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IF 0.5 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-28 DOI: 10.1016/S0985-0562(24)00108-0
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引用次数: 0
Applicability of Global Leadership Initiative on Malnutrition (GLIM) criteria in nutrition risk screening for patients over 60 years old with digestive system tumors – A retrospective study 全球营养不良领导倡议(GLIM)标准在 60 岁以上消化系统肿瘤患者营养风险筛查中的适用性 - 一项回顾性研究
IF 0.5 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-10 DOI: 10.1016/j.nupar.2024.06.002

Objective

This study aimed to identify the most effective nutritional risk screening tool for elderly patients with digestive system tumors.

Methods

Nutritional risk screening was performed using Nutritional Risk Screening 2002 (NRS2002), prognostic nutritional index (PNI) and Geriatric Nutritional Risk Index (GNRI) for elderly patients who underwent surgical resection of digestive tumor. Comparative analysis of each nutritional screening tool was conducted through Kappa test and ROC curve.

Results

Malnourished individuals diagnosed by the Global Leadership Initiative on Malnutrition (GLIM) criteria had lower levels of hematological parameters (serum albumin, pre-albumin, total protein and hemoglobin) and poorer body composition parameters (body mass index, body fat percentage, edema index, upper arm muscle circumference, skeletal muscle index, and phase angle; P < 0.05). NRS2002 demonstrated a sensitivity of 75.56% and specificity of 38.16% under the GLIM criteria, showing moderate agreement (Kappa = 0.346, P < 0.001). PNI had an average sensitivity of 71.11% and the highest specificity at 87.23%, but exhibited no consistency with GLIM (Kappa = 0.152, P = 0.062). GNRI showed the highest sensitivity at 91.11% and general specificity at 37.14%, aligning closely with GLIM criteria (Kappa = 0.711, P < 0.001). GNRI had the highest predictive value (AUC = 0.870, 95% CI: 0.801–0.939), followed by NRS2002 (AUC = 0.687, 95% CI: 0.589–0.785). Patients diagnosed with malnutrition via GNRI-GLIM exhibited higher rates of surgical site infection (χ2 = 15.534, P < 0.001) and 3-month readmission (χ2 = 4.499, P = 0.034).

Conclusion

GNRI and NRS2002 demonstrate good performance as GLIM criteria for nutritional screening in elderly patients with digestive tumors, with GNRI being potentially more suitable. Moreover, GNRI-GLIM can predict short-term prognosis in these patients.

方法采用营养风险筛查2002(NRS2002)、预后营养指数(PNI)和老年营养风险指数(GNRI)对接受消化系统肿瘤手术切除的老年患者进行营养风险筛查。结果根据全球领导力营养不良倡议(GLIM)标准诊断出的营养不良者血液学参数(血清白蛋白、前白蛋白、总蛋白和血红蛋白)水平较低,身体成分参数(体重指数、体脂百分比、水肿指数、上臂肌围、骨骼肌指数和相位角;P <0.05)较差。根据 GLIM 标准,NRS2002 的灵敏度为 75.56%,特异性为 38.16%,显示出中等程度的一致性(Kappa = 0.346,P <0.001)。PNI 的平均灵敏度为 71.11%,特异性最高,为 87.23%,但与 GLIM 没有一致性(Kappa = 0.152,P = 0.062)。GNRI 的灵敏度最高,为 91.11%,特异性最高,为 37.14%,与 GLIM 标准非常一致(Kappa = 0.711,P <0.001)。GNRI 的预测值最高(AUC = 0.870,95% CI:0.801-0.939),其次是 NRS2002(AUC = 0.687,95% CI:0.589-0.785)。结论GNRI 和 NRS2002 作为消化系统肿瘤老年患者营养筛查的 GLIM 标准表现良好,其中 GNRI 可能更适合。此外,GNRI-GLIM 还能预测这些患者的短期预后。
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引用次数: 0
Associations between Diet Inflammatory Index Scores and nutritional status in chronic kidney disease patients 慢性肾病患者饮食炎症指数评分与营养状况之间的关系
IF 0.5 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-09 DOI: 10.1016/j.nupar.2024.05.003

Objectives

To examine the relationship between the energy-adjusted dietary inflammatory index (E-DII) and nutritional status, anthropometric measurements, subjective global evaluations (SGA) and biochemical parameters of chronic kidney disease patients.

