Nutrition Clinique et Metabolisme最新文献

Mapping food and nutrition literacy in non-communicable disease contexts: A scoping review 在非传染性疾病背景下绘制食物和营养知识图谱：范围审查

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2026-01-30 DOI: 10.1016/j.nupar.2026.103031

Omer Qutaiba B. Allela , Abdulkareem Shareef , Hayder Naji Sameer , Ahmed Yaseen , Zainab H. Athab , Mohaned Adil

Objectives

Food and nutrition literacy (FNL), the ability to access, understand, evaluate, and apply nutrition information, is increasingly recognized as a critical determinant of dietary behavior and chronic disease outcomes. This scoping review aimed to synthesize global evidence on the prevalence, measurement approaches, and clinical and behavioral correlates of FNL among adults living with non-communicable diseases (NCDs), and to clarify its relevance for clinical care and public health practice.

Material and methods

Following the PRISMA-ScR guidelines, PubMed, Scopus, Web of Science, and Google Scholar were systematically searched for peer-reviewed studies up to October 30, 2025. Eligible studies assessed functional, interactive, or critical FNL in adults with NCDs. Data were extracted on study characteristics, FNL measurement, and associations with behavioral or clinical outcomes. Two researchers independently performed searches of electronic databases, study selection, and data extraction, with discrepancies resolved by consensus or a third reviewer.

Results

Thirteen studies, covering 5004 participants across diverse settings, were included. FNL levels were generally suboptimal, with pronounced deficits in label interpretation, portion control, meal planning, and critical appraisal. Higher FNL was consistently associated with healthier dietary behaviors, improved self-management, and better cardiometabolic indicators. Functional literacy supported adherence to evidence-based diets, while interactive and critical literacy enhanced patient-provider communication and resilience against misleading nutrition information.

Conclusion

FNL is a modifiable, clinically actionable determinant of chronic disease management. Integrating FNL assessment and education into care pathways can empower patients, strengthen long-term adherence, and support population-level NCD prevention.

食品和营养素养（FNL），即获取、理解、评估和应用营养信息的能力，越来越被认为是饮食行为和慢性疾病结局的关键决定因素。本综述旨在综合全球非传染性疾病（NCDs）成人中FNL患病率、测量方法以及临床和行为相关性的证据，并阐明其与临床护理和公共卫生实践的相关性。材料和方法按照PRISMA-ScR指南，系统检索PubMed、Scopus、Web of Science和b谷歌Scholar，检索截止到2025年10月30日的同行评议研究。符合条件的研究评估了非传染性疾病成人的功能性、互动性或关键性FNL。提取有关研究特征、FNL测量以及与行为或临床结果的关联的数据。两名研究人员独立进行电子数据库搜索、研究选择和数据提取，差异由共识或第三方审稿人解决。结果纳入13项研究，涵盖5004名不同环境的参与者。FNL水平通常是次优的，在标签解释、份量控制、膳食计划和批判性评价方面存在明显缺陷。较高的FNL始终与更健康的饮食行为、改善的自我管理和更好的心脏代谢指标相关。功能性读写能力支持对循证饮食的坚持，而互动性和批判性读写能力增强了患者与提供者之间的沟通和抵御误导性营养信息的能力。结论fnl是一种可改变的、临床可操作的慢性疾病治疗决定因素。将FNL评估和教育纳入护理途径可以增强患者的权能，加强长期依从性，并支持人群层面的非传染性疾病预防。

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引用次数: 0

Impact de l’augmentation du temps diététique sur le dépistage et la valorisation médicoéconomique de la dénutrition en chirurgie orthopédique 饮食时间的增加对骨科手术中营养不良的筛查和医学经济价值的影响

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2026-01-29 DOI: 10.1016/j.nupar.2026.103030

Vérane Peyratout Gueho , Simon Atmeare , Clarysse Addario , Marine Tourscher , Emilie Racano

Objective

To evaluate the impact of increasing dietitian presence in an orthopedic surgery department on malnutrition screening and the associated healthcare revenue.

