Journal of Herbal Medicine最新文献

Clinical outcomes of hospitalised COVID-19 Omicron patients treated with traditional Chinese Medicine: A Retrospective Studymedicine: a retrospective study of a large medical centre in Shanghai, China

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-12-01 DOI: 10.1016/j.hermed.2024.100971

Yafang Guo , Hong Lu , Jialin Zhu , Jianjun Feng , Yonggang Gu , Li Ma , Yunsheng Huang , Chengxing Xu , Xinge Feng , Zhongqiu Wen , Lili Gao , Wujun Xiong , Xuhui Bao , Changming Zhang , Yipeng Zeng

Introduction

The efficacy of Chinese herbal medicine (CHM) in treating infection with the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains to be investigated. This study aimed to assess the efficacy of CHM in COVID-19 Omicron patients.

Methods

Inpatients aged 18 years or older were divided into two groups based on their treatment: Western medicine group (WMG) and CHM group (CHMG). Demographic and COVID-19-related outcome data of the inpatients were collected. We analyzed negative conversion time, hospital stay, and clinical outcomes.

Results

The Asymptomatic Type: Negative conversion time significantly decreased in the CHMG compared with that in the WMG (3.0 [range: 2.0–7.0] days vs 5.0 [range: 3.0–9.0] days, P < 0.01). The hospital stay of the CHMG significantly decreased compared with that of the WMG (6.0 [range: 3.0–11.0] days vs 9.0 [range: 6.0–13.0] days, P < 0.01). The group was independently associated with negative conversion time (P < 0.01). The Mild/Moderate type: Negative conversion time significantly decreased in the CHMG compared with the WMG (6.0 [range: 2.0–11.0] days vs 8.0 [range: 3.0–12.0] days, P < 0.01). The hospital stay of the CHMG significantly decreased compared with that of the WMG (9.0 [range: 5.0–14.0] days vs 11.0 [range: 7.0–16.0] days, P < 0.01).

Conclusion

We found that the use of the JingYinGuBiao formula in Asymptomatic type patients and the JingYinQinHua formula in Mild/Moderate type patients is one of the most effective ways of treating SARS-CoV-2 Omicron infection because it could shorten negative conversion time and hospital stay.

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引用次数: 0

Research progress and modern application analysis of chemical constituents and pharmacological effects of volatile oils in acrid Chinese medicines

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-12-01 DOI: 10.1016/j.hermed.2024.100970

Xinwen Zhu , Xue Geng , Qi Gao , Ping Wang , Dianhua Shi , Yuecheng Liu , Qiang Zhang , Yanpeng Dai , Qian Zhou

Introduction

This review aims to provide a systematic summary of the chemical constituents, pharmacological effects, traditional use, clinical applications and quality control of acrid Chinese medicines to provide a reference for in-depth research and product development of acrid Chinese medicinal volatile oils.

Methods

In this study, the database of CNKI, Web of Science and PubMed were used to search for information on acrid Chinese medicines using the name (Latin name) and ‘volatile oil’.

Results

This review summarises and analyzes the chemical composition and pharmacological effect of 126 kinds of eight types of acrid Chinese medicines. The results show that the main components of the volatile oils used in acrid Chinese medicines are terpenoids and terpenes, followed by alcohols and esters. These components have been used in medicine because of their pharmacological activities.

Conclusions

Volatile oils have a broad spectrum of pharmacological activities. However, due to the complex composition and unstable quality of volatile oils, the wider application of volatile oils is limited; the current quality specifications at all levels lack research on the composition limits and standards of volatile oils. Therefore, establishing corresponding quality control standards should be the key research direction for volatile oils in the future.

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引用次数: 0

Group B Strep During Pregnancy and Allium sativum L.