Methods

Cross-sectional analyses were performed on data collected from individuals.

Participants/setting

Participants included 119 adults aged 19 years and older, who had data from at least three days of valid 24-hour dietary recall data. Main outcome measures nutritional status, anthropometric measurements, SGA and biochemical parameters were collected. Statistical analyses performed Mann–Whitney U test, ANOVA, Kruskal–Wallis and ANCOVA test was used.

Results

It was determined that 79.8% of the patients were well-nourished, 19.3% had moderate malnutrition, and 0.9% had severe malnutrition. The patients with severe malnutrition was in the last quartile. It was determined that macronutrients and all vitamin and mineral intakes decreased in the last quartile values compared to the first quartile values (P < 0.05). After adjustment for age, sex, energy intake and glomerular filtration rat, there was a significant differences in triceps skinfold thickness and body fat percentage among the four quartiles. There was an increase in the C reactive protein levels from the first quartile to the third quartile (P < 0.05).

Conclusions

This study shows that E-DII is a good tool for assessing the overall inflammatory potential of diet in chronic kidney disease patients.

目的 研究慢性肾脏病患者的能量调整膳食炎症指数(E-DII)与营养状况、人体测量、主观总体评价(SGA)和生化指标之间的关系。方法 对收集到的个人数据进行横断面分析。收集的主要结果指标包括营养状况、人体测量、SGA 和生化参数。统计分析采用 Mann-Whitney U 检验、方差分析、Kruskal-Wallis 检验和方差分析检验。严重营养不良的患者位于最后四分之一。经测定,与前四分位值相比,后四分位值的常量营养素以及所有维生素和矿物质的摄入量均有所下降(P < 0.05)。在对年龄、性别、能量摄入量和肾小球滤过率进行调整后,四个四分位数之间的肱三头肌皮褶厚度和体脂率存在显著差异。结论这项研究表明,E-DII 是评估慢性肾病患者饮食整体炎症潜力的良好工具。
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引用次数: 0
Effect of omega-3 fatty acids supplementation on inflammatory markers following exercise-induced muscle damage: Systematic review and meta-analysis of randomized controlled trials 补充欧米伽-3 脂肪酸对运动诱发肌肉损伤后炎症指标的影响:随机对照试验的系统回顾和荟萃分析
IF 0.5 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-09 DOI: 10.1016/j.nupar.2024.04.006

Background

Omega-3 fatty acids supplementation may protect against exercise-induced muscle damage (EIMD) through its anti-inflammatory properties. The purpose of the present meta-analysis was to evaluate the effects of omega-3 fatty acid supplementation on inflammatory markers following EIMD in trained and untrained individuals.

Methods

Medline, Scopus, and Google Scholar databases were systematically searched up to April 2023. The Cochrane Collaboration tool was used to assess the risk of bias and evaluate the quality of the studies.

Results

Omega-3 supplementation significantly reduced interleukin (IL) 6, tumor necrosis factor (TNF)-ɑ, and C-reactive protein (CRP) concentrations.

Conclusion

The current meta-analysis indicated the efficacy of omega-3 in reducing the serum levels of inflammatory markers in healthy individuals, overall, and in subgroup analysis. Thus, omega-3 may be a priority EIMD recovery agent for interventions.

