Journal of Herbal Medicine最新文献

Salvizan gel for prevention of chemotherapy-induced oral mucositis: a randomised, double-blind, placebo-controlled trial Salvizan凝胶预防化疗引起的口腔黏膜炎：一项随机、双盲、安慰剂对照试验

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2026-03-01 Epub Date: 2026-01-28 DOI: 10.1016/j.hermed.2026.101091

Kiumarth Amini , Monireh Maham , Ali Adeli , Mansour Rajabi Vahid , Hossein Ammarlou

Introduction

Oral mucositis is a serious and common complication of chemotherapy in patients with cancer, for which definitive treatments are lacking. Effective management is therefore crucial. Salvia officinalis L. possesses antioxidant and anti-inflammatory properties and may have preventive effects on this complication. This randomised, double-blind, placebo-controlled clinical trial evaluated the effectiveness of Salvizan gel (containing 28% hydroalcoholic extract of S. officinalis) in preventing chemotherapy-induced oral mucositis.

Methods

Thirty-eight patients with gastrointestinal cancers were randomised to the Salvizan gel group (n = 18) or placebo (n = 20). The severity of oral mucositis was assessed using Common Terminology Criteria for Adverse Events (CTCAE) v5.0 and World Health Organization criteria, and mucositis-related pain was measured with a visual analogue scale. Secondary outcomes included xerostomia and ageusia, as well as changes in food intake type (solid, liquid, semisolid, or inability). Assessments were performed weekly for four weeks. Data were analysed with SPSS version 26.

Results

Salvizan gel reduced the severity of oral mucositis according to CTCAE v5.0 and World Health Organization criteria during weeks 1 and 3. It also significantly reduced mucositis-related pain in week 1 and showed a notable reduction in week 2. Patients in the Salvizan group were better able to consume solid foods, and xerostomia associated with mucositis was significantly lower in this group. There was no significant effect of Salvizan gel on ageusia.

Conclusion

Salvizan gel demonstrates short-term protective effects against chemotherapy-induced oral mucositis in patients with cancer and may be considered as an adjunct in treatment protocols for this complication. However, clinical studies with larger sample sizes are strongly recommended in this regard.

IRCT code

IRCT20211029052907N4

Ethical code

IR.ZUMS.REC.1403.088

口腔黏膜炎是癌症患者化疗后常见的严重并发症，目前尚无明确的治疗方法。因此，有效的管理至关重要。鼠尾草具有抗氧化和抗炎作用，可能对该并发症有预防作用。这项随机、双盲、安慰剂对照的临床试验评估了Salvizan凝胶（含有28% officinalis水酒精提取物）预防化疗引起的口腔黏膜炎的有效性。方法38例胃肠道肿瘤患者随机分为Salvizan凝胶组（n = 18）和安慰剂组（n = 20）。使用不良事件通用术语标准（CTCAE） v5.0和世界卫生组织标准评估口腔黏膜炎的严重程度，并使用视觉模拟量表测量粘膜炎相关疼痛。次要结局包括口干和衰老，以及食物摄入类型的改变（固体、液体、半固体或不能进食）。评估每周进行一次，为期四周。数据采用SPSS version 26进行分析。结果salvizan凝胶在第1周和第3周可降低口腔黏膜炎的严重程度，符合CTCAE v5.0和世界卫生组织标准。在第1周明显减轻粘膜炎相关疼痛，并在第2周明显减轻。Salvizan组的患者能够更好地食用固体食物，并且与粘膜炎相关的口干症在该组中显著降低。丹参凝胶对老年痴呆无显著影响。结论salvizan凝胶对癌症患者化疗引起的口腔黏膜炎具有短期保护作用，可作为该并发症的辅助治疗方案。然而，在这方面，强烈建议进行更大样本量的临床研究。IRCT代码：irct20211029052907n4伦理代码：zums . rec .1403.088

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引用次数: 0

Ethnobotanical insights into the use of medicinal plants for COVID-19 prevention and treatment in Teziutlán, Puebla, México 在Teziutlán、普埃布拉、墨西哥等地利用药用植物预防和治疗COVID-19的民族植物学见解

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2026-03-01 Epub Date: 2025-12-24 DOI: 10.1016/j.hermed.2025.101085

Ana Liviere Vargas-Vizuet , Enrique Aguilar-Muñoz , Carlos Alberto Lobato-Tapia

Introduction

The COVID-19 pandemic underscored the fragility of healthcare systems worldwide and renewed interest in complementary approaches to disease management. In the mountainous region of Teziutlán, Puebla (México), traditional herbal medicine has played a significant role in community-based responses to SARS-CoV-2 infection.