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-12-01 DOI: 10.1016/j.hermed.2024.100965

Kátia Andrea de Menezes Torres , Sônia Maria Rolim Rosa Lima , Maria Thereza Gamberini , Domingos Sávio Rodrigues , Pedro Ismael Silva Junior

Introduction

Maternal colonisation with Streptococcus agalactiae, or Group B Streptococcus (GBS), during pregnancy increases the risk of neonatal infection through vertical transmission from the mother to the foetus, either before or during labour. This study aimed to evaluate the antimicrobial activity of the Sep-Pak 80% (SP80) fraction derived from Allium sativum L. and its synergistic potential with antibiotics against GBS strains.

Methods

Antimicrobial activity and potential synergism were assessed via broth microdilution and disk diffusion assays. Fifty-five clinical isolates and one American type culture collection (ATCC) strain of GBS were tested with the disk diffusion method to assess the combination of the SP80 fraction with ampicillin and penicillin G. A broth microdilution assay was performed on one ATCC strain.

Results

The minimum inhibitory concentrations of SP80, ampicillin, and penicillin G against Streptococcus agalactiae (ATCC 12386) were 5 mg/mL, 0.01 µg/mL, and 0.06 µg/mL, respectively. The combination of SP80 with antibiotics, assessed through broth microdilution, demonstrated an additive effect. Statistical analysis revealed that the mean inhibition zone for ampicillin, when combined with the SP80 fraction using the disk diffusion method, was greater than that for ampicillin alone, although the difference was not statistically significant. For penicillin G, the mean remained unchanged when it was combined with SP80. The inhibition zones of the isolated antibiotics revealed that the tested strains were more resistant to penicillin G than to ampicillin.

Conclusions

The SP80 fraction exhibits antimicrobial activity against GBS. When combined with antibiotics, it has an additive effect, suggesting that this approach could be promising for combating GBS infections.

{"title":"Group B Strep During Pregnancy and Allium sativum L.","authors":"Kátia Andrea de Menezes Torres , Sônia Maria Rolim Rosa Lima , Maria Thereza Gamberini , Domingos Sávio Rodrigues , Pedro Ismael Silva Junior","doi":"10.1016/j.hermed.2024.100965","DOIUrl":"10.1016/j.hermed.2024.100965","url":null,"abstract":"<div><h3>Introduction</h3><div>Maternal colonisation with <em>Streptococcus agalactiae</em>, or Group B <em>Streptococcus</em> (<strong>GBS</strong>), during pregnancy increases the risk of neonatal infection through vertical transmission from the mother to the foetus, either before or during labour. This study aimed to evaluate the antimicrobial activity of the Sep-Pak 80% (<strong>SP80</strong>) fraction derived from <em>Allium sativum</em> L. and its synergistic potential with antibiotics against GBS strains.</div></div><div><h3>Methods</h3><div>Antimicrobial activity and potential synergism were assessed via broth microdilution and disk diffusion assays. Fifty-five clinical isolates and one American type culture collection (ATCC) strain of GBS were tested with the disk diffusion method to assess the combination of the SP80 fraction with ampicillin and penicillin G. A broth microdilution assay was performed on one ATCC strain.</div></div><div><h3>Results</h3><div>The minimum inhibitory concentrations of SP80, ampicillin, and penicillin G against <em>Streptococcus agalactiae</em> (ATCC 12386) were 5 mg/mL, 0.01 µg/mL, and 0.06 µg/mL, respectively. The combination of SP80 with antibiotics, assessed through broth microdilution, demonstrated an additive effect. Statistical analysis revealed that the mean inhibition zone for ampicillin, when combined with the SP80 fraction using the disk diffusion method, was greater than that for ampicillin alone, although the difference was not statistically significant. For penicillin G, the mean remained unchanged when it was combined with SP80. The inhibition zones of the isolated antibiotics revealed that the tested strains were more resistant to penicillin G than to ampicillin.</div></div><div><h3>Conclusions</h3><div>The SP80 fraction exhibits antimicrobial activity against GBS. When combined with antibiotics, it has an additive effect, suggesting that this approach could be promising for combating GBS infections.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100965"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of flaxseed oil on non-alcoholic fatty liver disease: a randomised controlled trial