背景补充欧米伽-3 脂肪酸可通过其抗炎特性防止运动诱发的肌肉损伤(EIMD)。本荟萃分析旨在评估补充欧米伽-3 脂肪酸对受过训练和未受过训练的人发生 EIMD 后炎症指标的影响。结果补充欧米伽-3能显著降低白细胞介素(IL)6、肿瘤坏死因子(TNF)-ɑ和C反应蛋白(CRP)的浓度。结论目前的荟萃分析表明,欧米伽-3能有效降低健康人血清中炎症标志物的水平,无论是总体还是亚组分析。因此,欧米伽-3 可能是一种优先干预的 EIMD 恢复剂。
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引用次数: 0
Dietary flavonols intake does not differ throughout a year 膳食中黄酮醇的摄入量全年无差异
IF 0.5 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-09 DOI: 10.1016/j.nupar.2024.05.002

Flavonols got particular attention in the last few years. We hypothesized that the seasonal changes in the availability of their sources do not impact the general flavonols intake. Forty volunteers were enrolled in the study. The 3-day food interviews were performed in 3-month intervals for one year and compared with the FFQ dedicated to the yearlong assessment of flavonols intake. The analysis did not show significant differences for quercetin, kaempferol, isorhamnetin, and total flavonols throughout the year. Significant differences were observed only for myricetin (P = 0.003). At the same time, the detailed analysis of the categories of the consumed products showed significant differences in the seasonal structure of the intakes of fruits (P = 0.01), vegetables (P = 0.046), herbs and spices (P = 0.002), and tea and coffee (P = 0.01). The analysis of the correlation between the results of the one-year follow-up and the results of the FFQ showed significant correlations for total flavonols (R = 0.55; P = 0.001), kaempferol (R = 0.66; P < 0.001), quercetin (R = 0.48; P = 0.002), isorhamnetin (R = 0.41; P = 0.01), and myricetin (R = 0.49; P = 0.001) intakes. This study showed that despite the fluctuations in the selected product intake, the overall intake of quercetin, kaempferol, isorhamnetin, and total flavonols did not show significant differences throughout the year. The analysis showed good agreement between FFQ dedicated to the yearlong assessment of the flavonols intake and multiple food interviews, which proves the validity of the FFQ.

最近几年,黄酮醇受到了特别关注。我们假设,黄酮醇来源的季节性变化不会影响一般黄酮醇的摄入量。研究招募了 40 名志愿者。在为期一年的时间里,每隔 3 个月进行一次为期 3 天的食物访谈,并与专门用于全年黄酮醇摄入量评估的 FFQ 进行比较。分析结果表明,槲皮素、山奈酚、异鼠李素和总黄酮醇的全年摄入量没有明显差异。只有三尖杉酯素有显著差异(P = 0.003)。同时,对消费产品类别的详细分析显示,水果(P = 0.01)、蔬菜(P = 0.046)、香草和香料(P = 0.002)以及茶和咖啡(P = 0.01)的摄入量在季节结构上存在显著差异。一年随访结果与 FFQ 结果之间的相关性分析表明,总黄酮醇(R = 0.55;P = 0.001)、山柰醇(R = 0.66;P < 0.001)、槲皮素(R = 0.48;P = 0.002)、异鼠李素(R = 0.41;P = 0.01)和杨梅素(R = 0.49;P = 0.001)的摄入量存在显著相关性。这项研究表明,尽管所选产品的摄入量存在波动,但槲皮素、山奈酚、异鼠李素和总黄酮醇的总体摄入量在全年中并没有出现显著差异。分析表明,用于全年黄酮类物质摄入量评估的 FFQ 与多次食物访谈之间具有良好的一致性,这证明了 FFQ 的有效性。
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引用次数: 0
Dénutrition et infections : quels mécanismes ? 营养不良与感染:机制是什么?
IF 0.5 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-08 DOI: 10.1016/j.nupar.2024.06.001

Malnutrition, a major public health issue that characterized by an altered energetic and nutritional balance, is associated with an increase of infectious complications and mortality risk. Indeed, an increase of infectious risk has been reported in malnourished subjects in many studies. Various mechanisms are involved in the increased risk of infections and encompass an altered immune response and disrupted barrier function particularly gut barrier function. In this brief review, we focus on thymic and spleen response in malnourished conditions, as well as on the role of energetic fuels, i.e. amino acids, glucose. The contribution of vitamins and trace-elements is also discussed, as well as the role of gut barrier function.

