Oil-extracted from flaxseeds protects against endothelial dysfunction and oxidative stress by modulating nitric oxide, thiols contents and improving redox status in ouabain-induced hypertensive rats

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Nutrition Clinique et Metabolisme Pub Date : 2024-04-10 DOI:10.1016/j.nupar.2024.02.003

Sadia Berzou , Fatima Zohra Labbaci , Akila Guenzet , Nawal Dida-Taleb , Hakima Mir , Djamil Krouf

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Abstract

Objectives

The purpose of this study was to evaluate the antihypertensive and antioxidant effects of flaxseed oil in ouabain-induced hypertensive in normal rats Wistar.

Methods

Experimental hypertension was induced by a daily subcutaneous (sc) injection of 10 μg/kg/day/rat of ouabain diluted in 9 g/L of saline solution (NaCl) for 21 days (n = 16). Animals were then divided into two groups fed an experimental diet containing 20% casein supplemented (Ouab-Oil-Lu) or not (Ouab) with 1% flaxseed oil whereas control rats (n = 8) received only a daily sc injection of NaCl.

Results

The results showed that supplementing hypertensive rats with 1% flaxseed oil decreased significantly (P < 0.05) the systolic, diastolic, and mean arterial pressure, ameliorated plasma and liver lipid profile and reduced glucose levels in plasma. Similarly, flaxseed oil decreased TBARS levels in plasma and tissues, as well as carbonyl levels in the heart. Interestingly, this supplementation increased GSH, thiols and nitric oxide levels and improved AchE and antioxidant enzyme activities (SOD and GSH-Px) in the tissues.

Conclusions

Our findings suggested that flaxseed oil may provide a rationale for antihypertensive use in traditional medicine.

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亚麻籽萃取油通过调节一氧化氮、硫醇含量和改善氧化还原状态，保护乌巴因诱导的高血压大鼠免受内皮功能障碍和氧化应激的影响

本研究的目的是评估亚麻籽油对乌巴因诱导的正常 Wistar 大鼠高血压的降压和抗氧化作用。方法通过每天皮下注射 10 μg/kg/ 天/只大鼠的乌巴因（稀释在 9 g/L 的生理盐水（NaCl）中）来诱导实验性高血压，连续 21 天（n = 16）。结果结果表明，给高血压大鼠补充 1%的亚麻籽油能显著降低收缩压、舒张压和平均动脉压（P < 0.05），改善血浆和肝脏脂质状况，降低血浆中的葡萄糖水平。同样，亚麻籽油降低了血浆和组织中的 TBARS 水平以及心脏中的羰基水平。有趣的是，补充亚麻籽油能增加 GSH、硫醇和一氧化氮水平，改善组织中的 AchE 和抗氧化酶活性（SOD 和 GSH-Px）。

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来源期刊

Nutrition Clinique et Metabolisme 医学-内分泌学与代谢

CiteScore

0.80

自引率

16.70%

发文量

216

审稿时长

78 days

期刊介绍： Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.