Single-cell transcriptomics dissecting the development and evolution of nervous system in insects

IF 5.8 1区农林科学 Q1 BIOLOGY Current opinion in insect science Pub Date : 2024-04-10 DOI:10.1016/j.cois.2024.101201

Weiwei Liu , Qiye Li

引用次数: 0

Abstract

Insects can display a vast repertoire of complex and adaptive behaviors crucial for survival and reproduction. Yet, how the neural circuits underlying insect behaviors are assembled throughout development and remodeled during evolution remains largely obscure. The advent of single-cell transcriptomics has opened new paths to illuminate these historically intractable questions. Insect behavior is governed by its brain, whose functional complexity is realized through operations across multiple levels, from the molecular and cellular to the circuit and organ. Single-cell transcriptomics enables dissecting brain functions across all these levels and allows tracking regulatory dynamics throughout development and under perturbation. In this review, we mainly focus on the achievements of single-cell transcriptomics in dissecting the molecular and cellular architectures of nervous systems in representative insects, then discuss its applications in tracking the developmental trajectory and functional evolution of insect brains.

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单细胞转录组学剖析昆虫神经系统的发育与进化

昆虫可以表现出大量复杂的适应性行为，这些行为对昆虫的生存和繁殖至关重要。然而，昆虫行为所依赖的神经回路是如何在整个发育过程中组装起来并在进化过程中重塑的，这在很大程度上仍然是个谜。单细胞转录组学的出现为阐明这些历来难以解决的问题开辟了新的道路。昆虫的行为受大脑支配，其功能的复杂性是通过从分子和细胞到电路和器官等多个层次的操作实现的。单细胞转录组学能够剖析所有这些层次的大脑功能，并跟踪整个发育过程和干扰下的调控动态。在这篇综述中，我们主要关注单细胞转录组学在剖析代表性昆虫神经系统的分子和细胞结构方面取得的成就，然后讨论其在追踪昆虫大脑发育轨迹和功能进化方面的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in insect science BIOLOGYECOLOGYENTOMOLOGY-ECOLOGY

CiteScore

10.40

自引率

1.90%

发文量

113

期刊介绍： Current Opinion in Insect Science is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up–to–date with the expanding volume of information published in the field of Insect Science. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following 11 areas are covered by Current Opinion in Insect Science. -Ecology -Insect genomics -Global Change Biology -Molecular Physiology (Including Immunity) -Pests and Resistance -Parasites, Parasitoids and Biological Control -Behavioural Ecology -Development and Regulation -Social Insects -Neuroscience -Vectors and Medical and Veterinary Entomology There is also a section that changes every year to reflect hot topics in the field. Section Editors, who are major authorities in their area, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors commission articles from leading scientists on each topic that they have selected and the commissioned authors write short review articles in which they present recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.