营养不良是一个重大的公共卫生问题,其特点是能量和营养平衡的改变,与感染并发症和死亡风险的增加有关。事实上,在许多研究中都有关于营养不良的受试者感染风险增加的报道。感染风险的增加涉及多种机制,包括免疫反应的改变和屏障功能的破坏,尤其是肠道屏障功能。在这篇简短的综述中,我们将重点关注营养不良情况下胸腺和脾脏的反应,以及能量燃料(即氨基酸和葡萄糖)的作用。此外,还讨论了维生素和微量元素的作用,以及肠道屏障功能的作用。
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引用次数: 0
Algerian initiative guidelines on hospital nutrition 阿尔及利亚医院营养指南倡议
IF 0.5 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-08 DOI: 10.1016/j.nupar.2024.04.007

Objectives

The aim of this article was to study the quality of hospital-provided nutrition in Algeria, to understand possible deficiencies and weaknesses and then propose appropriate recommendations based on the recommendations of The ESPEN, the AFDN, and the SFNCM guidelines.

Materials and methods

The energetic and nutritional value of served meals throughout the week in four public hospitals in east Algeria was calculated. The menus proposed by the dietician of each hospital were used. Energy and nutrient values for each food item were calculated using “CIQUAL Table, 2016”.

Results

The energy average per day was 9759 ± 1111.6 kJ (2332 kcal), and the macronutrients averages per day were: 106 ± 9.2 g, 65 ± 20.5 g, and 326 ± 39.3 g for proteins, lipids and carbohydrates respectively. Results showed imbalance in macronutrients, severe deficiency in healthy fats and micronutrients. Several types of food are absent or insufficient, or proposed in inaccurate types and quantities in hospital menus. The absence and shortage of some types of food and the inaccuracy of types and quantities were the main reasons for the imbalance of the proposed menus in hospitals. We propose a series of evidence-based recommendations tailored to the Algerian healthcare context especially by offering multiple meal choices, addressing macronutrient proportions, and ensuring that diets are responsive to individual patient needs.

Conclusion

Nutrition approach in the hospitals concerned with the study is to reconsider, taking into account hospital menus and all the factors of reduced food intake, to prevent and treat hospital malnutrition and minimize its clinical and economic outcomes.

