Nutrition Clinique et Metabolisme最新文献

{"title":"Mapping food and nutrition literacy in non-communicable disease contexts: A scoping review","authors":"Omer Qutaiba B. Allela ,&nbsp;Abdulkareem Shareef ,&nbsp;Hayder Naji Sameer ,&nbsp;Ahmed Yaseen ,&nbsp;Zainab H. Athab ,&nbsp;Mohaned Adil","doi":"10.1016/j.nupar.2026.103031","DOIUrl":"10.1016/j.nupar.2026.103031","url":null,"abstract":"<div><h3>Objectives</h3><div>Food and nutrition literacy (FNL), the ability to access, understand, evaluate, and apply nutrition information, is increasingly recognized as a critical determinant of dietary behavior and chronic disease outcomes. This scoping review aimed to synthesize global evidence on the prevalence, measurement approaches, and clinical and behavioral correlates of FNL among adults living with non-communicable diseases (NCDs), and to clarify its relevance for clinical care and public health practice.</div></div><div><h3>Material and methods</h3><div>Following the PRISMA-ScR guidelines, PubMed, Scopus, Web of Science, and Google Scholar were systematically searched for peer-reviewed studies up to October 30, 2025. Eligible studies assessed functional, interactive, or critical FNL in adults with NCDs. Data were extracted on study characteristics, FNL measurement, and associations with behavioral or clinical outcomes. Two researchers independently performed searches of electronic databases, study selection, and data extraction, with discrepancies resolved by consensus or a third reviewer.</div></div><div><h3>Results</h3><div>Thirteen studies, covering 5004 participants across diverse settings, were included. FNL levels were generally suboptimal, with pronounced deficits in label interpretation, portion control, meal planning, and critical appraisal. Higher FNL was consistently associated with healthier dietary behaviors, improved self-management, and better cardiometabolic indicators. Functional literacy supported adherence to evidence-based diets, while interactive and critical literacy enhanced patient-provider communication and resilience against misleading nutrition information.</div></div><div><h3>Conclusion</h3><div>FNL is a modifiable, clinically actionable determinant of chronic disease management. Integrating FNL assessment and education into care pathways can empower patients, strengthen long-term adherence, and support population-level NCD prevention.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 2","pages":"Article 103031"},"PeriodicalIF":0.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating inflammation and nutrition: A multi-visual meta-analysis of serum biomarkers and COVID-19 severity","authors":"Nayebali Ahmadi ,&nbsp;Maryam Shahali ,&nbsp;Mohammad Javad Hossein Tehrani ,&nbsp;Danial Sarlak ,&nbsp;Rajab Mardani","doi":"10.1016/j.nupar.2026.103034","DOIUrl":"10.1016/j.nupar.2026.103034","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic has revealed substantial heterogeneity in biomarker profiles associated with disease severity. While inflammation-driven responses are implicated in progression to critical illness, the role of nutritional status and micronutrient levels in shaping outcomes remains incompletely understood. This study integrates 35 studies using a multi-visual meta-analytic approach to delineate the relationships between inflammatory biomarkers, nutritional/vitamin markers, and severe COVID-19 outcomes.</div></div><div><h3>Methods</h3><div>We conducted a systematic search of major databases (PubMed/MEDLINE, Embase, and Web of Science) for studies reporting quantitative associations between serum biomarkers and COVID-19 severity or mortality. Data were harmonized to standardized mean differences (SMDs) where possible. A multi-plot synthesis (forest, funnel, volcano, and bubble plots) was employed to capture effect sizes, precision, heterogeneity, publication bias, and variance. Inclusion criteria encompassed adult participants with confirmed SARS-CoV-2 infection who reported inflammatory markers (CRP, IL-6, ferritin), nutritional markers (e.g., albumin, pre-albumin), vitamins (e.g., A, C, D, E), and immune markers, where available. Exclusion criteria included pediatric populations and studies lacking extractable quantitative data.</div></div><div><h3>Results</h3><div>Across 35 studies, inflammatory biomarkers were consistently elevated in severe COVID-19, with CRP, IL-6, and ferritin showing directionally positive associations with adverse outcomes. Nutritional and micronutrient markers tended to be reduced in severe cases, with albumin and several vitamins (notably vitamin D, C, and E) frequently depleted, though substantial between-study heterogeneity existed. The integrated visualizations revealed concordant signals of inflammation amid variable nutritional statuses, while funnel plots suggested modest small-study effects that did not materially alter the overall conclusions. Sensitivity analyses confirmed robustness of the main inflammation-associated findings and highlighted context-dependent variability for nutritional markers. Collectively, the results underscore a central inflammatory axis in severe COVID-19, modulated by nutritional and micronutrient status, with implications for risk stratification and supportive care strategies.