Pub Date : 2026-01-12DOI: 10.1016/j.nupar.2025.12.002
Mohamed Guda , Aseel Almagrabi , Muhammed Zahri , Nada A. Alshaikh , Elsayed Ghoneem
Chronic inflammatory esophageal illness, also known as eosinophilic esophagitis (EoE), is mostly caused by immunological responses mediated by T-helper 2 (Th2) cells. Dysphagia, chest pain, and regurgitation are some of the symptoms that can be seen in both adults and children. Specific histological criteria usually lead to a diagnosis of the condition, which is marked by eosinophilic infiltration of the esophagus. It is more common in men, and the incidence and prevalence of EoE are on the rise, especially in high-income nations. The etiology of EoE is influenced by both hereditary and environmental factors. In order to manage EoE effectively, it is necessary to deal with the inflammatory and fibrostenotic components of the condition simultaneously. Efficacious dietary elimination programs, such as the 6-food elimination diet (6FED), are currently being used as therapies, along with proton pump inhibitors (PPIs) and topical corticosteroids. Dupilumab and other monoclonal antibodies that target the interleukin-4 receptor alpha are examples of biologic therapeutics that are showing promise as treatments, especially for patients who have not responded to conventional methods. Nevertheless, studies are still being conducted to determine the medicines’ long-term safety and effectiveness in various patient populations.
{"title":"Eosinophilic esophagitis; An updated review","authors":"Mohamed Guda , Aseel Almagrabi , Muhammed Zahri , Nada A. Alshaikh , Elsayed Ghoneem","doi":"10.1016/j.nupar.2025.12.002","DOIUrl":"10.1016/j.nupar.2025.12.002","url":null,"abstract":"<div><div>Chronic inflammatory esophageal illness, also known as eosinophilic esophagitis (EoE), is mostly caused by immunological responses mediated by T-helper 2 (Th2) cells. Dysphagia, chest pain, and regurgitation are some of the symptoms that can be seen in both adults and children. Specific histological criteria usually lead to a diagnosis of the condition, which is marked by eosinophilic infiltration of the esophagus. It is more common in men, and the incidence and prevalence of EoE are on the rise, especially in high-income nations. The etiology of EoE is influenced by both hereditary and environmental factors. In order to manage EoE effectively, it is necessary to deal with the inflammatory and fibrostenotic components of the condition simultaneously. Efficacious dietary elimination programs, such as the 6-food elimination diet (6FED), are currently being used as therapies, along with proton pump inhibitors (PPIs) and topical corticosteroids. Dupilumab and other monoclonal antibodies that target the interleukin-4 receptor alpha are examples of biologic therapeutics that are showing promise as treatments, especially for patients who have not responded to conventional methods. Nevertheless, studies are still being conducted to determine the medicines’ long-term safety and effectiveness in various patient populations.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103023"},"PeriodicalIF":0.4,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to synthesize available evidence on the impact of vitamin D supplementation on COVID-19-related mortality through a systematic review and meta-analysis.
Methods
We systematically searched major databases for randomized controlled trials (RCTs), quasi-RCTs, and cluster-randomized trials published between October 1, 2019, and December 14, 2024, evaluating vitamin D supplementation in adult patients with laboratory-confirmed COVID-19. Studies were included if they reported mortality outcomes and compared vitamin D with placebo, standard care, or no intervention. Risk of bias was assessed using the Cochrane tool. Pooled odds ratios (ORs) were calculated using a random-effects model. Subgroup analyses were performed by age and sex composition. Publication bias was assessed via funnel plot symmetry and Egger's test.
Results
A total of 24 studies encompassing diverse populations across hospital, ICU, and community settings were included. Sample sizes ranged from 32 to 6200 participants, and intervention durations from 5 to 180 days. A pooled analysis revealed that vitamin D supplementation was associated with a significant 33% reduction in COVID-19 mortality (OR = 0.67; 95% CI: 0.46–0.98; P = 0.04), with moderate heterogeneity (I2 = 48.2%). Subgroup analysis revealed a greater benefit among patients aged 65 years or older (minimal heterogeneity; I2 = 4.3%) and among studies with more than 50% female participants (OR = 0.47; P = 0.01). No significant publication bias was detected.
