{"title":"A review on numerical studies of airflow dynamics and particle deposition in human respiratory system","authors":"Hao Jing, Xinguang Cui","doi":"10.1016/j.partic.2024.04.006","DOIUrl":null,"url":null,"abstract":"<div><p>Accurate assessment and prediction of airflow dynamics and particle deposition in the human respiratory tract are essential for human health, involving inhaled drugs for treating various diseases and toxic particles that can cause illnesses. This intricate process involves complex multiphase flow with distinct respiratory characteristics. Computational fluid dynamics (CFD) acts as a bridge, overcoming the limitations of in vivo and in vitro experiments and providing a means to fully comprehend and reveal the fundamental mechanisms of respiratory flow and particle behavior on a microscopic scale. This paper provides a comprehensive overview and concise summary of recent advancements in the numerical simulation of airflow and particle deposition in the human respiratory tract. Particularly, it summarizes the transition of respiratory tract models from segmented models to emerging physiological characteristic models and whole-lung airway models, and the latest developments on the effects of key factors such as geometric variations, respiratory patterns, and particle physical/chemical properties on respiratory flow and particle deposition. A notable focus of this review is on emerging physiological characteristics models and their associated complex airflow and particle dynamics inside it. The paper concludes with recommendations for future research to further advance the development of this field.</p></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Particuology","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1674200124000609","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Accurate assessment and prediction of airflow dynamics and particle deposition in the human respiratory tract are essential for human health, involving inhaled drugs for treating various diseases and toxic particles that can cause illnesses. This intricate process involves complex multiphase flow with distinct respiratory characteristics. Computational fluid dynamics (CFD) acts as a bridge, overcoming the limitations of in vivo and in vitro experiments and providing a means to fully comprehend and reveal the fundamental mechanisms of respiratory flow and particle behavior on a microscopic scale. This paper provides a comprehensive overview and concise summary of recent advancements in the numerical simulation of airflow and particle deposition in the human respiratory tract. Particularly, it summarizes the transition of respiratory tract models from segmented models to emerging physiological characteristic models and whole-lung airway models, and the latest developments on the effects of key factors such as geometric variations, respiratory patterns, and particle physical/chemical properties on respiratory flow and particle deposition. A notable focus of this review is on emerging physiological characteristics models and their associated complex airflow and particle dynamics inside it. The paper concludes with recommendations for future research to further advance the development of this field.
期刊介绍:
The word ‘particuology’ was coined to parallel the discipline for the science and technology of particles.
Particuology is an interdisciplinary journal that publishes frontier research articles and critical reviews on the discovery, formulation and engineering of particulate materials, processes and systems. It especially welcomes contributions utilising advanced theoretical, modelling and measurement methods to enable the discovery and creation of new particulate materials, and the manufacturing of functional particulate-based products, such as sensors.
Papers are handled by Thematic Editors who oversee contributions from specific subject fields. These fields are classified into: Particle Synthesis and Modification; Particle Characterization and Measurement; Granular Systems and Bulk Solids Technology; Fluidization and Particle-Fluid Systems; Aerosols; and Applications of Particle Technology.
Key topics concerning the creation and processing of particulates include:
-Modelling and simulation of particle formation, collective behaviour of particles and systems for particle production over a broad spectrum of length scales
-Mining of experimental data for particle synthesis and surface properties to facilitate the creation of new materials and processes
-Particle design and preparation including controlled response and sensing functionalities in formation, delivery systems and biological systems, etc.
-Experimental and computational methods for visualization and analysis of particulate system.
These topics are broadly relevant to the production of materials, pharmaceuticals and food, and to the conversion of energy resources to fuels and protection of the environment.