Methods

A retrospective observational study was conducted in the orthopedic surgery department of a hospital over two consecutive periods (January and February 2023). The allocated dietitian time was increased from 10 to 50%. Data collected included the number of patients hospitalized for more than 48 hours, dietitian consultations, malnutrition diagnoses, upgraded Diagnosis-Related Group (DRG) classifications, and the corresponding financial valuation.

Results

The increase in dietitian time led to a significant rise in dietetic consultations (15.2 vs. 83.8%; P < 0.001), malnutrition diagnoses (7 vs. 26; P = 0.0039), and upgraded hospital stays (5 vs. 15). Monthly financial valuation quadrupled from €9,517 to €41,801. The malnutrition coding rate in the department increased from 6.7 to 18.3%, while it remained stable at the institutional level.

Conclusion

Enhancing dietitian presence significantly improved malnutrition screening and coding, with substantial financial impact. This reorganization highlights the value of increasing human resources dedicated to hospital nutrition. It contributes to improved quality of care and resource optimization, aligning with the objectives of the French National Nutrition and Health Program (PNNS).

目的评价骨科增加营养师对营养不良筛查及相关医疗收入的影响。方法于2023年1月和2月连续两期在某医院骨科进行回顾性观察研究。分配给营养师的时间从10%增加到50%。收集的数据包括住院超过48小时的患者人数、营养师咨询、营养不良诊断、升级的诊断相关组（DRG）分类以及相应的财务评估。结果营养师时间的增加导致饮食咨询（15.2 vs. 83.8%; P < 0.001）、营养不良诊断（7 vs. 26; P = 0.0039）和住院时间（5 vs. 15）显著增加。每月财务估值翻了两番，从9517欧元增至41801欧元。该科的营养不良编码率从6.7上升到18.3%，而在机构层面保持稳定。结论增加营养学家的存在可显著改善营养不良筛查和编码，并具有显著的经济效益。这一重组凸显了增加专门用于医院营养的人力资源的价值。它有助于提高护理质量和优化资源，符合法国国家营养和健康方案的目标。

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引用次数: 0

The association between dietary fiber consumption and chronic obstructive pulmonary disease: A systematic review and meta-analysis 膳食纤维摄入与慢性阻塞性肺疾病之间的关系：一项系统综述和荟萃分析

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2026-01-23 DOI: 10.1016/j.nupar.2025.103029

Qiang Lu , Lei Zhang , Yan Wang , Huaiyu Hao

Objective

This study with a systematic review and meta-analysis design aimed to specially investigate the relationship between dietary fiber intake and chronic obstructive pulmonary disease.

Materials and methods

A search was performed in the databases of Web of Science, PubMed, and Scopus. The articles retrieved from these databases were carefully reviewed and screened by the research team. Ultimately, articles that met the established inclusion and exclusion criteria were selected for data extraction. The quality of these studies was evaluated using the Joanna Briggs Institute (JBI) critical appraisal instruments. To integrate the findings, a meta-analysis was performed to aggregate the reported odds ratios and hazard ratios from the chosen studies.

Results

Fifteen studies were entered into the review. Thirteen of 15 reviewed papers (86.7 percent) revealed that there is an association between dietary fiber intake and risk of COPD. The values of the odds ratio and hazard ratio related to the impact of fiber consumption on the decreased risk of COPD were between 0.46 to 0.98 and 0.54 to 0.70. The results of meta-analysis showed that fiber intake can decrease the risk of COPD [odd ratio: 0.866 (95% CI: 0.773–0.971); P = 0.014; I² = 79.30 and hazard ratio: 0.636 (95% CI: 0.538–0.751); P < 0.001; I² = 41.29].

Conclusion

The results showed that fiber intake can significantly reduce the risk of COPD. Hence, it is suggested that dietary plans on fiber intake are implemented, especially in poor countries.