</div></div><div><h3>Conclusions</h3><div>Our multi-plot synthesis provides a cohesive narrative linking systemic inflammation with adverse outcomes in COVID-19 and delineates nuanced roles for nutritional and vitamin-related factors. These findings support concurrent emphasis on anti-inflammatory management and nutritional optimization in high-risk patients, while also guiding future research to disentangle context-specific moderators and to test targeted nutritional interventions.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 2","pages":"Article 103034"},"PeriodicalIF":0.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the brain-gut-taste axis: The role of GLP-1-mediated SGLT-1 signaling in metabolic diseases","authors":"Yang Heng ,&nbsp;Yang Qiuming","doi":"10.1016/j.nupar.2026.103032","DOIUrl":"10.1016/j.nupar.2026.103032","url":null,"abstract":"<div><div>The global pandemic of metabolic diseases, such as obesity and type 2 diabetes, underscores an urgent need for innovative therapeutic strategies. Emerging evidence has established the intestine as a central player in nutrient sensing and systemic metabolic regulation. This review systematically delineates the critical role of the sodium-glucose cotransporter 1 (SGLT-1) in metabolic control and elaborates on the molecular mechanisms through which glucagon-like peptide-1 (GLP-1) modulates metabolic homeostasis via the brain-gut-taste axis. By reviewing and integrating recent evidence, we propose a novel paradigm wherein GLP-1, through the modulation of intestinal SGLT-1 signaling, influences taste perception and food preferences, thereby orchestrating systemic metabolic outcomes. This mechanism provides a compelling rationale for developing therapies that would target the gut-brain axis, representing a potential breakthrough in managing metabolic disorders. Finally, we outline current limitations and future challenges in translating these insights into clinical practice, to propose a framework for guiding research in this promising field.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 2","pages":"Article 103032"},"PeriodicalIF":0.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between dietary fiber consumption and chronic obstructive pulmonary disease: A systematic review and meta-analysis","authors":"Qiang Lu ,&nbsp;Lei Zhang ,&nbsp;Yan Wang ,&nbsp;Huaiyu Hao","doi":"10.1016/j.nupar.2025.103029","DOIUrl":"10.1016/j.nupar.2025.103029","url":null,"abstract":"<div><h3>Objective</h3><div>This study with a systematic review and meta-analysis design aimed to specially investigate the relationship between dietary fiber intake and chronic obstructive pulmonary disease.</div></div><div><h3>Materials and methods</h3><div>A search was performed in the databases of Web of Science, PubMed, and Scopus. The articles retrieved from these databases were carefully reviewed and screened by the research team. Ultimately, articles that met the established inclusion and exclusion criteria were selected for data extraction. The quality of these studies was evaluated using the Joanna Briggs Institute (JBI) critical appraisal instruments. To integrate the findings, a meta-analysis was performed to aggregate the reported odds ratios and hazard ratios from the chosen studies.</div></div><div><h3>Results</h3><div>Fifteen studies were entered into the review. Thirteen of 15 reviewed papers (86.7 percent) revealed that there is an association between dietary fiber intake and risk of COPD. The values of the odds ratio and hazard ratio related to the impact of fiber consumption on the decreased risk of COPD were between 0.46 to 0.98 and 0.54 to 0.70. The results of meta-analysis showed that fiber intake can decrease the risk of COPD [odd ratio: 0.866 (95% CI: 0.773–0.971); <em>P</em> <!-->=<!--> <!-->0.014; I² <!-->=<!--> <!-->79.30 and hazard ratio: 0.636 (95% CI: 0.538–0.751); <em>P</em> <!-->&lt;<!--> <!-->0.001; I² <!-->=<!--> <!-->41.29].</div></div><div><h3>Conclusion</h3><div>The results showed that fiber intake can significantly reduce the risk of COPD. Hence, it is suggested that dietary plans on fiber intake are implemented, especially in poor countries.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 2","pages":"Article 103029"},"PeriodicalIF":0.