Conclusions
Vitamin D may confer a protective effect against COVID-19 mortality, particularly among older adults and women. It represents a promising adjunctive strategy in COVID-19 management.
背景与目的本研究旨在通过系统回顾和荟萃分析，综合现有证据，证明补充维生素D对covid -19相关死亡率的影响。方法系统检索2019年10月1日至2024年12月14日发表的随机对照试验（rct）、准rct和集群随机试验的主要数据库，评估实验室确诊的成人COVID-19患者补充维生素D的效果。如果研究报告了死亡率结果，并将维生素D与安慰剂、标准治疗或无干预进行比较，则纳入研究。使用Cochrane工具评估偏倚风险。采用随机效应模型计算合并优势比（ORs）。按年龄和性别组成进行亚组分析。通过漏斗图对称和Egger检验评估发表偏倚。结果共纳入了24项研究，涵盖了医院、ICU和社区环境中的不同人群。样本量为32至6200名参与者，干预时间为5至180天。一项汇总分析显示，补充维生素D与COVID-19死亡率显著降低33%相关（OR = 0.67; 95% CI: 0.46-0.98; P = 0.04），具有中等异质性（I2 = 48.2%）。亚组分析显示，65岁及以上的患者（最小异质性；I2 = 4.3%）和女性参与者超过50%的研究（or = 0.47; P = 0.01）获益更大。未发现显著的发表偏倚。结论：维生素D可能具有预防COVID-19死亡率的保护作用，特别是在老年人和妇女中。它代表了一种很有前途的COVID-19管理辅助策略。
{"title":"Impact of vitamin D supplementation on COVID-19 mortality: A systematic review and meta-analysis","authors":"Azam Doustmohammadian , Maryam Amini , Bahareh Nikooyeh , Maryam Hajigholam-Saryazdi , Sepideh Alibeyk , Melika Hajjar","doi":"10.1016/j.nupar.2025.12.001","DOIUrl":"10.1016/j.nupar.2025.12.001","url":null,"abstract":"<div><h3>Background and aims</h3><div>This study aimed to synthesize available evidence on the impact of vitamin D supplementation on COVID-19-related mortality through a systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>We systematically searched major databases for randomized controlled trials (RCTs), quasi-RCTs, and cluster-randomized trials published between October 1, 2019, and December 14, 2024, evaluating vitamin D supplementation in adult patients with laboratory-confirmed COVID-19. Studies were included if they reported mortality outcomes and compared vitamin D with placebo, standard care, or no intervention. Risk of bias was assessed using the Cochrane tool. Pooled odds ratios (ORs) were calculated using a random-effects model. Subgroup analyses were performed by age and sex composition. Publication bias was assessed via funnel plot symmetry and Egger's test.</div></div><div><h3>Results</h3><div>A total of 24 studies encompassing diverse populations across hospital, ICU, and community settings were included. Sample sizes ranged from 32 to 6200 participants, and intervention durations from 5 to 180<!--> <!-->days. A pooled analysis revealed that vitamin D supplementation was associated with a significant 33% reduction in COVID-19 mortality (OR<!--> <!-->=<!--> <!-->0.67; 95% CI: 0.46–0.98; <em>P</em> <!-->=<!--> <!-->0.04), with moderate heterogeneity (I<sup>2</sup> <!-->=<!--> <!-->48.2%). Subgroup analysis revealed a greater benefit among patients aged 65<!--> <!-->years or older (minimal heterogeneity; I<sup>2</sup> <!-->=<!--> <!-->4.3%) and among studies with more than 50% female participants (OR<!--> <!-->=<!--> <!-->0.47; <em>P</em> <!-->=<!--> <!-->0.01). No significant publication bias was detected.</div></div><div><h3>Conclusions</h3><div>Vitamin D may confer a protective effect against COVID-19 mortality, particularly among older adults and women. It represents a promising adjunctive strategy in COVID-19 management.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103022"},"PeriodicalIF":0.4,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145841512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-13DOI: 10.1016/j.nupar.2025.11.004
Xiaoyang Zhang , Xiaomin Lin , Yahui Sun , Qingfeng Zeng , Yurong Liang , Wenfei Zha , Na Mi , Weijie Gu
Background
Coffee, one of the most globally consumed beverages with annual trade volumes exceeding $10 billion USD, has been epidemiologically associated with gastrointestinal effects due to its bioactive constituents, particularly caffeine. While previous studies have suggested potential impacts of coffee consumption on digestive physiology, the precise mechanisms and dose-response relationships remain poorly characterized. This cross-sectional investigation utilizes nationally representative data from the National Health and Nutrition Examination Survey (NHANES) to systematically examine the association between coffee intake patterns and diarrheal incidence in the U.S. adult population.