Methods

This cross-sectional ethnobotanical study aimed to document the medicinal plants used for the prevention and treatment of COVID-19 symptoms by traditional healers and laypersons with experiential knowledge. Data collection was conducted in two phases: semistructured interviews with 38 individuals, including 13 traditional healers, and structured surveys administered to 221 patients at a local health center.

Results

A total of 36 plant-based ingredients were identified, with espinosilla (Loeselia mexicana (Lam) Brandegee), garlic (Allium sativum), ginger (Zingiber officinale), lemon (Citrus limon), cinnamon (Cinnamomum verum), and elderberry (Sambucus spp.) among the most frequently cited. Leaves, bulbs, and rhizomes were the most used plant parts, primarily prepared through infusions and decoctions. While most respondents reported no adverse effects, some highlighted potential gastrointestinal or dermatological reactions. Relative frequency of citation analyses showed high consensus on key species.

Conclusion

These findings provide a foundational inventory of species for future pharmacological evaluation and highlight the cultural continuity and relevance of traditional medicine in times of health crises.

2019冠状病毒病大流行凸显了全球卫生保健系统的脆弱性，重新引起了人们对疾病管理补充方法的关注。在普埃布拉（macimxico） Teziutlán山区，传统草药在社区应对SARS-CoV-2感染方面发挥了重要作用。方法采用横断面民族植物学研究方法，记录传统治疗师和外行经验知识人员用于预防和治疗COVID-19症状的药用植物。数据收集分两个阶段进行：对38个人进行半结构化访谈，其中包括13名传统治疗师，以及对当地卫生中心的221名患者进行结构化调查。结果共鉴定出36种植物性成分，其中最常被引用的植物性成分有黄皮草（Loeselia mexicana (Lam) Brandegee）、大蒜（Allium sativum）、姜（Zingiber officinale）、柠檬（Citrus limon）、肉桂（Cinnamomum verum）和接骨木果（Sambucus spp.）。叶、球茎和根茎是最常用的植物部位，主要通过浸剂和煎剂制备。虽然大多数受访者报告没有不良反应，但一些人强调了潜在的胃肠道或皮肤反应。对关键物种的相对被引频次分析显示出较高的一致性。结论这些发现为未来的药理学评估提供了基础物种清单，并突出了传统医学在健康危机时期的文化连续性和相关性。

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引用次数: 0

Effectiveness of herbal medicine for lumbar herniated intervertebral disc with active controls: a systematic review and meta-analysis 中药治疗腰椎间盘突出症的疗效：一项系统回顾和荟萃分析

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/j.hermed.2026.101092

Hongwook Choi , Sook-Hyun Lee , Yoon Jae Lee , Jung-Hyun Kim , Byung-Kwan Seo , In-Hyuk Ha

Background

Lumbar herniated intervertebral disc (LHIVD) is a common global condition, with a lifetime prevalence of up to 40%. Herbal medicine (HM), a representative treatment in complementary and alternative medicine, is considered effective and safe. This study systematically reviewed the effects of HM in alleviating pain and improving functional outcomes in patients with LHIVD.

Methods

This systematic review utilised domestic and international databases up to June 2024. Only randomised controlled trials (RCTs) involving adult patients with LHIVD were included. Two independent reviewers screened studies; a meta-analysis was performed to evaluate the efficacy and safety of HM decoctions.

Results

Overall, 23 RCTs involving Chinese HMs were included (HM monotherapy, 5; HM+traditional Chinese medicine, 12; and HM+usual care, 6). For pain reduction, HM+usual care showed an improvement on visual analogue scale scores (standardised mean difference: −2.00; 95% confidence interval [CI], −2.86 to −1.15). Functional improvement was the most notable in the HM+traditional Chinese medicine group (standardised mean difference: 1.58; 95% CI, 1.20–1.96). HM add-on therapy significantly improved the total effective rate (risk ratio: 1.20; 95% CI, 1.16–1.25). Among the few studies reporting safety, no severe adverse events were associated with HM, although the evidence was insufficient for firm safety-related conclusions.

Conclusion

HM add-on therapy may alleviate pain and improve function in patients with LHIVD, with a relatively low incidence of adverse events, indicating its potential efficacy and acceptable safety profile. However, rigorous large-scale RCTs are necessary to validate HM clinical efficacy.