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-12-01 DOI: 10.1016/j.hermed.2024.100967

Ali Beheshti Namdar , Delaram Omidvar , Forouzan Amerizadeh , Mona Kabiri , Hediyeh Beheshti Namdar , Sahar Ravanshad

Introduction

Non-Alcoholic Fatty Liver Disease (NAFLD) is a prevalent liver disorder and a leading cause of elevated liver enzymes. Previous research indicates that a diet rich in polyunsaturated fatty acids (PUFAs) can alleviate liver insulin resistance. This study investigates the therapeutic effects of flaxseed oil, a primary PUFA source, on NAFLD treatment.

Methods

In a randomized clinical trial comprising 60 NAFLD patients diagnosed with NAFLD of grades 1, 2, and 3, participants were assigned to either a flaxseed oil capsule or a placebo group, for a total duration of 2 months.

Results

Before the intervention, both groups showed no significant differences in examined parameters. However, after the intervention, the flaxseed oil group exhibited significant improvements in Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), fasting blood sugar (FBS), and total bilirubin, compared to the placebo group. Specifically, reductions were observed in AST (P = 0.010), ALT (P = 0.047), ALP (P < 0.001), FBS (P = 0.016), and total bilirubin (P = 0.004).

Conclusions

These findings suggest that flaxseed oil may hold promise as a therapeutic intervention for NAFLD, highlighting its potential in managing liver disease and metabolic parameters.

{"title":"The efficacy of flaxseed oil on non-alcoholic fatty liver disease: a randomised controlled trial","authors":"Ali Beheshti Namdar , Delaram Omidvar , Forouzan Amerizadeh , Mona Kabiri , Hediyeh Beheshti Namdar , Sahar Ravanshad","doi":"10.1016/j.hermed.2024.100967","DOIUrl":"10.1016/j.hermed.2024.100967","url":null,"abstract":"<div><h3>Introduction</h3><div>Non-Alcoholic Fatty Liver Disease (NAFLD) is a prevalent liver disorder and a leading cause of elevated liver enzymes. Previous research indicates that a diet rich in polyunsaturated fatty acids (PUFAs) can alleviate liver insulin resistance. This study investigates the therapeutic effects of flaxseed oil, a primary PUFA source, on NAFLD treatment.</div></div><div><h3>Methods</h3><div>In a randomized clinical trial comprising 60 NAFLD patients diagnosed with NAFLD of grades 1, 2, and 3, participants were assigned to either a flaxseed oil capsule or a placebo group, for a total duration of 2 months.</div></div><div><h3>Results</h3><div>Before the intervention, both groups showed no significant differences in examined parameters. However, after the intervention, the flaxseed oil group exhibited significant improvements in Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), fasting blood sugar (FBS), and total bilirubin, compared to the placebo group. Specifically, reductions were observed in AST (<em>P</em> = 0.010), ALT (<em>P</em> = 0.047), ALP (<em>P</em> < 0.001), FBS (<em>P</em> = 0.016), and total bilirubin (<em>P</em> = 0.004).</div></div><div><h3>Conclusions</h3><div>These findings suggest that flaxseed oil may hold promise as a therapeutic intervention for NAFLD, highlighting its potential in managing liver disease and metabolic parameters.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100967"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating efficacy and safety of Saffron add-on treatment in improvement of motor and depressive symptoms of patients with Parkinson’s disease: A randomized, double-blind, placebo-controlled clinical trial 评估藏红花附加治疗在改善帕金森病患者运动和抑郁症状方面的疗效和安全性：随机、双盲、安慰剂对照临床试验

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-11-13 DOI: 10.1016/j.hermed.2024.100968

Vahirezad Lalezari , Vajiheh Aghamollaii , Ahmadreza Moslehi , Amir Najafi , Mohammadamin Parsaei , Alireza Beikmarzehei , Hossein Sanjari Moghaddam , Amir Hossein Abdolghaffari , Shahin Akhondzadeh

Aim

Evidence has highlighted neuroprotective effects of saffron in animal models of Parkinson’s disease (PD). The present study investigated the efficacy and safety of add-on saffron on motor and depressive symptoms of patients with PD.