目的本研究采用系统评价和荟萃分析设计，专门探讨膳食纤维摄入与慢性阻塞性肺疾病的关系。材料与方法在Web of Science、PubMed、Scopus数据库中进行检索。研究小组对从这些数据库中检索到的文章进行了仔细的审查和筛选。最终，选择符合既定纳入和排除标准的文章进行数据提取。这些研究的质量使用乔安娜布里格斯研究所（JBI）的关键评估工具进行评估。为了整合这些发现，我们进行了荟萃分析，汇总了所选研究报告的优势比和风险比。结果共纳入15项研究。15篇综述论文中有13篇（86.7%）显示膳食纤维摄入量与慢性阻塞性肺病风险之间存在关联。与纤维摄入对COPD风险降低的影响相关的比值比和风险比分别在0.46 ~ 0.98和0.54 ~ 0.70之间。荟萃分析结果显示，纤维摄入可降低COPD风险[奇比：0.866 (95% CI: 0.773-0.971)；p = 0.014；I2 = 79.30，风险比：0.636 (95% CI: 0.538 ~ 0.751)；P < 0.001；[2 = 41.29]。结论膳食纤维摄入可显著降低COPD发病风险。因此，建议实施膳食纤维摄入计划，特别是在贫穷国家。

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引用次数: 0

Atteintes hépatiques en lien avec la dénutrition dans l’anorexie mentale – Revue de la littérature 营养不良对厌食症肝脏的影响-文献综述

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2026-01-21 DOI: 10.1016/j.nupar.2025.103028

Jade Deglaire, Thomas Mouillot

Malnutrition – particularly in anorexia nervosa – can have significant hepatic repercussions. As the central organ of metabolism, the liver is particularly vulnerable to nutritional disturbances. Two principal forms of hepatitis related to malnutrition have been described in the literature: starvation hepatitis and refeeding-induced hepatitis. The former mainly results from excessive hepatocellular autophagy and hypoxia due to dehydration and hypovolemia, and is usually associated with clinical symptoms. In contrast, the latter is frequently linked to inappropriate refeeding syndrome, is clinically asymptomatic, and occurs during overly rapid or calorie-dense refeeding, leading to hepatic steatosis. This article is based on an international literature review highlighting diagnostic criteria, pathophysiological mechanisms (autophagy, hypoxia, steatosis), specific risks, and therapeutic management of liver diseases associated with malnutrition in the context of anorexia nervosa.

营养不良——尤其是神经性厌食症——会对肝脏造成严重影响。肝脏作为新陈代谢的中枢器官，特别容易受到营养紊乱的影响。文献中描述了与营养不良有关的两种主要形式的肝炎：饥饿肝炎和再喂养性肝炎。前者主要由肝细胞过度自噬和脱水、低血容量引起的缺氧引起，通常伴有临床症状。相比之下，后者通常与不适当再进食综合征有关，临床无症状，并在过快或高热量再进食期间发生，导致肝脂肪变性。本文基于国际文献综述，重点介绍神经性厌食症中与营养不良相关的肝脏疾病的诊断标准、病理生理机制（自噬、缺氧、脂肪变性）、特定风险和治疗管理。

引用次数: 0

Eosinophilic esophagitis; An updated review 嗜酸性食管炎;最新的评论

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2026-01-12 DOI: 10.1016/j.nupar.2025.12.002

Mohamed Guda , Aseel Almagrabi , Muhammed Zahri , Nada A. Alshaikh , Elsayed Ghoneem

Chronic inflammatory esophageal illness, also known as eosinophilic esophagitis (EoE), is mostly caused by immunological responses mediated by T-helper 2 (Th2) cells. Dysphagia, chest pain, and regurgitation are some of the symptoms that can be seen in both adults and children. Specific histological criteria usually lead to a diagnosis of the condition, which is marked by eosinophilic infiltration of the esophagus. It is more common in men, and the incidence and prevalence of EoE are on the rise, especially in high-income nations. The etiology of EoE is influenced by both hereditary and environmental factors. In order to manage EoE effectively, it is necessary to deal with the inflammatory and fibrostenotic components of the condition simultaneously. Efficacious dietary elimination programs, such as the 6-food elimination diet (6FED), are currently being used as therapies, along with proton pump inhibitors (PPIs) and topical corticosteroids. Dupilumab and other monoclonal antibodies that target the interleukin-4 receptor alpha are examples of biologic therapeutics that are showing promise as treatments, especially for patients who have not responded to conventional methods. Nevertheless, studies are still being conducted to determine the medicines’ long-term safety and effectiveness in various patient populations.