Protocol registration

PROSPERO (CRD42023415800)

背景：腰椎间盘突出症（LHIVD）是一种常见的全球疾病，终生患病率高达40%。草药治疗是补充和替代医学中具有代表性的治疗方法，被认为是有效和安全的。本研究系统地回顾了HM在缓解LHIVD患者疼痛和改善功能预后方面的作用。方法采用截至2024年6月的国内外数据库进行系统评价。仅纳入了涉及成年LHIVD患者的随机对照试验（RCTs）。两名独立评审员对研究进行了筛选；采用meta分析评价HM煎剂的疗效和安全性。结果共纳入23项涉及中医的随机对照试验（中医单药5项，中医+中药12项，中医+常规护理6项）。在减轻疼痛方面，HM+常规护理在视觉模拟量表评分上有改善（标准化平均差：−2.00；95%可信区间[CI]，−2.86至−1.15）。HM+中药组功能改善最为显著（标准化平均差：1.58;95% CI, 1.20-1.96）。HM附加治疗显著提高了总有效率（风险比：1.20;95% CI, 1.16-1.25）。在少数报告安全性的研究中，虽然证据不足以得出与安全性相关的确切结论，但没有与HM相关的严重不良事件。结论hm附加治疗可减轻LHIVD患者的疼痛和改善功能，不良事件发生率相对较低，提示其潜在的疗效和可接受的安全性。然而，需要严格的大规模随机对照试验来验证HM的临床疗效。协议注册prospero （CRD42023415800）

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引用次数: 0

Indigenous knowledge of medicinal plants used to treat various respiratory problems in rural areas of KwaDlangezwa, KwaZulu-Natal, South Africa 南非夸祖鲁-纳塔尔省KwaDlangezwa农村地区用于治疗各种呼吸道疾病的药用植物的土著知识

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2026-03-01 Epub Date: 2026-02-18 DOI: 10.1016/j.hermed.2026.101093

Mmbulaheni Ramulondi , Nontobeko Zwane

Introduction

Indigenous knowledge has long been crucial for health and healing, significantly impacting healthcare in areas with limited access to conventional treatments. The COVID-19 pandemic emphasised the importance of this knowledge, particularly regarding medicinal plants. Given the ongoing challenge of communicable respiratory diseases, there is a pressing need to document this indigenous knowledge. This study aimed to explore and document indigenous knowledge of medicinal plants used to treat respiratory problems within the KwaDlangezwa region.

Methods

Semistructured interviews were conducted with 100 participants selected based on their willingness to contribute, and data were analysed using descriptive statistics and quantitative analysis.

Results

The study revealed that 99% of participants had knowledge of medicinal plants for treating respiratory diseases. A total of 34 plant species from 23 families were identified for the treatment of 16 respiratory problems. The Asteraceae family was the most noted family. The five most frequently cited species were Tetradenia riparia, Lippia javanica, Eucalyptus spp., Melia azedarach, and Aloe marlothii. Berkheya speciosa, Carpobrotus dimidiatus, Diospyrus galpinii, Eucomis bicolor, Hypoxis argentea, Phoenix reclinata, Searsia pentheri, Solanum campylacanthum, and Vernicia fordii were recorded for the first time to treat respiratory problems. Additionally, three Zulu vernacular names (ucukudwane, umgwaqeni, and umanqandisi) were found to be undocumented in existing literature.

Conclusion

This research highlights the wealth of indigenous knowledge present in KwaDlangezwa regarding medicinal plants for respiratory treatment, emphasising the need for ongoing preservation and documentation of this indigenous knowledge.

长期以来，土著知识对健康和治疗至关重要，对获得常规治疗机会有限的地区的医疗保健产生了重大影响。2019冠状病毒病大流行强调了这方面知识的重要性，特别是关于药用植物的知识。鉴于传染性呼吸道疾病的持续挑战，迫切需要记录这一土著知识。本研究旨在探索和记录KwaDlangezwa地区用于治疗呼吸系统疾病的药用植物的土著知识。方法采用半结构化访谈法，选取100名受访人员，采用描述性统计和定量分析相结合的方法对数据进行分析。结果研究显示，99%的参与者对治疗呼吸系统疾病的药用植物有所了解。共鉴定出23科34种植物，用于治疗16种呼吸道疾病。菊科是最著名的科。被引频次最高的5种分别为：滨水四种（Tetradenia riparia）、javanica Lippia、Eucalyptus spp、苦楝（Melia azedarach）和芦荟（Aloe marlothii）。首次记录到治疗呼吸系统疾病的植物有柏树（Berkheya speciosa）、龙爪鱼（Carpobrotus dimidiatus）、龙爪鱼（Diospyrus galpinii）、双色杜仲（Eucomis bicolia argentea）、凤凰花（Phoenix reclinata）、pentheri Searsia pentheri、campylacanthum、fordii Vernicia fordii。此外，三个祖鲁方言名字（ucukudwane， umgwaqeni和umanqandisi）被发现在现有文献中没有记载。结论本研究突出了KwaDlangezwa存在的丰富的关于呼吸治疗药用植物的土著知识，强调了对这些土著知识进行持续保存和记录的必要性。