Methods
This study conducted a cross-sectional analysis of self-reported diarrhea and coffee intake from the 2005–2020 National Health and Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression models and restricted cubic splines (RCS) were employed to assess the association between coffee consumption and diarrhea, with results presented as odds ratios (ORs) and 95% confidence intervals (CIs).
Results
In this observational study, a total of 9544 eligible participants were included. After adjusting for potential confounding variables, higher coffee consumption was associated with an increased risk of diarrhea compared to lower coffee consumption, regardless of whether intake was measured in grams (P overall = 0.01) or cups (P overall = 0.04). Furthermore, a restricted cubic spline (RCS) analysis revealed a statistically significant linear positive correlation between coffee intake and diarrhea risk (P for nonlinearity < 0.05).
Conclusion
This population-based study demonstrates a statistically significant association between coffee intake and the incidence of diarrhea, regardless of whether consumption is measured in grams or cups. Therefore, individuals prone to gastrointestinal discomfort may benefit from moderating their coffee intake to reduce the risk of diarrhea.
{"title":"The relationship between coffee consumption and diarrhea: A cross-sectional study based on NHANES data","authors":"Xiaoyang Zhang , Xiaomin Lin , Yahui Sun , Qingfeng Zeng , Yurong Liang , Wenfei Zha , Na Mi , Weijie Gu","doi":"10.1016/j.nupar.2025.11.004","DOIUrl":"10.1016/j.nupar.2025.11.004","url":null,"abstract":"<div><h3>Background</h3><div>Coffee, one of the most globally consumed beverages with annual trade volumes exceeding $10<!--> <!-->billion USD, has been epidemiologically associated with gastrointestinal effects due to its bioactive constituents, particularly caffeine. While previous studies have suggested potential impacts of coffee consumption on digestive physiology, the precise mechanisms and dose-response relationships remain poorly characterized. This cross-sectional investigation utilizes nationally representative data from the National Health and Nutrition Examination Survey (NHANES) to systematically examine the association between coffee intake patterns and diarrheal incidence in the U.S. adult population.</div></div><div><h3>Methods</h3><div>This study conducted a cross-sectional analysis of self-reported diarrhea and coffee intake from the 2005–2020 National Health and Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression models and restricted cubic splines (RCS) were employed to assess the association between coffee consumption and diarrhea, with results presented as odds ratios (ORs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>In this observational study, a total of 9544 eligible participants were included. After adjusting for potential confounding variables, higher coffee consumption was associated with an increased risk of diarrhea compared to lower coffee consumption, regardless of whether intake was measured in grams (<em>P</em> overall<!--> <!-->=<!--> <!-->0.01) or cups (<em>P</em> overall<!--> <!-->=<!--> <!-->0.04). Furthermore, a restricted cubic spline (RCS) analysis revealed a statistically significant linear positive correlation between coffee intake and diarrhea risk (<em>P</em> for nonlinearity<!--> <!--><<!--> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>This population-based study demonstrates a statistically significant association between coffee intake and the incidence of diarrhea, regardless of whether consumption is measured in grams or cups. Therefore, individuals prone to gastrointestinal discomfort may benefit from moderating their coffee intake to reduce the risk of diarrhea.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"40 1","pages":"Article 103020"},"PeriodicalIF":0.4,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.nupar.2025.10.001
Francisca Joly
{"title":"L’éditorial de la présidente de la SNFCM","authors":"Francisca Joly","doi":"10.1016/j.nupar.2025.10.001","DOIUrl":"10.1016/j.nupar.2025.10.001","url":null,"abstract":"","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Page 229"},"PeriodicalIF":0.4,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-17DOI: 10.1016/j.nupar.2025.09.002
Omer Qutaiba B. Allela , Abdulkareem Shareef , Hayder Naji Sameer , Ahmed Yaseen , Zainab H. Athab , Mohaned Adil
Objectives
Osteosarcopenia, defined by the simultaneous loss of bone and muscle mass, is a growing complication in chronic liver disease (CLD) that worsens frailty, fracture risk, and clinical outcomes. However, its nutritional and molecular drivers remain poorly understood. This scoping review examines the prevalence and clinical impact of osteosarcopenia in CLD and explores underlying nutritional and metabolic pathways to identify modifiable dietary targets for prevention and treatment.
