Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke

IF 1.3 Q4 CLINICAL NEUROLOGY Brain Hemorrhages Pub Date : 2024-10-01 DOI:10.1016/j.hest.2024.04.003

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Abstract

Stroke, characterized by sudden onset and significant mortality rates, represents a critical challenge in effectively treating neuroinflammation to improve treatment efficacy. In this context, mesenchymal stem cell (MSC)-derived exosomes have attracted significant attention in scientific research due to their diverse cellular origin, tiny size, and huge number of bioactive molecules. Recent studies have shed light on the remarkable potential of MSC-derived exosomes to not only suppress the inflammatory responses of microglia and astrocytes, but also enhance their neuroprotective functions. Moreover, these exosomes have demonstrated a remarkable ability to modulate various immune cells and inflammatory mediators, thereby exerting profound mitigating effects on neuroinflammation. Through a thorough examination of the role and underlying mechanisms of MSC-derived exosomes in mitigating neuroinflammation after stroke, this review aims to provide comprehensive information and recommendations for the development of innovative therapeutic strategies aimed at significantly improving the treatment of stroke.

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间充质干细胞衍生的外泌体对中风后炎症反应的影响

脑卒中具有发病突然、死亡率高的特点，是有效治疗神经炎症以提高疗效的重大挑战。在这种情况下，间充质干细胞（MSC）衍生的外泌体因其细胞来源多样、体积微小、含有大量生物活性分子而在科学研究中备受关注。最近的研究表明，间充质干细胞衍生的外泌体不仅具有抑制小胶质细胞和星形胶质细胞炎症反应的显著潜力，还能增强它们的神经保护功能。此外，这些外泌体还显示出调节各种免疫细胞和炎症介质的卓越能力，从而对神经炎症产生深远的缓解作用。本综述旨在通过深入研究间充质干细胞衍生的外泌体在缓解脑卒中后神经炎症中的作用及其内在机制，为开发创新治疗策略提供全面的信息和建议，从而显著改善脑卒中的治疗。

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