{"title":"Indigenous knowledge of medicinal plants used to treat various respiratory problems in rural areas of KwaDlangezwa, KwaZulu-Natal, South Africa","authors":"Mmbulaheni Ramulondi , Nontobeko Zwane","doi":"10.1016/j.hermed.2026.101093","DOIUrl":"10.1016/j.hermed.2026.101093","url":null,"abstract":"<div><h3>Introduction</h3><div>Indigenous knowledge has long been crucial for health and healing, significantly impacting healthcare in areas with limited access to conventional treatments. The COVID-19 pandemic emphasised the importance of this knowledge, particularly regarding medicinal plants. Given the ongoing challenge of communicable respiratory diseases, there is a pressing need to document this indigenous knowledge. This study aimed to explore and document indigenous knowledge of medicinal plants used to treat respiratory problems within the KwaDlangezwa region.</div></div><div><h3>Methods</h3><div>Semistructured interviews were conducted with 100 participants selected based on their willingness to contribute, and data were analysed using descriptive statistics and quantitative analysis.</div></div><div><h3>Results</h3><div>The study revealed that 99% of participants had knowledge of medicinal plants for treating respiratory diseases. A total of 34 plant species from 23 families were identified for the treatment of 16 respiratory problems. The Asteraceae family was the most noted family. The five most frequently cited species were <em>Tetradenia riparia</em>, <em>Lippia javanica</em>, <em>Eucalyptus spp</em>., <em>Melia azedarach</em>, and <em>Aloe marlothii</em>. <em>Berkheya speciosa</em>, <em>Carpobrotus dimidiatus</em>, <em>Diospyrus galpinii, Eucomis bicolor</em>, <em>Hypoxis argentea</em>, <em>Phoenix reclinata</em>, <em>Searsia pentheri</em>, <em>Solanum campylacanthum</em>, and <em>Vernicia fordii</em> were recorded for the first time to treat respiratory problems. Additionally, three Zulu vernacular names (ucukudwane, umgwaqeni, and umanqandisi) were found to be undocumented in existing literature.</div></div><div><h3>Conclusion</h3><div>This research highlights the wealth of indigenous knowledge present in KwaDlangezwa regarding medicinal plants for respiratory treatment, emphasising the need for ongoing preservation and documentation of this indigenous knowledge.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"56 ","pages":"Article 101093"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147421645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Ocimum tenuiflorum (syn. Ocimum sanctum) as an adjunct in the management of gingivitis and periodontitis: a systematic review 缬草作为治疗牙龈炎和牙周炎的辅助药物的疗效：一项系统综述

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2026-03-01 Epub Date: 2026-02-19 DOI: 10.1016/j.hermed.2026.101094

Rajeswari Ravishankar , Lakshmi Sree Sankar , Kavitha Jayavel , Krishnan Viswanathan , Srinivasan Sivaprakasam , Divyapriya G. Kuppuswamy , Soundharyalakshmi Kumar

Background

Herbal adjuncts such as Ocimum tenuiflorum (Tulsi) have gained attention in periodontal therapy due to their anti-inflammatory, antimicrobial, and antioxidant properties, supporting their use in conjunction with conventional mechanical debridement.

Aim

This systematic review aimed to evaluate the clinical efficacy of Ocimum tenuiflorum as an adjunct in the management of gingivitis and periodontitis.

Methods

A comprehensive search of electronic databases and manual sources was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible randomised controlled trials (RCTs) involving Ocimum tenuiflorum in mouthrinse, gel, dentifrice, or local drug delivery formulations were included. Data on clinical parameters such as plaque index, gingival index, probing pocket depth, and clinical attachment level, as well as microbiological and biochemical markers, were extracted. Risk of bias was assessed using the RoB 2.0 tool.

Results

Thirteen RCTs involving varied formulations of Ocimum tenuiflorum (mouthwash, gel, dentifrice, nanofiber, and intrapocket delivery) were analysed. Across studies, Ocimum tenuiflorum demonstrated significant improvements in clinical parameters, often comparable to chlorhexidine and superior to placebo. Some studies also reported reductions in inflammatory markers and microbial load. Heterogeneity in study design, sample size, dosage, and follow-up duration was noted.

Conclusion

Within the limitations of existing evidence, Ocimum tenuiflorum appears to be an effective adjunctive agent in the management of gingivitis and periodontitis. However, further well-designed, multicentric RCTs with larger sample sizes and longer follow-up are required to establish standardised clinical protocols.