Methods

This study was an 8-week, randomized, double-blind, and parallel-group clinical trial. Known cases of PD with depression were randomized to receive either a routine treatment (levodopa or levodopa-equivalent dose of a dopamine agonist) plus saffron capsule (15 mg bid) or routine treatment plus placebo. All participants were assessed using the Hamilton Depression Rating Scale (HAMD), Geriatric Depression Scale-30 (GDS-30), item 3 of Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part 1, MDS-UPDRS part 3, and H and Y scale at baseline and at week 8.

Results

A total of 52 patients (25 in saffron and 27 in placebo groups) were included. Our results demonstrated that saffron could not improve motor symptoms of PD patients (F=0.53, df=1, p=0.424). However, repeated-measures analysis showed a significant effect of time

\times

treatment (F=8.24, df=1, p=0.006) on HAMD scores, indicating a greater improvement of depressive symptoms in saffron compared to placebo groups. Our study showed nonsignificant findings regarding the secondary outcome measures (GDS-30, item 3 of MDS-UPDRS part 1, and H and Y scale). We showed that treatment with saffron is safe in PD.

Conclusion

We substantiated that add-on treatment with saffron significantly improved depression, but not motor symptoms, in PD. Further trials with larger sample sizes and longer follow-ups are needed to confirm our findings.

目的有证据表明藏红花在帕金森病（PD）动物模型中具有神经保护作用。本研究调查了添加藏红花对帕金森病患者运动症状和抑郁症状的疗效和安全性。方法本研究是一项为期 8 周的随机、双盲、平行组临床试验。已知的伴有抑郁的帕金森氏症病例被随机分配接受常规治疗（左旋多巴或左旋多巴等效剂量的多巴胺激动剂）加藏红花胶囊（15 毫克 bid）或常规治疗加安慰剂。所有参与者在基线和第8周时均接受了汉密尔顿抑郁量表（HAMD）、老年抑郁量表-30（GDS-30）、运动障碍协会统一帕金森病评分量表（MDS-UPDRS）第1部分第3项、MDS-UPDRS第3部分以及H和Y量表的评估。结果表明，藏红花不能改善帕金森病患者的运动症状（F=0.53，df=1，P=0.424）。然而，重复测量分析表明，时间×治疗（F=8.24，df=1，p=0.006）对HAMD评分有显著影响，表明藏红花组比安慰剂组对抑郁症状的改善更大。我们的研究显示，次要结果测量（GDS-30、MDS-UPDRS 第 1 部分第 3 项以及 H 和 Y 量表）的结果不显著。结论我们证实了藏红花附加治疗能显著改善帕金森病患者的抑郁，但不能改善运动症状。要证实我们的研究结果，还需要进行样本量更大、随访时间更长的进一步试验。

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引用次数: 0

Comparing Urtica dioica to placebo on vaginal cytology and pH in postmenopausal women: A randomized, controlled trial 比较荨麻和安慰剂对绝经后妇女阴道细胞学和 pH 值的影响：随机对照试验

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-11-13 DOI: 10.1016/j.hermed.2024.100964

Nahid Nazari , Fatemeh Zahra Karimi , Hassan Rakhshandeh , Seyed Reza Mazloom , Ramin Azarhoush

Introduction

Decreased estrogen in the period of menopause causes thinning of the vaginal lining, a rise in vaginal acidity, and a drop in vaginal maturation levels. Menopausal women are seeking treatment for bothersome vaginal symptoms, opting for herbal treatments instead of hormone therapy due to their side effects or contraindications.