Material and methods
A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science up to May 2025. Twenty-six eligible studies were included: seven focused on prevalence and outcomes, and nineteen investigated nutrient-related mechanisms. Thematic synthesis was guided by PRISMA-ScR methodology.
Results
Osteosarcopenia affects up to 20% of individuals with CLD and is independently associated with increased frailty, fractures, and mortality. Pathophysiological drivers include amino acid depletion, vitamin D deficiency, bile acid-related malabsorption, and endocrine dysregulation (e.g., reduced IGF-1, elevated myostatin). Inflammatory and oxidative pathways mediated by TNF-α, IL-6, and NF-κB further promote musculoskeletal catabolism. Nutrients such as leucine, arginine, glutamine, vitamin D, omega-3 fatty acids, and gut-derived short-chain fatty acids modulate critical anabolic and anti-catabolic pathways, including the mTORC1, Wnt/β-catenin, SIRT1/PGC-1α, and Nrf2 pathways.
Conclusion
Osteosarcopenia in CLD is not merely a secondary consequence of malnutrition but a distinct, nutritionally modifiable syndrome driven by disrupted inter-organ crosstalk. Dietary interventions targeting gut-muscle-bone-liver axes could represent safe, scalable, and cost-effective strategies to mitigate musculoskeletal decline in CLD. Integrating nutrition into hepatology care is a critical priority to enhance patient resilience, independence, and survival.
骨骼肌减少症是指骨量和肌肉量同时减少，是慢性肝病（CLD）中日益严重的并发症，它会加重虚弱、骨折风险和临床结果。然而，其营养和分子驱动因素仍然知之甚少。本综述研究了CLD中骨骼肌减少症的患病率和临床影响，并探讨了潜在的营养和代谢途径，以确定可改变的饮食目标来预防和治疗。材料与方法在PubMed、Scopus和Web of Science中进行了截至2025年5月的综合文献检索。纳入26项符合条件的研究：7项关注患病率和结果，19项调查营养相关机制。专题综合以PRISMA-ScR方法为指导。结果：高达20%的CLD患者罹患骨质减少症，并与虚弱、骨折和死亡率增加独立相关。病理生理驱动因素包括氨基酸消耗、维生素D缺乏、胆汁酸相关的吸收不良和内分泌失调（例如，IGF-1降低、肌肉生长抑制素升高）。TNF-α、IL-6和NF-κB介导的炎症和氧化途径进一步促进肌肉骨骼分解代谢。亮氨酸、精氨酸、谷氨酰胺、维生素D、omega-3脂肪酸和肠道衍生的短链脂肪酸等营养物质调节关键的合成代谢和抗分解代谢途径，包括mTORC1、Wnt/β-catenin、SIRT1/PGC-1α和Nrf2途径。结论CLD的骨骼肌减少症不仅仅是营养不良的继发性后果，而是一种由器官间串扰中断驱动的独特的、营养可改变的综合征。针对肠-肌-骨-肝轴的饮食干预可能是一种安全、可扩展且具有成本效益的策略，可缓解CLD的肌肉骨骼衰退。将营养纳入肝病护理是提高患者适应能力、独立性和生存率的关键优先事项。
{"title":"Molecular crosstalk between nutrition and osteosarcopenia in chronic liver disease: Pathophysiology and therapeutic prospects","authors":"Omer Qutaiba B. Allela , Abdulkareem Shareef , Hayder Naji Sameer , Ahmed Yaseen , Zainab H. Athab , Mohaned Adil","doi":"10.1016/j.nupar.2025.09.002","DOIUrl":"10.1016/j.nupar.2025.09.002","url":null,"abstract":"<div><h3>Objectives</h3><div>Osteosarcopenia, defined by the simultaneous loss of bone and muscle mass, is a growing complication in chronic liver disease (CLD) that worsens frailty, fracture risk, and clinical outcomes. However, its nutritional and molecular drivers remain poorly understood. This scoping review examines the prevalence and clinical impact of osteosarcopenia in CLD and explores underlying nutritional and metabolic pathways to identify modifiable dietary targets for prevention and treatment.