草药辅料，如芦花（Tulsi）因其抗炎、抗菌和抗氧化的特性而在牙周治疗中受到关注，支持其与传统机械清创联合使用。目的本系统综述旨在评价丁花菊辅助治疗牙龈炎和牙周炎的临床疗效。方法根据PRISMA （Preferred Reporting Items for Systematic Reviews and meta - analysis）指南，对电子数据库和手工资料进行全面检索。纳入了符合条件的随机对照试验（RCTs），其中包括漱口水、凝胶、牙膏或局部给药制剂中的天花菊。提取菌斑指数、牙龈指数、探诊袋深度、临床附着水平等临床参数，以及微生物和生化指标。使用RoB 2.0工具评估偏倚风险。结果对13项随机对照试验（rct）进行了分析，这些随机对照试验涉及不同剂型（漱口水、凝胶、牙膏、纳米纤维和胶囊内给药）。在所有的研究中，替努花在临床参数上表现出显著的改善，通常与氯己定相当，优于安慰剂。一些研究还报告了炎症标志物和微生物负荷的减少。注意到研究设计、样本量、剂量和随访时间的异质性。结论在现有证据的限制下，藤花是治疗牙龈炎和牙周炎的有效辅助药物。然而，需要进一步设计良好、样本量更大、随访时间更长的多中心随机对照试验来建立标准化的临床方案。

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引用次数: 0

Natural antiseptics versus chlorhexidine in the prevention of ventilator-associated pneumonia: a critical and qualitative review of clinical trials 天然防腐剂与氯己定预防呼吸机相关性肺炎：临床试验的关键和定性回顾

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2026-03-01 Epub Date: 2026-01-12 DOI: 10.1016/j.hermed.2026.101088

Paula Mariane Figueiredo, Maria Nazaré Lopes Baracho, Lívia Fialho Alcântara, Rodrigo Lellis Santos, Brender Leonan-Silva, Ana Clara Bernardes Barbosa, Amanda Neves Magalhães, Aline Moreira Cunha Monteiro, Olga Dumont Flecha

Introduction

Natural extract–based mouthwashes have been investigated as potential alternatives to chlorhexidine due to their lower toxicity, ability to reduce oral microbial load, and fewer reported side effects. This review aimed to assess their effectiveness compared with chlorhexidine in preventing ventilator-associated pneumonia in adult intensive care unit patients.

Methods

A qualitative critical review of clinical trials was conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) and Cochrane recommendations, with a registered protocol (PROSPERO: CRD420251043018). Searches were performed in five databases and the gray literature to identify trials comparing natural extract–based mouthwashes with chlorhexidine in mechanically ventilated adults. Four independent reviewers performed study selection, data extraction, and methodological appraisal using a CONSORT (Consolidated Standards of Reporting Trials)–based tool.

Results

Thirteen clinical trials met the inclusion criteria, all conducted in Iran between 2012 and 2024. Mouthwashes containing Zataria multiflora, chamomile, clove, or Ortodentol demonstrated effects that were generally comparable to those of chlorhexidine and were associated with fewer adverse reactions. However, variation in herbal formulations, sample sizes, and methodological quality, as well as the concentration of studies in a single geographic region, may limit the broader applicability of the findings.

Conclusion

Natural mouthwashes show promise as alternatives to chlorhexidine for reducing the risk of ventilator-associated pneumonia. Nevertheless, additional well-designed trials in diverse settings are required to confirm their clinical utility and improve the generalisability of available evidence.

基于天然提取物的漱口水被研究作为氯己定的潜在替代品，因为其毒性较低，能够减少口腔微生物负荷，并且报道的副作用较少。本综述旨在评估其与氯己定在预防成人重症监护病房患者呼吸机相关性肺炎方面的有效性。方法采用注册方案（PROSPERO: CRD420251043018），按照PRISMA（系统评价和荟萃分析首选报告项目）和Cochrane推荐对临床试验进行定性评价。在五个数据库和灰色文献中进行了检索，以确定在机械通气成人中比较天然提取物漱口水和氯己定的试验。四名独立审稿人使用基于CONSORT（综合报告试验标准）的工具进行研究选择、数据提取和方法学评价。结果13项临床试验符合纳入标准，均于2012年至2024年在伊朗进行。漱口水中含有扎连草、洋甘菊、丁香或牙齿醇，其效果通常与氯己定相当，而且不良反应较少。然而，草药配方、样本量和方法质量的差异，以及研究集中在单一地理区域，可能会限制研究结果的更广泛适用性。结论天然漱口水可替代氯己定降低呼吸机相关性肺炎的发生风险。然而，还需要在不同环境下进行更多设计良好的试验，以确认其临床效用并提高现有证据的普遍性。