Methods

In 2021–2022, a triple-blind randomized placebo-controlled clinical trial was carried out on 84 postmenopausal women aged 45–60 from Golestan who had the eligibility criteria and sought services from comprehensive health centers. The qualified females were given 5% vaginal cream containing Urtica dioica extract and a placebo for a duration of 8 weeks. Analysis of data was performed with SPSS. Vaginal PH and maturation value were measured before, as well as four and eight weeks following the intervention.

Results

Before the intervention, there was no significant difference in the mean (SD) scores of the vaginal pH and VMV between the two groups. During the fourth and eighth weeks post-intervention in the Urtica dioica group, the mean (SD) vaginal pH scores were 4.8 ± 0.7 and 4.3 ± 1.0, and also the mean (SD) VMV scores were 50.8 ± 8.8 and 51.3 ± 8.9, respectively. There was a significant difference between the intervention group and the placebo group (P<0.001).

Conclusions

After using Urtica dioica vaginal cream for eight weeks, postmenopausal women displayed higher vaginal maturation value and lower vaginal pH.

引言绝经期雌激素减少会导致阴道内膜变薄、阴道酸度上升和阴道成熟度下降。2021-2022 年，一项三盲随机安慰剂对照临床试验在戈勒斯坦地区的 84 名 45-60 岁绝经后妇女中展开，这些妇女符合资格标准，并在综合保健中心就诊。符合条件的女性在 8 周内服用了含 5%荨麻提取物的阴道乳膏和安慰剂。数据分析采用 SPSS 软件进行。结果干预前，两组女性阴道 pH 值和阴道成熟度的平均值（标清）无显著差异。干预后第四周和第八周，荨麻组阴道 pH 值的平均值（标清）分别为 4.8 ± 0.7 和 4.3 ± 1.0，VMV 值的平均值（标清）分别为 50.8 ± 8.8 和 51.3 ± 8.9。结论使用荨麻阴道霜八周后，绝经后妇女的阴道成熟度值升高，阴道 pH 值降低。

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引用次数: 0

Phytochemical examination of Cistus laurifolius extract and its impact on cytotoxicity, apoptosis and oxidative stress in colorectal and breast cancer cell lines 肉苁蓉提取物的植物化学研究及其对结直肠癌和乳腺癌细胞系的细胞毒性、细胞凋亡和氧化应激的影响

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-11-07 DOI: 10.1016/j.hermed.2024.100966

Fatma Yildiz , Hamiyet Eciroglu Sarban , Fatma Gonca Kocanci , Meltem Gungor , Ersin Yucel , Dilge Yucel

Introduction

Colon and breast cancer are the most common types of cancer worldwide. This study investigatesd the anticancer properties of Cistus laurifolius L. leaf extract on breast cancer (MCF-7) and human colon cancer (Caco-2) cell lines.

Methods

The research involved meticulous collection, drying and processing of C. laurifolius leaves to extract bioactive compounds, subsequently analyzed for phenolic content using advanced LC-MS/MS technology. Cell viability of the extract on MCF-7 and Caco-2 cells was demonstrated by MTT test. Levels of critical apoptotic markers (Bad, Bax/Bcl-2, Bax/Bcl-xl, Caspase-9) and Total Antioxidant Capacity (TAC) and Total Oxidant Capacity (TOC), which affect the antioxidant system, were evaluated by the ELISA method. Identification of phenolic compounds, including quercetin and rutin, through target prediction analysis enriches our understanding of bioactive molecules.

Results

The results of the study showed that C. laurifolius extract inhibited cell proliferation time and dose-dependent on Caco-2 and MCF-7 cells (P<0.05). TAC, Bax/Bcl-2 and Bax/Bcl-xl ratios in MCF-7 and Caco-2 cells increased in a dose-dependent manner compared to the control group. In MCF-7 cells, TAC (p<0.05; p<0.01), Bax/Bcl-2 (p<0.001; p<0.0001) and Bax-Bcl-xl (p<0.01) ratios increased at 24 h compared to the control group. In Caco-2 cells, TAC (p<0.001), Bax/Bcl-2 ratios increased at 48 h (p<0.05), while Bax-Bcl-xl ratios decreased (p<0.01; p<0.001) compared to the control group.