</div></div><div><h3>Material and methods</h3><div>A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science up to May 2025. Twenty-six eligible studies were included: seven focused on prevalence and outcomes, and nineteen investigated nutrient-related mechanisms. Thematic synthesis was guided by PRISMA-ScR methodology.</div></div><div><h3>Results</h3><div>Osteosarcopenia affects up to 20% of individuals with CLD and is independently associated with increased frailty, fractures, and mortality. Pathophysiological drivers include amino acid depletion, vitamin D deficiency, bile acid-related malabsorption, and endocrine dysregulation (e.g., reduced IGF-1, elevated myostatin). Inflammatory and oxidative pathways mediated by TNF-α, IL-6, and NF-κB further promote musculoskeletal catabolism. Nutrients such as leucine, arginine, glutamine, vitamin D, omega-3 fatty acids, and gut-derived short-chain fatty acids modulate critical anabolic and anti-catabolic pathways, including the mTORC1, Wnt/β-catenin, SIRT1/PGC-1α, and Nrf2 pathways.</div></div><div><h3>Conclusion</h3><div>Osteosarcopenia in CLD is not merely a secondary consequence of malnutrition but a distinct, nutritionally modifiable syndrome driven by disrupted inter-organ crosstalk. Dietary interventions targeting gut-muscle-bone-liver axes could represent safe, scalable, and cost-effective strategies to mitigate musculoskeletal decline in CLD. Integrating nutrition into hepatology care is a critical priority to enhance patient resilience, independence, and survival.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 282-291"},"PeriodicalIF":0.4,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-23DOI: 10.1016/j.nupar.2025.09.001
Mohammad Ali Izadi, Farhad Daryanoosh
Muscle mass is a key factor in the performance and health of athletes. Skeletal muscle mass is determined by the balance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). One of the goals of strength athletes is to have more muscle mass through exercise, nutritional, and supplementation strategies. From a supplementation perspective, creatine supplementation, especially when combined with resistance training, is recognized as a strategy for increasing lean tissue mass and muscle strength. The mechanisms of action of creatine in skeletal muscle include increased energy availability, IGF-1 signaling, activation of the mTOR pathway, increased intracellular water, activation of satellite cells, reduced muscle damage, and improved recovery, which are discussed in this review. This article provides a comprehensive review of the current literature on creatine supplementation and its effects on MPS in athletes. We review the mechanisms through which creatine exerts its effects, its implications for different types of exercise training, and considerations for optimal dosing protocols.