慢性炎症性食管疾病，又称嗜酸性食管炎（EoE），主要由t -辅助性2 （Th2）细胞介导的免疫反应引起。吞咽困难、胸痛和反流是成人和儿童都能看到的一些症状。具体的组织学标准通常导致诊断条件，其标志是食管嗜酸性粒细胞浸润。它在男性中更为常见，而且EoE的发病率和流行率正在上升，特别是在高收入国家。EoE的病因受遗传和环境因素的影响。为了有效地管理EoE，有必要同时处理炎症和纤维狭窄的成分。有效的饮食消除计划，如6种食物消除饮食（6FED），目前被用作治疗方法，以及质子泵抑制剂（PPIs）和局部皮质类固醇。Dupilumab和其他靶向白细胞介素-4受体α的单克隆抗体是生物疗法中显示出治疗前景的例子，特别是对于那些对传统方法没有反应的患者。然而，目前仍在进行研究，以确定这些药物在不同患者群体中的长期安全性和有效性。

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引用次数: 0

Impact of vitamin D supplementation on COVID-19 mortality: A systematic review and meta-analysis 补充维生素D对COVID-19死亡率的影响：系统综述和荟萃分析

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-12-26 DOI: 10.1016/j.nupar.2025.12.001

Azam Doustmohammadian , Maryam Amini , Bahareh Nikooyeh , Maryam Hajigholam-Saryazdi , Sepideh Alibeyk , Melika Hajjar

Background and aims

This study aimed to synthesize available evidence on the impact of vitamin D supplementation on COVID-19-related mortality through a systematic review and meta-analysis.

Methods

We systematically searched major databases for randomized controlled trials (RCTs), quasi-RCTs, and cluster-randomized trials published between October 1, 2019, and December 14, 2024, evaluating vitamin D supplementation in adult patients with laboratory-confirmed COVID-19. Studies were included if they reported mortality outcomes and compared vitamin D with placebo, standard care, or no intervention. Risk of bias was assessed using the Cochrane tool. Pooled odds ratios (ORs) were calculated using a random-effects model. Subgroup analyses were performed by age and sex composition. Publication bias was assessed via funnel plot symmetry and Egger's test.

Results

A total of 24 studies encompassing diverse populations across hospital, ICU, and community settings were included. Sample sizes ranged from 32 to 6200 participants, and intervention durations from 5 to 180 days. A pooled analysis revealed that vitamin D supplementation was associated with a significant 33% reduction in COVID-19 mortality (OR = 0.67; 95% CI: 0.46–0.98; P = 0.04), with moderate heterogeneity (I² = 48.2%). Subgroup analysis revealed a greater benefit among patients aged 65 years or older (minimal heterogeneity; I² = 4.3%) and among studies with more than 50% female participants (OR = 0.47; P = 0.01). No significant publication bias was detected.

Conclusions

Vitamin D may confer a protective effect against COVID-19 mortality, particularly among older adults and women. It represents a promising adjunctive strategy in COVID-19 management.

背景与目的本研究旨在通过系统回顾和荟萃分析，综合现有证据，证明补充维生素D对covid -19相关死亡率的影响。方法系统检索2019年10月1日至2024年12月14日发表的随机对照试验（rct）、准rct和集群随机试验的主要数据库，评估实验室确诊的成人COVID-19患者补充维生素D的效果。如果研究报告了死亡率结果，并将维生素D与安慰剂、标准治疗或无干预进行比较，则纳入研究。使用Cochrane工具评估偏倚风险。采用随机效应模型计算合并优势比（ORs）。按年龄和性别组成进行亚组分析。通过漏斗图对称和Egger检验评估发表偏倚。结果共纳入了24项研究，涵盖了医院、ICU和社区环境中的不同人群。样本量为32至6200名参与者，干预时间为5至180天。一项汇总分析显示，补充维生素D与COVID-19死亡率显著降低33%相关（OR = 0.67; 95% CI: 0.46-0.98; P = 0.04），具有中等异质性（I2 = 48.2%）。亚组分析显示，65岁及以上的患者（最小异质性；I2 = 4.3%）和女性参与者超过50%的研究（or = 0.47; P = 0.01）获益更大。未发现显著的发表偏倚。结论：维生素D可能具有预防COVID-19死亡率的保护作用，特别是在老年人和妇女中。它代表了一种很有前途的COVID-19管理辅助策略。