Conclusion

C. laurifolius leaf extracts emerge as a promising anticancer candidate, hindering cell proliferation and inducing apoptosis in colon and breast cancer cells. The classification of bioactive molecules may facilitate further clinical therapeutic interventions targeting colon and breast cancer.

导言结肠癌和乳腺癌是全球最常见的癌症类型。本研究调查了 Cistus laurifolius L. 叶提取物对乳腺癌（MCF-7）和人类结肠癌（Caco-2）细胞系的抗癌特性。通过 MTT 测试证明了提取物对 MCF-7 和 Caco-2 细胞的细胞活力。采用 ELISA 方法评估了重要的细胞凋亡标志物（Bad、Bax/Bcl-2、Bax/Bcl-xl、Caspase-9）以及影响抗氧化系统的总抗氧化能力（TAC）和总氧化能力（TOC）的水平。结果研究结果表明，月桂叶豚草提取物对 Caco-2 和 MCF-7 细胞的增殖抑制作用与时间和剂量有关（P<0.05）。与对照组相比，MCF-7 和 Caco-2 细胞中的 TAC、Bax/Bcl-2 和 Bax/Bcl-xl 比率呈剂量依赖性增加。在 MCF-7 细胞中，与对照组相比，TAC（p<0.05; p<0.01）、Bax/Bcl-2（p<0.001; p<0.0001）和 Bax-Bcl-xl （p<0.01）比率在 24 小时后增加。在 Caco-2 细胞中，与对照组相比，TAC 组（p<0.001）、Bax/Bcl-2 比值在 48 小时后增加（p<0.05），而 Bax-Bcl-xl 比值则下降（p<0.01; p<0.001）。生物活性分子的分类可能有助于针对结肠癌和乳腺癌的进一步临床治疗干预。

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引用次数: 0

Jing-Si herbal tea attenuates oral cancer cell viability, migration, and invasion by regulating epithelial-to-mesenchymal transition and reactive oxygen species accumulation 京四凉茶通过调节上皮细胞向间质转化和活性氧积累，降低口腔癌细胞的活力、迁移和侵袭能力

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-11-07 DOI: 10.1016/j.hermed.2024.100969

Po-Chih Hsu , Chia-Chen Hsu , Yi-Jan Hsia , Chan-Yen Kuo

Introduction

Oral cancer is the sixth most common cancer worldwide and can be life-threatening if not diagnosed and treated in its early stages. Jing-Si herbal tea (JSHT), containing eight traditional Chinese medicine-based herbs, is known to suppress the malignancy, growth, and metastasis of several tumour cells, including breast, lung, and colon cancer cells. However, the pharmacological effect of JSHT on oral cancer progression is still unclear.

Methods

In this study, we evaluated the potential of JSHT to arrest the development of oral cancer via induction of cell death by reactive oxygen species (ROS) accumulation and inhibition of migration, invasion, and epithelial-to-mesenchymal transition (EMT). For this purpose, we employed the human tongue squamous cell carcinoma human tongue squamous carcinoma cell line, which we treated with different JSHT concentrations for 24 hours, and assessed cell viability, migration, and wound healing capabilities, together with western blotting for measuring expression levels of EMT markers.

Results

Survival, migration/invasion ability, EMT, and ROS production in the human tongue squamous carcinoma human tongue squamous carcinoma and FaDu human pharynx squamous cell carcinoma cell line were decreased by JSHT treatment via Lon protease-independent mechanisms.

Conclusion

This study demonstrates that JSHT could be regarded as a candidate new supplement to existing anticancer therapies and an alternative, orally administered healthcare product for treating oral squamous cell carcinoma.