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引用次数: 0

Traditional Algerian medicinal practices for treating gastrointestinal disorders: a systematic literature review 阿尔及利亚治疗胃肠疾病的传统医学实践：系统的文献综述

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2026-03-01 Epub Date: 2026-01-09 DOI: 10.1016/j.hermed.2026.101086

Hafsa Hamdaoui , Moulay Abderrahmane Malouki , Habiba Drici

Introduction

Gastrointestinal (GI) disorders are among the most common global health concerns, and existing pharmacological treatments are frequently associated with adverse side effects. In Algeria, local populations have long relied on medicinal plants to manage these disorders, reportedly without complications. However, researchers have not yet undertaken any systematic synthesis of this traditional knowledge.

Aim

This study presents the first systematic review of medicinal plants traditionally used in Algeria for the management of GI disorders to identify potential candidates for the development of safer, plant-based therapies.

Methods

We retrieved relevant ethnobotanical studies published between 2011 and 2024 from major scientific databases, including Science Direct, Springer Link, PubMed, Scopus, and Google Scholar. The search strategy employed predefined keywords and a selection process following the PRISMA 2020 guidelines.

Results and discussion

After screening and eligibility assessment, 92 studies were included. A total of 420 plant species belonging to 99 botanical families were identified as being traditionally used to treat GI disorders. The most frequently represented families were Asteraceae, Lamiaceae, Fabaceae, and Apiaceae. The review highlights the rich diversity of Algerian flora and the predominant role of these families in traditional digestive care.

Conclusion

This review provides a foundational ethnobotanical dataset that may guide future pharmacological and clinical research aimed at validating the efficacy and safety of Algerian medicinal plants for GI health. The findings underline the importance of preserving traditional knowledge while promoting evidence-based development of herbal therapeutics.

胃肠道疾病是全球最常见的健康问题之一，现有的药物治疗往往与不良副作用有关。在阿尔及利亚，当地居民长期依靠药用植物来治疗这些疾病，据报道没有并发症。然而，研究人员尚未对这一传统知识进行任何系统的综合。目的：本研究首次对阿尔及利亚传统上用于胃肠道疾病治疗的药用植物进行了系统综述，以确定开发更安全的植物性疗法的潜在候选药物。方法从Science Direct、施普林格Link、PubMed、Scopus和谷歌Scholar等主要科学数据库中检索2011 - 2024年间发表的相关民族植物学研究。搜索策略采用预定义的关键字和遵循PRISMA 2020指南的选择过程。经过筛选和合格性评估，纳入了92项研究。共鉴定出99个植物科的420种植物传统上用于治疗胃肠道疾病。最常见的科是菊科、紫堇科、豆科和蜂科。回顾强调了阿尔及利亚植物群的丰富多样性和这些家庭在传统消化保健中的主导作用。结论本综述提供了一个基础的民族植物学数据集，可以指导未来的药理学和临床研究，旨在验证阿尔及利亚药用植物对胃肠道健康的有效性和安全性。这些发现强调了在促进以证据为基础的草药疗法发展的同时保护传统知识的重要性。

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引用次数: 0

Effectiveness of aromatherapy using Rosa damascena oil on severity of premenstrual syndrome among Palestinian female students: randomised controlled clinical trial 玫瑰精油芳香疗法对巴勒斯坦女学生经前综合症严重程度的疗效：随机对照临床试验

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2026-03-01 Epub Date: 2026-01-09 DOI: 10.1016/j.hermed.2026.101087

Nuha Shawarb , Nedaa Brqawi , Rawan Moqadi , Zeina Badran , Areen Ma'moun Saleh Malak , Donia Halawan , Wasan abubaker , Hala Fahmawi , Manal Badrasawi

Background

Premenstrual syndrome (PMS) involves physical and psychological symptoms that can disrupt young women’s daily functioning, particularly among university students facing academic and social pressures. Aromatherapy has gained interest as a complementary approach for PMS management, yet evidence from controlled trials remains limited. This study examined the effectiveness of Rosa damascena aromatherapy on PMS and related psychological symptoms among Palestinian female university students.

Methods

A double-blind randomised controlled trial was conducted in two phases. Phase 1 used a cross-sectional survey to identify PMS prevalence and recruit participants with moderate-to-severe symptoms. In phase 2, participants were randomly assigned to inhale either Rosa damascena essential oil or an odourless placebo three times weekly for three months. Outcomes were assessed using validated self-reported tools, including the Depression, Anxiety, and Stress Scale (DASS-21), with adherence monitored throughout.