{"title":"Impact of vitamin D supplementation on COVID-19 mortality: A systematic review and meta-analysis","authors":"Azam Doustmohammadian , Maryam Amini , Bahareh Nikooyeh , Maryam Hajigholam-Saryazdi , Sepideh Alibeyk , Melika Hajjar","doi":"10.1016/j.nupar.2025.12.001","DOIUrl":"10.1016/j.nupar.2025.12.001","url":null,"abstract":"<div><h3>Background and aims</h3><div>This study aimed to synthesize available evidence on the impact of vitamin D supplementation on COVID-19-related mortality through a systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>We systematically searched major databases for randomized controlled trials (RCTs), quasi-RCTs, and cluster-randomized trials published between October 1, 2019, and December 14, 2024, evaluating vitamin D supplementation in adult patients with laboratory-confirmed COVID-19. Studies were included if they reported mortality outcomes and compared vitamin D with placebo, standard care, or no intervention. Risk of bias was assessed using the Cochrane tool. Pooled odds ratios (ORs) were calculated using a random-effects model. Subgroup analyses were performed by age and sex composition. Publication bias was assessed via funnel plot symmetry and Egger's test.</div></div><div><h3>Results</h3><div>A total of 24 studies encompassing diverse populations across hospital, ICU, and community settings were included. Sample sizes ranged from 32 to 6200 participants, and intervention durations from 5 to 180days. A pooled analysis revealed that vitamin D supplementation was associated with a significant 33% reduction in COVID-19 mortality (OR=0.67; 95% CI: 0.46–0.98; <em>P</em>  =48.2%). Subgroup analysis revealed a greater benefit among patients aged 65years or older (minimal heterogeneity; I<sup>2</sup>    =0.01). No significant publication bias was detected.</div></div><div><h3>Conclusions</h3><div>Vitamin D may confer a protective effect against COVID-19 mortality, particularly among older adults and women. It represents a promising adjunctive strategy in COVID-19 management.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103022"},"PeriodicalIF":0.4,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145841512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between coffee consumption and diarrhea: A cross-sectional study based on NHANES data 咖啡消费与腹泻之间的关系：基于NHANES数据的横断面研究

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-12-13 DOI: 10.1016/j.nupar.2025.11.004

Xiaoyang Zhang , Xiaomin Lin , Yahui Sun , Qingfeng Zeng , Yurong Liang , Wenfei Zha , Na Mi , Weijie Gu

Background

Coffee, one of the most globally consumed beverages with annual trade volumes exceeding $10 billion USD, has been epidemiologically associated with gastrointestinal effects due to its bioactive constituents, particularly caffeine. While previous studies have suggested potential impacts of coffee consumption on digestive physiology, the precise mechanisms and dose-response relationships remain poorly characterized. This cross-sectional investigation utilizes nationally representative data from the National Health and Nutrition Examination Survey (NHANES) to systematically examine the association between coffee intake patterns and diarrheal incidence in the U.S. adult population.

Methods

This study conducted a cross-sectional analysis of self-reported diarrhea and coffee intake from the 2005–2020 National Health and Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression models and restricted cubic splines (RCS) were employed to assess the association between coffee consumption and diarrhea, with results presented as odds ratios (ORs) and 95% confidence intervals (CIs).

Results

In this observational study, a total of 9544 eligible participants were included. After adjusting for potential confounding variables, higher coffee consumption was associated with an increased risk of diarrhea compared to lower coffee consumption, regardless of whether intake was measured in grams (P overall = 0.01) or cups (P overall = 0.04). Furthermore, a restricted cubic spline (RCS) analysis revealed a statistically significant linear positive correlation between coffee intake and diarrhea risk (P for nonlinearity < 0.05).

