AN OBSERVATIONAL STUDY ON THE ASSOCIATION OF THYROID DYSFUNCTION WITH VITAMIN D DEFICIENCY IN THE FIRST TRIMESTER OF PREGNANT WOMEN SMS MEDICAL COLLEGE AND HOSPITAL JAIPUR RAJASTHAN

Abstract

Background-The deciency of vitamin D is known as a worldwide problem. Evidence has shown that vitamin D deciency may increase the risk of a wide range of chronic diseases. Also, its deciency can increase the likelihood of autoimmune diseases, upper respiratory tract infections, diabetes, cardiovascular disease, and cancer. Maternal thyroid function should be maintained normally, especially in the rst trimester. In the rst trimester, the fetus is fully dependent on maternal thyroid hormones for brain development After obtaining the necessary permission study was conducted in the Department of Bioche Methodology- mistry (Immunoassay lab) and Obstetrics and Gynecology SMS Medical College and Hospital, Jaipur This study includes 30 cases (vitamin D deciency in pregnant women in the rst trimester with 18-40yrs age group) and control (vitamin D sufcient women in the rst trimester with the age 18-40yrs age group) and difference in mean T3, T4and TSH level In this study, T4 levels (mean ± SD) were signican Result- tly higher in the vitamin D deciency group compared with the control group (9.89 vs. 53.0 ng/dl, P-value: <0.01), but there were no signicant differences between the 2 studies groups regarding TSH and free T3 levels. In Linear regression analysis, assessing the effects of vitamin D deciency plus maternal age, Body Mass Index, and number of pregnancies on thyroid function tests, it was shown that vitamin D deciency had only a signicant direct relation with free T4 levels (P-value: <0.01), but had no signicant relations with the other thyroid function tests namely TSH, and free T3 Conclusion-: A signicant direct relationships were observed between Vitamin D deciency with the level of thyroxin (T4) during the rst trimester of pregnancy. higher levels of T4 in vitamin D-decient mothers. Due to the negative effects of Vitamin D deciency and thyroid hormones on the mother, further studies should be conducted which may help in more accurate screening during pregnancy.