Results

Of 300 students screened, 107 met the criteria, and 69 were enrolled. They were randomised into the intervention (n = 35) or control group (n = 34). Baseline PMS and psychological scores were similar. Over time, PMS symptoms decreased significantly in both groups (intervention: −40%; control: −20%; P = 0.001). Depression (P = 0.006), anxiety (P = 0.002), and stress (P = 0.001) scores also declined. However, no significant between-group differences were found for PMS (P = 0.185), depression (P = 0.130), and anxiety (P = 0.150), while the stress score decreased similarly in both groups (P = 0.001).

Conclusion

Rosa damascena aromatherapy did not outperform placebo, although both groups showed meaningful improvement. Further studies are needed to clarify dosing and potential mechanisms.

经前综合症（PMS）涉及生理和心理症状，可扰乱年轻女性的日常功能，特别是在面临学术和社会压力的大学生中。芳香疗法作为经前症候群管理的补充方法已引起人们的兴趣，但来自对照试验的证据仍然有限。本研究探讨大马士革玫瑰芳香疗法对巴勒斯坦女大学生经前症候群及相关心理症状的疗效。方法采用双盲随机对照试验，分两期进行。第一阶段采用横断面调查来确定经前症候群的患病率，并招募有中重度症状的参与者。在第二阶段，参与者被随机分配吸入大马士革玫瑰精油或无气味安慰剂，每周三次，持续三个月。使用经过验证的自我报告工具评估结果，包括抑郁、焦虑和压力量表（DASS-21），并全程监测依从性。结果在筛选的300名学生中，符合标准的107名，被录取的69名。他们被随机分为干预组（n = 35）和对照组（n = 34）。基线经前症候群和心理评分相似。随着时间的推移，两组经前症候群症状均显著减轻（干预组：- 40%；对照组：- 20%；P = 0.001）。抑郁（P = 0.006）、焦虑（P = 0.002）、压力（P = 0.001）得分也有所下降。然而，经前综合症（P = 0.185）、抑郁（P = 0.130）和焦虑（P = 0.150）在两组间无显著差异，而应激评分在两组间下降相似（P = 0.001）。结论大马士革玫瑰芳香疗法并不优于安慰剂，尽管两组均有显著改善。需要进一步的研究来阐明剂量和潜在的机制。

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引用次数: 0

The effect of thyme oil on asthma symptoms and respiratory parameters in patients with asthma: a single-blind randomised controlled trial 百里香油对哮喘患者哮喘症状和呼吸参数的影响：一项单盲随机对照试验

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2026-03-01 Epub Date: 2026-01-21 DOI: 10.1016/j.hermed.2026.101090

Uğur Öner , Züleyha Gürdap , Zeliha Cengi̇z

Objective

This study aimed to evaluate the effectiveness of thyme oil inhalation as a complementary aromatherapy method in reducing asthma symptoms and improving respiratory function in hospitalised patients with asthma.

Materials and methods

A single-blind, placebo-controlled, pretest–posttest randomised controlled trial was conducted in the pulmonary ward of a tertiary hospital between 01 November 2024 and 20 May 2025. A total of 156 patients diagnosed with asthma were randomly assigned to three groups: intervention (n = 52), placebo (n = 52), and control (n = 52). The intervention group received thyme oil inhalation three times daily for four days. The placebo group received a neutral carrier oil inhalation, while the control group received routine care. Data were collected using standardised forms. Posttest evaluations were conducted on day four.

Results

After controlling for pretest scores, weight, and smoking habits using ANCOVA, the intervention group showed significant reductions in asthma symptoms, including dyspnoea, cough, nocturnal and chest wheezing, and secretion, compared with placebo and control groups (P < 0.05). Respiratory function, particularly forced expiratory volume in one second and forced expiratory volume in one second/forced vital capacity ratios, also improved.

Conclusion

Thyme oil inhalation appears to be an effective, safe, and nonpharmacological complementary therapy for asthma management. These findings suggest that thyme oil can significantly improve both clinical symptoms and respiratory function test results. It may be recommended as supportive care alongside standard asthma treatments. Further large-scale, long-term studies are necessary to establish optimal protocols and confirm these results.

Trial registration

The clinical trial was registered under the number NCT06664671. Registered on 28 October 2024, before patient enrolment began on 01 November 2024.