{"title":"The effect of creatine supplementation on muscle protein synthesis in athletes: A review","authors":"Mohammad Ali Izadi, Farhad Daryanoosh","doi":"10.1016/j.nupar.2025.09.001","DOIUrl":"10.1016/j.nupar.2025.09.001","url":null,"abstract":"<div><div>Muscle mass is a key factor in the performance and health of athletes. Skeletal muscle mass is determined by the balance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). One of the goals of strength athletes is to have more muscle mass through exercise, nutritional, and supplementation strategies. From a supplementation perspective, creatine supplementation, especially when combined with resistance training, is recognized as a strategy for increasing lean tissue mass and muscle strength. The mechanisms of action of creatine in skeletal muscle include increased energy availability, IGF-1 signaling, activation of the mTOR pathway, increased intracellular water, activation of satellite cells, reduced muscle damage, and improved recovery, which are discussed in this review. This article provides a comprehensive review of the current literature on creatine supplementation and its effects on MPS in athletes. We review the mechanisms through which creatine exerts its effects, its implications for different types of exercise training, and considerations for optimal dosing protocols.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 273-281"},"PeriodicalIF":0.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-17DOI: 10.1016/j.nupar.2025.08.002
Runmei Pan , Liangmei Ouyang , Xiying Zhang, Jimei Huang, Yan Xiao , Yingfang Chen
Objective
This study aimed to investigate the impact of optimizing nosocomial infection management plus nutritional support on the incidence of nosocomial infections and the quantity of indoor bacteria in surgical patients.
Methods
A retrospective analysis was conducted on 400 surgical patients, rolled into Group A (n = 100, traditional nosocomial infection management + simple nutritional support), Group B (n = 100, traditional nosocomial infection management + complex nutritional support), Group C (n = 100, optimized nosocomial infection management + simple nutritional support), and Group D (n = 100, optimized nosocomial infection management + complex nutritional support). The incidence of nosocomial infections, indoor bacterial counts, and patient satisfaction were analyzed among the four groups.
Results
The postoperative air and hand bacterial counts in Groups C and D were lower than those in Groups A and B (P < 0.05). The preoperative preparation time and surgical time in Groups C and D were shorter than those in Groups A and B (P < 0.05). Patients in Groups C and D exhibited higher scores in nosocomial infection management quality compared to Groups A and B (P < 0.05). The number of highly satisfied patients in Group D was higher than that in Groups A, B, and C (P < 0.05).
Conclusion
Optimizing nosocomial infection management combined with complex nutritional support can reduce the counts of airborne and hand bacteria in surgical rooms, decrease the incidence of nosocomial infections, and demonstrate positive practical effects.
{"title":"Influence of optimized nosocomial infection management model combined with nutritional support on the incidence of nosocomial infections and indoor bacterial count in surgical room patients","authors":"Runmei Pan , Liangmei Ouyang , Xiying Zhang, Jimei Huang, Yan Xiao , Yingfang Chen","doi":"10.1016/j.nupar.2025.08.002","DOIUrl":"10.1016/j.nupar.2025.08.002","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the impact of optimizing nosocomial infection management plus nutritional support on the incidence of nosocomial infections and the quantity of indoor bacteria in surgical patients.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 400 surgical patients, rolled into Group A (<em>n</em> <!-->=<!--> <!-->100, traditional nosocomial infection management<!--> <!-->+<!--> <!-->simple nutritional support), Group B (<em>n</em> <!-->=<!--> <!-->100, traditional nosocomial infection management<!--> <!-->+<!--> <!-->complex nutritional support), Group C (<em>n</em> <!-->=<!--> <!-->100, optimized nosocomial infection management<!--> <!-->+<!--> <!-->simple nutritional support), and Group D (<em>n</em> <!-->=<!--> <!-->100, optimized nosocomial infection management<!--> <!-->+<!--> <!-->complex nutritional support). The incidence of nosocomial infections, indoor bacterial counts, and patient satisfaction were analyzed among the four groups.</div></div><div><h3>Results</h3><div>The postoperative air and hand bacterial counts in Groups C and D were lower than those in Groups A and B (<em>P</em> <!--><<!--> <!-->0.05). The preoperative preparation time and surgical time in Groups C and D were shorter than those in Groups A and B (<em>P</em> <!--><<!--> <!-->0.05). Patients in Groups C and D exhibited higher scores in nosocomial infection management quality compared to Groups A and B (<em>P</em> <!--><<!--> <!-->0.05). The number of highly satisfied patients in Group D was higher than that in Groups A, B, and C (<em>P</em> <!--><<!--> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>Optimizing nosocomial infection management combined with complex nutritional support can reduce the counts of airborne and hand bacteria in surgical rooms, decrease the incidence of nosocomial infections, and demonstrate positive practical effects.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 302-309"},"PeriodicalIF":0.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-17DOI: 10.1016/j.nupar.2025.08.004
Zi Zeng , Hua Wei , Yuejuan Dong , Sijin Sun , Zhuoma Sunu
Objective
To evaluate the effects of various dietary regimens on adult patients with metabolic dysfunction-associated steatotic liver disease.
