The Effect of Mentha spicata Essential Oil (Supermint Oral Drops) on Gastric Residual Volume in Mechanically Ventilated Intensive Care Unit Patients: A Parallel-Group, Triple-Blinded, Randomised, Placebo-Controlled Trial

IF 2.2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Herbal Medicine Pub Date : 2024-04-25 DOI:10.1016/j.hermed.2024.100886
F. Mohammadzadeh , S.S. Bilondi , M. Sahebanmaleki , J. Asari–Sani-Mend , M. Tavakolizadeh , H. Aalami , A. Delshad Noghabi
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Abstract

Introduction

Delayed gastric emptying is a prevalent problem in intensive care unit (ICU) patients on mechanical ventilation receiving enteral nutrition. This study aimed to assess the effect of Mentha spicata essential oil (Supermint oral drops) on gastric residual volume (GRV) in this patient population.

Methods

In this clinical trial study, from May 1, 2020 to January 30, 2021, 60 mechanically ventilated ICU patients were randomly assigned to intervention and control groups. From the first day of their feeding, patients in the intervention and control groups, respectively, received 20 drops of the Supermint and placebo dissolved in 40 ml of water, three times daily for 4 days. The GRV was measured at the baseline and during four days of intervention. Data were analysed using a generalised estimation equation regression model.

Results

Of the patients, 58.1% were female. The mean age of patients was 71.5 (SD = 14.2), and 65.5% were hospitalised for coronavirus disease 2019. The results indicated no significant difference between the two groups in terms of the baseline GRV (P = 0.181). There was a significant interaction between time and the treatment group (P < 0.001), which suggested that GRV changes over time were different between the two groups. In the control group, the average GRV increased by 0.07 for each unit increase in time, while in the Supermint group, it decreased significantly by 1.09.

Conclusions

The current study’s finding suggested that M spicata essential oil may have the potential to reduce GRV in ICU patients undergoing mechanical ventilation. Further studies are needed to confirm this finding.

IRCT code

No: IRCT20191223045868N1. Date: March 28, 2020. Available at: http://irct.ir/trial/46580.

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薄荷精油(超级薄荷口服滴剂)对机械通气重症监护室患者胃剩余容积的影响:平行组、三重盲、随机、安慰剂对照试验
导言胃排空延迟是重症监护病房(ICU)接受肠内营养的机械通气患者普遍存在的问题。本研究旨在评估薄荷精油(Supermint口服滴剂)对该患者群体胃剩余容积(GRV)的影响。方法在这项临床试验研究中,从 2020 年 5 月 1 日至 2021 年 1 月 30 日,60 名接受机械通气的 ICU 患者被随机分配到干预组和对照组。从喂食的第一天起,干预组和对照组的患者分别服用 20 滴溶于 40 毫升水中的 Supermint 和安慰剂,每天三次,连续服用 4 天。在基线和四天的干预期间测量 GRV。数据采用广义估计方程回归模型进行分析。患者的平均年龄为71.5岁(SD = 14.2),65.5%的患者因冠状病毒病住院治疗。结果显示,两组患者的基线 GRV 无明显差异(P = 0.181)。时间与治疗组之间存在明显的交互作用(P <0.001),这表明两组的 GRV 随时间的变化有所不同。在对照组中,时间每增加一个单位,GRV 平均值就会增加 0.07,而在 Supermint 组中,GRV 平均值则会明显下降 1.09。还需要进一步的研究来证实这一发现。日期:2020 年 3 月 28 日2020年3月28日。网址:http://irct.ir/trial/46580。
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来源期刊
Journal of Herbal Medicine
Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
3.90
自引率
0.00%
发文量
94
期刊介绍: The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.
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