目的评价百里香油吸入作为一种辅助芳香疗法对哮喘住院患者减轻哮喘症状和改善呼吸功能的效果。材料与方法于2024年11月1日至2025年5月20日在某三级医院肺病房进行了一项单盲、安慰剂对照、前测后测随机对照试验。共有156名诊断为哮喘的患者被随机分为三组：干预组（n = 52）、安慰剂组（n = 52）和对照组（n = 52）。干预组每日吸入百里香油3次，连续4天。安慰剂组给予中性载体油吸入，对照组给予常规护理。数据采用标准化表格收集。第4天进行测试后评价。结果在使用ANCOVA控制测试前评分、体重和吸烟习惯后，干预组与安慰剂组和对照组相比，哮喘症状（包括呼吸困难、咳嗽、夜间和胸部喘息、分泌物）显著减少（P <； 0.05）。呼吸功能，特别是一秒钟用力呼气量和一秒钟用力呼气量/用力肺活量的比值也有所改善。结论百里香油吸入治疗哮喘是一种有效、安全的非药物辅助治疗方法。这些结果表明百里香油可以显著改善临床症状和呼吸功能测试结果。它可能被推荐作为标准哮喘治疗的辅助治疗。需要进一步的大规模长期研究来建立最佳方案并证实这些结果。试验注册本临床试验注册编号为NCT06664671。于2024年10月28日注册，在2024年11月1日开始患者登记之前。

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引用次数: 0

Herbal medicine in the first six months postpartum: a qualitative evidence synthesis of benefits, risks, and implementation challenges 产后前六个月的草药：益处、风险和实施挑战的定性证据综合

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2026-02-01 Epub Date: 2025-11-15 DOI: 10.1016/j.hermed.2025.101077

Qorinah Estiningtyas Sakilah Adnani , Nurul Azmi Aprianti , Nadya Fauzia Kusteja , Ela Nurfitriyani , Muhammad Alamsyah Aziz , Bibek Giri , Victor Abiola Adepoju

Background

Herbal medicine is widely used postpartum to aid recovery and lactation. Despite perceived benefits, safety and interaction concerns persist. Stronger evidence is needed to support its safe, culturally sensitive use.

Objective

To synthesise qualitative evidence on why and how postpartum women use herbal medicines and to identify reported benefits, risks, and implementation challenges.

Methods

We conducted a qualitative evidence synthesis using the GRADE-CERQual approach. Six databases (CINAHL, PubMed, PsycINFO, EMBASE, Health Source/Nursing Academic, Sage Complete) were searched for studies published to June 2025. Eligible studies explored herbal-medicine use among postpartum women and employed qualitative methods. Fifteen studies from 14 countries met the criteria.

Results

Herbal use in the first six weeks after birth is common but highly variable (reported prevalence 48%–97%) and deeply rooted in local traditions. Women most often cited perceived relief of pain, enhanced wound healing, and increased breastmilk production; frequently mentioned plants included ginger, turmeric, katuk, moringa, raspberry leaf, and chamomile. Decisions were shaped by elder advice, cost, and availability. Safety concerns centred on uncertain dosage, contamination, and potential interactions with prescribed uterotonics or antibiotics. Few studies reported guidance from trained health professionals, and regulatory oversight was minimal. Confidence in these findings ranged from high (motives and perceived benefits) to low (exact prevalence rates).

Conclusion

Postpartum women perceive clear advantages from herbal remedies, but qualitative evidence on clinical effectiveness and safety remains limited. Culturally sensitive counselling, routine enquiry about herb use, and pharmacovigilance systems are needed while more rigorous research clarifies benefits and risks.

产后广泛使用草药来帮助恢复和哺乳。尽管有明显的好处，但安全性和相互作用问题仍然存在。需要更有力的证据来支持其安全、具有文化敏感性的使用。目的综合产后妇女使用草药的原因和方式的定性证据，并确定报告的益处、风险和实施挑战。方法采用GRADE-CERQual方法进行定性证据综合。检索了六个数据库（CINAHL、PubMed、PsycINFO、EMBASE、Health Source/Nursing Academic、Sage Complete），检索了截至2025年6月发表的研究。合格的研究探讨了产后妇女使用草药的情况，并采用定性方法。来自14个国家的15项研究符合标准。结果在出生后的前6周使用保乳是常见的，但差异很大（报告患病率为48%-97%），并深深植根于当地传统。女性最常提到的是疼痛减轻，伤口愈合加快，母乳产量增加；经常提到的植物包括生姜、姜黄、木香、辣木、覆盆子叶和洋甘菊。决策是由长辈的建议、成本和可用性决定的。安全性问题集中在剂量不确定、污染以及与处方子宫强直剂或抗生素的潜在相互作用。很少有研究报告来自训练有素的卫生专业人员的指导，监管监督也很少。对这些发现的信心从高（动机和感知的利益）到低（确切的患病率）不等。结论产后妇女认识到草药治疗的明显优势，但临床有效性和安全性的定性证据仍然有限。在更严格的研究澄清益处和风险的同时，需要对文化敏感的咨询、对草药使用的常规询问和药物警戒系统。

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引用次数: 0