导言口腔癌是全球第六大常见癌症，如果不在早期诊断和治疗，可能会危及生命。京四凉茶（JSHT）含有八种传统中药材，可抑制多种肿瘤细胞（包括乳腺癌、肺癌和结肠癌细胞）的恶性、生长和转移。在这项研究中，我们评估了 JSHT 通过活性氧（ROS）积累诱导细胞死亡以及抑制迁移、侵袭和上皮细胞向间质转化（EMT）来阻止口腔癌发展的潜力。为此，我们采用了人舌鳞癌细胞株，用不同浓度的 JSHT 处理 24 小时，评估细胞存活率、迁移和伤口愈合能力，并用 Western 印迹法测定 EMT 标记物的表达水平。结果人舌鳞癌人舌鳞癌和 FaDu 人咽鳞癌细胞株的存活率、迁移/侵袭能力、EMT 和 ROS 产生均因 JSHT 处理而降低，其机制与 Lon 蛋白酶无关。

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引用次数: 0

Traditional use of medicinal plants in Brazil to treat mycosis, antifungal activity, and their nanomaterials against Trichophyton rubrum 巴西治疗真菌病的传统药用植物、抗真菌活性及其纳米材料对红色毛癣菌的作用

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-10-24 DOI: 10.1016/j.hermed.2024.100961

José Jailson Lima Bezerra , Viviane Bezerra da Silva , Douglas Dourado

Introduction

Mycosis are health problems that affects the global population. Current treatments have used synthetic drugs with several side effects. To overcome these drawbacks, medicinal plants have been investigated as a promising alternative to this problem, and these can be associated with nanotechnology. Thus, this study brought together, for the first time, information from the literature on the traditional use of plants to treat mycosis in Brazil, antifungal potential against Trichophyton rubrum, phytochemistry, nanomaterials, and toxicity.

Methods

We reviewed the literature since the first report in 2002 on the traditional use of medicinal plants to treat mycosis in Brazil until May 2024.

Results

According to the scientific documents analyzed, traditional communities in Brazil use 87 plant species distributed in 43 families to treat mycosis. Among these 87 species, only 29 have been evaluated for in vitro antifungal efficacy against T. rubrum. Citral, ethyl cinnamate, eugenol, linalool, thymol, and ricinine isolated from Brazilian medicinal plants were effective against this dermatophyte. Furthermore, we noted that seven species were associated with nanomaterials (nine nanoparticles and one nanoemulsion).

Conclusion

The development of new antifungals to treat onychomycosis caused by T. rubrum based on medicinal plants should be explored since these phytochemicals show advantages over synthetic treatments. Moreover, when associated with nanotechnological strategies, these natural products can have improved physicochemical and biological properties, proving to be promising tools against onychomycosis.

导言霉菌病是影响全球人口的健康问题。目前的治疗方法是使用具有多种副作用的合成药物。为了克服这些弊端，人们对药用植物进行了研究，并将其与纳米技术结合起来，作为解决这一问题的一种有前途的替代方法。因此，本研究首次汇集了有关巴西利用植物治疗真菌病的传统方法、对红色毛癣菌的抗真菌潜力、植物化学、纳米材料和毒性等方面的文献信息。结果根据所分析的科学文献，巴西传统社区利用分布在 43 个科的 87 种植物来治疗真菌病。在这 87 种植物中，只有 29 种对红念珠菌的体外抗真菌功效进行了评估。从巴西药用植物中分离出的柠檬醛、肉桂酸乙酯、丁香酚、芳樟醇、百里酚和蓖麻碱对这种皮肤真菌有效。此外，我们还注意到有 7 个物种与纳米材料（9 个纳米颗粒和 1 个纳米乳液）有关。结论应探索开发新的抗真菌药物，以药用植物为基础治疗由红癣菌引起的甲癣，因为这些植物化学物质显示出优于合成疗法的优势。此外，当与纳米技术策略相结合时，这些天然产品的物理化学和生物学特性会得到改善，从而证明它们是治疗甲癣的有前途的工具。