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atteintes hépatiques en lien avec la dénutrition dans l’anorexie mentale – Revue de la littérature","authors":"Jade Deglaire,&nbsp;Thomas Mouillot","doi":"10.1016/j.nupar.2025.103028","DOIUrl":"10.1016/j.nupar.2025.103028","url":null,"abstract":"<div><div>Malnutrition – particularly in anorexia nervosa – can have significant hepatic repercussions. As the central organ of metabolism, the liver is particularly vulnerable to nutritional disturbances. Two principal forms of hepatitis related to malnutrition have been described in the literature: starvation hepatitis and refeeding-induced hepatitis. The former mainly results from excessive hepatocellular autophagy and hypoxia due to dehydration and hypovolemia, and is usually associated with clinical symptoms. In contrast, the latter is frequently linked to inappropriate refeeding syndrome, is clinically asymptomatic, and occurs during overly rapid or calorie-dense refeeding, leading to hepatic steatosis. This article is based on an international literature review highlighting diagnostic criteria, pathophysiological mechanisms (autophagy, hypoxia, steatosis), specific risks, and therapeutic management of liver diseases associated with malnutrition in the context of anorexia nervosa.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 2","pages":"Article 103028"},"PeriodicalIF":0.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146006588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact de l’augmentation du temps diététique sur le dépistage et la valorisation médicoéconomique de la dénutrition en chirurgie orthopédique","authors":"Vérane Peyratout Gueho ,&nbsp;Simon Atmeare ,&nbsp;Clarysse Addario ,&nbsp;Marine Tourscher ,&nbsp;Emilie Racano","doi":"10.1016/j.nupar.2026.103030","DOIUrl":"10.1016/j.nupar.2026.103030","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of increasing dietitian presence in an orthopedic surgery department on malnutrition screening and the associated healthcare revenue.</div></div><div><h3>Methods</h3><div>A retrospective observational study was conducted in the orthopedic surgery department of a hospital over two consecutive periods (January and February 2023). The allocated dietitian time was increased from 10 to 50%. Data collected included the number of patients hospitalized for more than 48<!--> <!-->hours, dietitian consultations, malnutrition diagnoses, upgraded Diagnosis-Related Group (DRG) classifications, and the corresponding financial valuation.</div></div><div><h3>Results</h3><div>The increase in dietitian time led to a significant rise in dietetic consultations (15.2 vs. 83.8%; <em>P</em> <!-->&lt;<!--> <!-->0.001), malnutrition diagnoses (7 vs. 26; <em>P</em> <!-->=<!--> <!-->0.0039), and upgraded hospital stays (5 vs. 15). Monthly financial valuation quadrupled from €9,517 to €41,801. The malnutrition coding rate in the department increased from 6.7 to 18.3%, while it remained stable at the institutional level.</div></div><div><h3>Conclusion</h3><div>Enhancing dietitian presence significantly improved malnutrition screening and coding, with substantial financial impact. This reorganization highlights the value of increasing human resources dedicated to hospital nutrition. It contributes to improved quality of care and resource optimization, aligning with the objectives of the French National Nutrition and Health Program (PNNS).</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 2","pages":"Article 103030"},"PeriodicalIF":0.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L’éditorial du président de la SNFCM","authors":"Didier Quilliot","doi":"10.1016/j.nupar.2026.103035","DOIUrl":"10.1016/j.nupar.2026.103035","url":null,"abstract":"","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103035"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147396493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between coffee consumption and diarrhea: A cross-sectional study based on NHANES data","authors":"Xiaoyang Zhang ,&nbsp;Xiaomin Lin ,&nbsp;Yahui Sun ,&nbsp;Qingfeng Zeng ,&nbsp;Yurong Liang ,&nbsp;Wenfei Zha ,&nbsp;Na Mi ,&nbsp;Weijie Gu","doi":"10.1016/j.nupar.2025.11.004","DOIUrl":"10.1016/j.nupar.2025.11.004","url":null,"abstract":"<div><h3>Background</h3><div>Coffee, one of the most globally consumed beverages with annual trade volumes exceeding $10<!--> <!-->billion USD, has been epidemiologically associated with gastrointestinal effects due to its bioactive constituents, particularly caffeine. While previous studies have suggested potential impacts of coffee consumption on digestive physiology, the precise mechanisms and dose-response relationships remain poorly characterized. This cross-sectional investigation utilizes nationally representative data from the National Health and Nutrition Examination Survey (NHANES) to systematically examine the association between coffee intake patterns and diarrheal incidence in the U.S. adult population.</div></div><div><h3>Methods</h3><div>This study conducted a cross-sectional analysis of self-reported diarrhea and coffee intake from the 2005–2020 National Health and Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression models and restricted cubic splines (RCS) were employed to assess the association between coffee consumption and diarrhea, with results presented as odds ratios (ORs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>In this observational study, a total of 9544 eligible participants were included. After adjusting for potential confounding variables, higher coffee consumption was associated with an increased risk of diarrhea compared to lower coffee consumption, regardless of whether intake was measured in grams (<em>P</em> overall<!