Methods
Randomized controlled trials of various dietary regimens in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), published up to October 6th, 2024, were included in this study. The Cochrane Collaboration tool was employed to assess the risk of bias for quality evaluation. STATA 17.0 software was utilized for both pairwise meta-analysis and a series of network meta-analyses (NMA).
Results
A total of 19 randomized controlled trials (RCTs) from 22 studies involving 1288 patients were included, focusing on 12 different dietary approaches. The findings indicated that the recommended diet varied based on different outcome measures. The very low-calorie ketogenic diet (VLCKD) was found to be the most effective for reducing body weight, body mass index (BMI), and waist circumference. In contrast, the Dietary Approaches to Stop Hypertension (DASH) was more effective in lowering blood lipid levels. Regarding liver enzyme indicators, the results were inconsistent, leading to no specific recommendations. Additionally, the low free sugar diet (LFSD) demonstrated greater benefits in improving glucose metabolism indicators.
Conclusions
The VLCKD is more effective for improving anthropometric indicators, while the DASH diet is more suitable for enhancing lipid indicators. There is currently no standardized dietary recommendation for alleviating liver enzyme indicators. The LFSD has proven to be more effective for parameters related to glucose metabolism indicators. Clinical applications should be tailored to the individual circumstances of each patient.
{"title":"What diet is optimal in adults with metabolic dysfunction-associated steatotic liver disease? A systematic review and network meta-analysis","authors":"Zi Zeng , Hua Wei , Yuejuan Dong , Sijin Sun , Zhuoma Sunu","doi":"10.1016/j.nupar.2025.08.004","DOIUrl":"10.1016/j.nupar.2025.08.004","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effects of various dietary regimens on adult patients with metabolic dysfunction-associated steatotic liver disease.</div></div><div><h3>Methods</h3><div>Randomized controlled trials of various dietary regimens in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), published up to October 6th, 2024, were included in this study. The Cochrane Collaboration tool was employed to assess the risk of bias for quality evaluation. STATA 17.0 software was utilized for both pairwise meta-analysis and a series of network meta-analyses (NMA).</div></div><div><h3>Results</h3><div>A total of 19 randomized controlled trials (RCTs) from 22 studies involving 1288 patients were included, focusing on 12 different dietary approaches. The findings indicated that the recommended diet varied based on different outcome measures. The very low-calorie ketogenic diet (VLCKD) was found to be the most effective for reducing body weight, body mass index (BMI), and waist circumference. In contrast, the Dietary Approaches to Stop Hypertension (DASH) was more effective in lowering blood lipid levels. Regarding liver enzyme indicators, the results were inconsistent, leading to no specific recommendations. Additionally, the low free sugar diet (LFSD) demonstrated greater benefits in improving glucose metabolism indicators.</div></div><div><h3>Conclusions</h3><div>The VLCKD is more effective for improving anthropometric indicators, while the DASH diet is more suitable for enhancing lipid indicators. There is currently no standardized dietary recommendation for alleviating liver enzyme indicators. The LFSD has proven to be more effective for parameters related to glucose metabolism indicators. Clinical applications should be tailored to the individual circumstances of each patient.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 319-333"},"PeriodicalIF":0.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145595040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-04DOI: 10.1016/j.nupar.2025.08.003
Wangyang Bai , Yi Ling , Hangqi Chen , Xiaofei Ye , Jinfang Xu , Xiaojing Guo , Jia He
Objectives
It remains unclear whether the combined use of the triglyceride glucose index (TyG) and body roundness index (BRI), specifically the triglyceride glucose-body roundness index (TyG-BRI), is associated with the incidence of cardiovascular diseases (CVD). This study aimed to investigate the joint association of the TyG and BRI with CVD among middle-aged and elderly adults with abnormal glucose metabolism.