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引用次数: 0

Chinese Herbal Bath for Eczema: A Systematic Review and Meta-analysis of 39 Randomised Controlled Trials 治疗湿疹的中药浴：39 项随机对照试验的系统回顾和元分析

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-10-23 DOI: 10.1016/j.hermed.2024.100959

Yiran Chen , Xiaoxuan Ma , Xiaoya Fei , Ying Luo , Yue Luo , Xin Ma , Le Kuai , Bin Li , Bin Fan , Xiaojie Ding

Introduction

Chinese herbal bath (CHB) shows promise in treating eczema, but high-grade clinical evidence is lacking. This review aims to systematically evaluate the efficacy and safety of CHB in the treatment of eczema.

Methods

PubMed, Embase, Cochrane Library, China Network Knowledge Infrastructure, VIP Chinese Journal Service Platform, and Wan Fang Database were searched for Randomised controlled trials comparing CHB with non-CHB interventions for eczema. RevMan5.4 software was used to calculate the 95% confidence interval (CI) risk ratio (RR) and perform meta-analysis.

Results

Our meta-analysis incorporated data from 39 randomised controlled trials, demonstrating CHB's enhanced efficacy over conventional therapy (RR, 1.15; 95% CI, 1.11–1.20; P < 0.00001) and improved outcomes when used in conjunction with conventional therapy (RR, 1.14; 95% CI, 1.09–1.19; P < 0.00001). Significant improvements were observed in Eczema Area Severity Index scores (mean difference [MD], −1.04; 95% CI, −1.50 to −0.59; P < 0.00001), visual analogue scale scores (MD, −0.61; 95% CI, −0.64 to −0.58; P < 0.00001), and Dermatology Life Quality Index scores (MD, −1.15; 95% CI, −1.68 to −0.61; P < 0.00001), alongside a lower recurrence rate (RR, 0.24; 95% CI, 0.14–0.41; P < 0.00001) without an increased risk of adverse events. Additionally, immunological marker analysis revealed significant modulatory effects on the immune response.

Conclusions

Chinese herbal bath represents a safe and effective alternative for eczema treatment, offering significant clinical improvements and potential immunological benefits. Future research should focus on larger, high-quality randomised controlled trials and detailed biochemical analyses of CHB formulations to further validate these findings and explore the mechanisms of action.

导言中药浴（CHB）在治疗湿疹方面具有良好的前景，但目前尚缺乏高质量的临床证据。方法检索PubMed、Embase、Cochrane图书馆、中国知网、VIP中文期刊服务平台和万方数据库中比较中药浴与非中药浴干预治疗湿疹的随机对照试验。结果我们的荟萃分析纳入了39项随机对照试验的数据，结果显示CHB的疗效优于常规疗法（RR，1.15；95% CI，1.11-1.20；P <；0.00001），与常规疗法联合使用时，疗效也有所改善（RR，1.14；95% CI，1.09-1.19；P <；0.00001）。湿疹面积严重性指数评分（平均差 [MD]，-1.04；95% CI，-1.50 至 -0.59；P <；0.00001）、视觉模拟量表评分（MD，-0.61；95% CI，-0.64 至 -0.58；P <；0.00001）和皮肤科生活质量指数评分（MD，-1.15；95% CI，-1.68 至 -0.61；P <；0.00001），同时复发率较低（RR，0.24；95% CI，0.14 至 0.41；P <；0.00001），而不良事件风险未增加。结论中药浴是治疗湿疹的一种安全有效的替代疗法，能显著改善临床症状，并具有潜在的免疫学益处。未来的研究应侧重于更大规模、高质量的随机对照试验和中药浴配方的详细生化分析，以进一步验证这些发现并探索其作用机制。

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