--> <!-->=<!--> <!-->0.01) or cups (<em>P</em> overall<!--> <!-->=<!--> <!-->0.04). Furthermore, a restricted cubic spline (RCS) analysis revealed a statistically significant linear positive correlation between coffee intake and diarrhea risk (<em>P</em> for nonlinearity<!--> <!-->&lt;<!--> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>This population-based study demonstrates a statistically significant association between coffee intake and the incidence of diarrhea, regardless of whether consumption is measured in grams or cups. Therefore, individuals prone to gastrointestinal discomfort may benefit from moderating their coffee intake to reduce the risk of diarrhea.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103020"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of vitamin D supplementation on COVID-19 mortality: A systematic review and meta-analysis","authors":"Azam Doustmohammadian ,&nbsp;Maryam Amini ,&nbsp;Bahareh Nikooyeh ,&nbsp;Maryam Hajigholam-Saryazdi ,&nbsp;Sepideh Alibeyk ,&nbsp;Melika Hajjar","doi":"10.1016/j.nupar.2025.12.001","DOIUrl":"10.1016/j.nupar.2025.12.001","url":null,"abstract":"<div><h3>Background and aims</h3><div>This study aimed to synthesize available evidence on the impact of vitamin D supplementation on COVID-19-related mortality through a systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>We systematically searched major databases for randomized controlled trials (RCTs), quasi-RCTs, and cluster-randomized trials published between October 1, 2019, and December 14, 2024, evaluating vitamin D supplementation in adult patients with laboratory-confirmed COVID-19. Studies were included if they reported mortality outcomes and compared vitamin D with placebo, standard care, or no intervention. Risk of bias was assessed using the Cochrane tool. Pooled odds ratios (ORs) were calculated using a random-effects model. Subgroup analyses were performed by age and sex composition. Publication bias was assessed via funnel plot symmetry and Egger's test.</div></div><div><h3>Results</h3><div>A total of 24 studies encompassing diverse populations across hospital, ICU, and community settings were included. Sample sizes ranged from 32 to 6200 participants, and intervention durations from 5 to 180<!--> <!-->days. A pooled analysis revealed that vitamin D supplementation was associated with a significant 33% reduction in COVID-19 mortality (OR<!--> <!-->=<!--> <!-->0.67; 95% CI: 0.46–0.98; <em>P</em> <!-->=<!--> <!-->0.04), with moderate heterogeneity (I² <!-->=<!--> <!-->48.2%). Subgroup analysis revealed a greater benefit among patients aged 65<!--> <!-->years or older (minimal heterogeneity; I² <!-->=<!--> <!-->4.3%) and among studies with more than 50% female participants (OR<!--> <!-->=<!--> <!-->0.47; <em>P</em> <!-->=<!--> <!-->0.01). No significant publication bias was detected.</div></div><div><h3>Conclusions</h3><div>Vitamin D may confer a protective effect against COVID-19 mortality, particularly among older adults and women. It represents a promising adjunctive strategy in COVID-19 management.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103022"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145841512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic esophagitis; An updated review","authors":"Mohamed Guda ,&nbsp;Aseel Almagrabi ,&nbsp;Muhammed Zahri ,&nbsp;Nada A. Alshaikh ,&nbsp;Elsayed Ghoneem","doi":"10.1016/j.nupar.2025.12.002","DOIUrl":"10.1016/j.nupar.2025.12.002","url":null,"abstract":"<div><div>Chronic inflammatory esophageal illness, also known as eosinophilic esophagitis (EoE), is mostly caused by immunological responses mediated by T-helper 2 (Th2) cells. Dysphagia, chest pain, and regurgitation are some of the symptoms that can be seen in both adults and children. Specific histological criteria usually lead to a diagnosis of the condition, which is marked by eosinophilic infiltration of the esophagus. It is more common in men, and the incidence and prevalence of EoE are on the rise, especially in high-income nations. The etiology of EoE is influenced by both hereditary and environmental factors. In order to manage EoE effectively, it is necessary to deal with the inflammatory and fibrostenotic components of the condition simultaneously. Efficacious dietary elimination programs, such as the 6-food elimination diet (6FED), are currently being used as therapies, along with proton pump inhibitors (PPIs) and topical corticosteroids. Dupilumab and other monoclonal antibodies that target the interleukin-4 receptor alpha are examples of biologic therapeutics that are showing promise as treatments, especially for patients who have not responded to conventional methods. Nevertheless, studies are still being conducted to determine the medicines’ long-term safety and effectiveness in various patient populations.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103023"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}