Material and methods
This study obtained four national waves data from China Health and Retirement Longitudinal Study. Patients age ≥ 45 years with abnormal glucose metabolism were included. The primary outcome was incident CVD. Multivariable-adjusted Cox proportional hazards regression models were employed to assess the joint association of the TyG, BRI and the TyG-BRI with outcomes.
Results
A total of 4805 Chinese adults with abnormal glucose metabolism were enrolled in this study. In the follow-up, 899 participants (18.7%) experienced CVD events. Compared to the first quartile of the index, the fourth quartile of TyG-BRI was associated with increased risk for CVD by 53.8% (HR, 1.538 [95% CI, 1.249–1.893]). Mediation effects analyses revealed that high TyG index significantly mediated 4.545% (P = 0.016) of the association between a high BRI and CVD incidence, while BRI simultaneously mediated 14.583% (P < 0.001) of the association between high TyG index and CVD.
Conclusions
TyG, BRI, and the combined TyG-BRI index are independently associated with increased risks of CVD among middle-aged and older adults with abnormal glucose metabolism in China. These indicators are easy to obtain and can be implemented in resource-limited primary hospitals to assist clinical practitioners in early screening and assessment of cardiovascular disease risk in patients with abnormal glucose metabolism.
{"title":"Joint association of the triglyceride glucose and body roundness index with cardiovascular diseases among Chinese middle and old-aged adults with abnormal glucose metabolism: A nationwide prospective cohort study","authors":"Wangyang Bai , Yi Ling , Hangqi Chen , Xiaofei Ye , Jinfang Xu , Xiaojing Guo , Jia He","doi":"10.1016/j.nupar.2025.08.003","DOIUrl":"10.1016/j.nupar.2025.08.003","url":null,"abstract":"<div><h3>Objectives</h3><div>It remains unclear whether the combined use of the triglyceride glucose index (TyG) and body roundness index (BRI), specifically the triglyceride glucose-body roundness index (TyG-BRI), is associated with the incidence of cardiovascular diseases (CVD). This study aimed to investigate the joint association of the TyG and BRI with CVD among middle-aged and elderly adults with abnormal glucose metabolism.</div></div><div><h3>Material and methods</h3><div>This study obtained four national waves data from China Health and Retirement Longitudinal Study. Patients age ≥<!--> <!-->45 years with abnormal glucose metabolism were included. The primary outcome was incident CVD. Multivariable-adjusted Cox proportional hazards regression models were employed to assess the joint association of the TyG, BRI and the TyG-BRI with outcomes.</div></div><div><h3>Results</h3><div>A total of 4805 Chinese adults with abnormal glucose metabolism were enrolled in this study. In the follow-up, 899 participants (18.7%) experienced CVD events. Compared to the first quartile of the index, the fourth quartile of TyG-BRI was associated with increased risk for CVD by 53.8% (HR, 1.538 [95% CI, 1.249–1.893]). Mediation effects analyses revealed that high TyG index significantly mediated 4.545% (<em>P</em> <!-->=<!--> <!-->0.016) of the association between a high BRI and CVD incidence, while BRI simultaneously mediated 14.583% (<em>P</em> <!--><<!--> <!-->0.001) of the association between high TyG index and CVD.</div></div><div><h3>Conclusions</h3><div>TyG, BRI, and the combined TyG-BRI index are independently associated with increased risks of CVD among middle-aged and older adults with abnormal glucose metabolism in China. These indicators are easy to obtain and can be implemented in resource-limited primary hospitals to assist clinical practitioners in early screening and assessment of cardiovascular disease risk in patients with abnormal glucose metabolism.</div></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"39 4","pages":"Pages 310-318"},"PeriodicalIF":0.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145595039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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