Conclusion

This population-based study demonstrates a statistically significant association between coffee intake and the incidence of diarrhea, regardless of whether consumption is measured in grams or cups. Therefore, individuals prone to gastrointestinal discomfort may benefit from moderating their coffee intake to reduce the risk of diarrhea.

咖啡是全球消费最多的饮料之一，年贸易额超过100亿美元，由于其生物活性成分，特别是咖啡因，在流行病学上与胃肠道效应有关。虽然之前的研究表明咖啡摄入对消化生理的潜在影响，但确切的机制和剂量-反应关系仍不清楚。这项横断面调查利用了全国健康与营养调查（NHANES）的全国代表性数据，系统地研究了美国成年人咖啡摄入模式与腹泻发病率之间的关系。方法本研究对2005-2020年全国健康与营养调查（NHANES）中自述腹泻和咖啡摄入量进行了横断面分析。采用加权多变量logistic回归模型和限制性三次样条（RCS）来评估咖啡摄入与腹泻之间的关系，结果以比值比（ORs）和95%置信区间（ci）表示。结果本观察性研究共纳入9544名符合条件的受试者。在调整了潜在的混杂变量后，与低咖啡摄入量相比，高咖啡摄入量与腹泻风险增加有关，无论摄入量是以克（P = 0.01）还是以杯（P = 0.04）来衡量。此外，限制性三次样条（RCS）分析显示，咖啡摄入量与腹泻风险之间存在统计学上显著的线性正相关（P为非线性<； 0.05）。结论：这项以人群为基础的研究表明，无论以克数还是杯数计算，咖啡摄入量与腹泻发生率之间都存在统计学上的显著关联。因此，容易出现肠胃不适的人可以通过减少咖啡的摄入量来降低腹泻的风险。

{"title":"The relationship between coffee consumption and diarrhea: A cross-sectional study based on NHANES data","authors":"Xiaoyang Zhang , Xiaomin Lin , Yahui Sun , Qingfeng Zeng , Yurong Liang , Wenfei Zha , Na Mi , Weijie Gu","doi":"10.1016/j.nupar.2025.11.004","DOIUrl":"10.1016/j.nupar.2025.11.004","url":null,"abstract":"<div><h3>Background</h3><div>Coffee, one of the most globally consumed beverages with annual trade volumes exceeding $10billion USD, has been epidemiologically associated with gastrointestinal effects due to its bioactive constituents, particularly caffeine. While previous studies have suggested potential impacts of coffee consumption on digestive physiology, the precise mechanisms and dose-response relationships remain poorly characterized. This cross-sectional investigation utilizes nationally representative data from the National Health and Nutrition Examination Survey (NHANES) to systematically examine the association between coffee intake patterns and diarrheal incidence in the U.S. adult population.</div></div><div><h3>Methods</h3><div>This study conducted a cross-sectional analysis of self-reported diarrhea and coffee intake from the 2005–2020 National Health and Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression models and restricted cubic splines (RCS) were employed to assess the association between coffee consumption and diarrhea, with results presented as odds ratios (ORs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>In this observational study, a total of 9544 eligible participants were included. After adjusting for potential confounding variables, higher coffee consumption was associated with an increased risk of diarrhea compared to lower coffee consumption, regardless of whether intake was measured in grams (<em>P</em> overall=0.01) or cups (<em>P</em> overall=0.04). Furthermore, a restricted cubic spline (RCS) analysis revealed a statistically significant linear positive correlation between coffee intake and diarrhea risk (<em>P</em> for nonlinearity<0.05).</div></div><div><h3>Conclusion</h3><div>This population-based study demonstrates a statistically significant association between coffee intake and the incidence of diarrhea, regardless of whether consumption is measured in grams or cups. Therefore, individuals prone to gastrointestinal discomfort may benefit from moderating their coffee intake to reduce the risk of diarrhea.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103020"},"PeriodicalIF":0.4,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue contents 问题内容

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-11-25 DOI: 10.1016/S0985-0562(25)00084-6

引用次数: 0

L’éditorial de la présidente de la SNFCM SNFCM主席的社论

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-11-13 DOI: 10.1016/j.nupar.2025.10.001

