It provides a synoptic overview of the latest innovations in the realm of electrochemical immunosensor development, with a focus on the diverse technologies and strategies aimed at enhancing analytical signals and detecting ultra-low concentrations of biomarkers. The most important trends in developing multiplexed, non-invasive, or attachable immunosensors and Point-of-Care Testing platforms leveraging various nanomaterials are discussed. Furthermore, global trends in label-free and labelled electrochemical immunosensors are reviewed, taking into account the evolving requirements of patients.
期刊介绍：
The development of the Current Opinion journals stemmed from the acknowledgment of the growing challenge for specialists to stay abreast of the expanding volume of information within their field. In Current Opinion in Electrochemistry, they help the reader by providing in a systematic manner:
1.The views of experts on current advances in electrochemistry in a clear and readable form.
2.Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.
In the realm of electrochemistry, the subject is divided into 12 themed sections, with each section undergoing an annual review cycle:
• Bioelectrochemistry • Electrocatalysis • Electrochemical Materials and Engineering • Energy Storage: Batteries and Supercapacitors • Energy Transformation • Environmental Electrochemistry • Fundamental & Theoretical Electrochemistry • Innovative Methods in Electrochemistry • Organic & Molecular Electrochemistry • Physical & Nano-Electrochemistry • Sensors & Bio-sensors •
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