Gaze and attention: Mechanisms underlying the therapeutic effect of optokinetic stimulation in spatial neglect

IF 2 3区心理学 Q3 BEHAVIORAL SCIENCES Neuropsychologia Pub Date : 2024-04-09 DOI:10.1016/j.neuropsychologia.2024.108883

H.H. Chan , A.G. Mitchell , E. Sandilands , D. Balslev

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Abstract

Left smooth pursuit eye movement training in response to large-field visual motion (optokinetic stimulation) has become a promising rehabilitation method in left spatial inattention or neglect. The mechanisms underlying the therapeutic effect, however, remain unknown. During optokinetic stimulation, there is an error in visual localisation ahead of the line of sight. This could indicate a change in the brain's estimate of one's own direction of gaze. We hypothesized that optokinetic stimulation changes the brain's estimate of gaze. Because this estimate is critical for coding the locus of attention in the visual space relative to the body and across sensory modalities, its change might underlie the change in spatial attention. Here, we report that in healthy participants optokinetic stimulation causes not only a directional bias in the proprioceptive signal from the extraocular muscles, but also a corresponding shift of the locus of attention. Both changes outlasted the period of stimulation. This result forms a step in investigating a causal link between the adaptation in the sensorimotor gaze signals and the recovery in spatial neglect.

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凝视与注意力：视动刺激对空间忽略症的治疗作用机制

针对大视野视觉运动的左侧平滑追随眼动训练（光动刺激）已成为治疗左侧空间注意力不集中或忽视的一种很有前景的康复方法。然而，其治疗效果的内在机制仍然未知。在光动力刺激过程中，视线前方的视觉定位会出现误差。这可能表明大脑对自身注视方向的估计发生了变化。我们假设，光动力刺激会改变大脑对注视方向的估计。由于这种估计对于编码视觉空间中相对于身体和跨感觉模式的注意力位置至关重要，因此它的变化可能是空间注意力变化的基础。在这里，我们报告了在健康的参与者中，光动力刺激不仅会导致来自眼外肌的本体感觉信号出现方向性偏差，还会导致注意力位置的相应移动。这两种变化都会持续一段时间。这一结果为研究感觉运动凝视信号的适应与空间忽略的恢复之间的因果联系迈出了一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychologia 医学-行为科学

CiteScore

5.10

自引率

3.80%

发文量

228

审稿时长

4 months

期刊介绍： Neuropsychologia is an international interdisciplinary journal devoted to experimental and theoretical contributions that advance understanding of human cognition and behavior from a neuroscience perspective. The journal will consider for publication studies that link brain function with cognitive processes, including attention and awareness, action and motor control, executive functions and cognitive control, memory, language, and emotion and social cognition.