Francisca Joly

引用次数: 0

Molecular crosstalk between nutrition and osteosarcopenia in chronic liver disease: Pathophysiology and therapeutic prospects 慢性肝病中营养与骨骼肌减少的分子串扰：病理生理学和治疗前景

IF 0.4 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme

Pub Date : 2025-10-17 DOI: 10.1016/j.nupar.2025.09.002

Omer Qutaiba B. Allela , Abdulkareem Shareef , Hayder Naji Sameer , Ahmed Yaseen , Zainab H. Athab , Mohaned Adil

Objectives

Osteosarcopenia, defined by the simultaneous loss of bone and muscle mass, is a growing complication in chronic liver disease (CLD) that worsens frailty, fracture risk, and clinical outcomes. However, its nutritional and molecular drivers remain poorly understood. This scoping review examines the prevalence and clinical impact of osteosarcopenia in CLD and explores underlying nutritional and metabolic pathways to identify modifiable dietary targets for prevention and treatment.

Material and methods

A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science up to May 2025. Twenty-six eligible studies were included: seven focused on prevalence and outcomes, and nineteen investigated nutrient-related mechanisms. Thematic synthesis was guided by PRISMA-ScR methodology.

Results

Osteosarcopenia affects up to 20% of individuals with CLD and is independently associated with increased frailty, fractures, and mortality. Pathophysiological drivers include amino acid depletion, vitamin D deficiency, bile acid-related malabsorption, and endocrine dysregulation (e.g., reduced IGF-1, elevated myostatin). Inflammatory and oxidative pathways mediated by TNF-α, IL-6, and NF-κB further promote musculoskeletal catabolism. Nutrients such as leucine, arginine, glutamine, vitamin D, omega-3 fatty acids, and gut-derived short-chain fatty acids modulate critical anabolic and anti-catabolic pathways, including the mTORC1, Wnt/β-catenin, SIRT1/PGC-1α, and Nrf2 pathways.

Conclusion

Osteosarcopenia in CLD is not merely a secondary consequence of malnutrition but a distinct, nutritionally modifiable syndrome driven by disrupted inter-organ crosstalk. Dietary interventions targeting gut-muscle-bone-liver axes could represent safe, scalable, and cost-effective strategies to mitigate musculoskeletal decline in CLD. Integrating nutrition into hepatology care is a critical priority to enhance patient resilience, independence, and survival.

骨骼肌减少症是指骨量和肌肉量同时减少，是慢性肝病（CLD）中日益严重的并发症，它会加重虚弱、骨折风险和临床结果。然而，其营养和分子驱动因素仍然知之甚少。本综述研究了CLD中骨骼肌减少症的患病率和临床影响，并探讨了潜在的营养和代谢途径，以确定可改变的饮食目标来预防和治疗。材料与方法在PubMed、Scopus和Web of Science中进行了截至2025年5月的综合文献检索。纳入26项符合条件的研究：7项关注患病率和结果，19项调查营养相关机制。专题综合以PRISMA-ScR方法为指导。结果：高达20%的CLD患者罹患骨质减少症，并与虚弱、骨折和死亡率增加独立相关。病理生理驱动因素包括氨基酸消耗、维生素D缺乏、胆汁酸相关的吸收不良和内分泌失调（例如，IGF-1降低、肌肉生长抑制素升高）。TNF-α、IL-6和NF-κB介导的炎症和氧化途径进一步促进肌肉骨骼分解代谢。亮氨酸、精氨酸、谷氨酰胺、维生素D、omega-3脂肪酸和肠道衍生的短链脂肪酸等营养物质调节关键的合成代谢和抗分解代谢途径，包括mTORC1、Wnt/β-catenin、SIRT1/PGC-1α和Nrf2途径。结论CLD的骨骼肌减少症不仅仅是营养不良的继发性后果，而是一种由器官间串扰中断驱动的独特的、营养可改变的综合征。针对肠-肌-骨-肝轴的饮食干预可能是一种安全、可扩展且具有成本效益的策略，可缓解CLD的肌肉骨骼衰退。将营养纳入肝病护理是提高患者适应能力、独立性和生存率的关键优先事项。

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引用次数: 0