本文旨在研究阿尔及利亚医院提供的营养质量,了解可能存在的不足和弱点,然后根据 ESPEN、AFDN 和 SFNCM 指南的建议提出适当的建议。采用的是每家医院营养师建议的菜单。结果每天的平均能量为 9759 ± 1111.6 千焦(2332 千卡),每天的平均宏量营养素为:106 ± 9.2 克、65.5 克、106 ± 9.2 克:蛋白质、脂类和碳水化合物的日平均含量分别为:106 ± 9.2 克、65 ± 20.5 克和 326 ± 39.3 克。结果显示,宏量营养素失衡,健康脂肪和微量营养素严重缺乏。在医院的菜单中,有几种食物缺乏或不足,或提出的种类和数量不准确。一些食物种类的缺失和短缺以及种类和数量的不准确是导致医院建议菜单失衡的主要原因。我们提出了一系列适合阿尔及利亚医疗环境的循证建议,特别是通过提供多种膳食选择、解决宏量营养素比例问题以及确保膳食满足患者的个性化需求。
{"title":"Algerian initiative guidelines on hospital nutrition","authors":"","doi":"10.1016/j.nupar.2024.04.007","DOIUrl":"10.1016/j.nupar.2024.04.007","url":null,"abstract":"<div><h3>Objectives</h3><p>The aim of this article was to study the quality of hospital-provided nutrition in Algeria, to understand possible deficiencies and weaknesses and then propose appropriate recommendations based on the recommendations of The ESPEN, the AFDN, and the SFNCM guidelines.</p></div><div><h3>Materials and methods</h3><p>The energetic and nutritional value of served meals throughout the week in four public hospitals in east Algeria was calculated. The menus proposed by the dietician of each hospital were used. Energy and nutrient values for each food item were calculated using “CIQUAL Table, 2016”.</p></div><div><h3>Results</h3><p>The energy average per day was 9759<!--> <!-->±<!--> <!-->1111.6<!--> <!-->kJ (2332<!--> <!-->kcal), and the macronutrients averages per day were: 106<!--> <!-->±<!--> <!-->9.2<!--> <!-->g, 65<!--> <!-->±<!--> <!-->20.5<!--> <!-->g, and 326<!--> <!-->±<!--> <!-->39.3<!--> <!-->g for proteins, lipids and carbohydrates respectively. Results showed imbalance in macronutrients, severe deficiency in healthy fats and micronutrients. Several types of food are absent or insufficient, or proposed in inaccurate types and quantities in hospital menus. The absence and shortage of some types of food and the inaccuracy of types and quantities were the main reasons for the imbalance of the proposed menus in hospitals. We propose a series of evidence-based recommendations tailored to the Algerian healthcare context especially by offering multiple meal choices, addressing macronutrient proportions, and ensuring that diets are responsive to individual patient needs.</p></div><div><h3>Conclusion</h3><p>Nutrition approach in the hospitals concerned with the study is to reconsider, taking into account hospital menus and all the factors of reduced food intake, to prevent and treat hospital malnutrition and minimize its clinical and economic outcomes.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142086995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of vitamin D supplementation on patients with chronic heart failure: A meta-analysis 维生素 D 补充剂对慢性心力衰竭患者的影响:荟萃分析
IF 0.5 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-08 DOI: 10.1016/j.nupar.2024.05.001

Objective

To systematically evaluate the effect of vitamin D supplementation on cardiac function in patients with chronic heart failure.

Methods

Search multiple databases to find randomized controlled trials of vitamin D for chronic heart failure from the self-built database until September 1, 2023. Meta-analysis was performed using RevMan5.3 and Stata15.0 software.

Results

Eighteen articles were included. Vitamin D supplementation has improved left ventricular ejection fraction [WMD = 3.18%, 95%CI (1.07, 5.3), P < 0.05] and 6-minute walking distance [MD = −11.54, 95%CI (−22,215, −0.871), P < 0.05], has decreased left ventricular end-diastolic diameter [MD = −1.67, 95%CI (−2.88, −0.46), P < 0.05], left ventricular end-diastolic volume [MD = −11.94, 95%CI (−20.59, −3.29), P < 0.05], N-terminal forebrain natriuretic peptide [WMD = −0.7, 95%CI (0.24, 1.16), P < 0.05].

Conclusion

Vitamin D supplementation can improve cardiac function, inhibit ventricular remodeling, and increase exercise endurance inpatients with chronic heart failure.

INPLASY registration number

202440032.

目的系统评估维生素D补充剂对慢性心力衰竭患者心脏功能的影响。方法检索多个数据库,从自建数据库中找到截至2023年9月1日的维生素D治疗慢性心力衰竭的随机对照试验。结果共纳入18篇文章。维生素 D 补充剂改善了左心室射血分数[WMD = 3.18%,95%CI (1.07, 5.3),P <0.05]和 6 分钟步行距离[MD = -11.54,95%CI (-22,215, -0.871, P <0.05]。871), P < 0.05],左心室舒张末期直径[MD = -1.67, 95%CI (-2.88, -0.46), P < 0.05]、左心室舒张末期容积[MD = -11.结论补充维生素 D 可改善慢性心力衰竭患者的心功能、抑制心室重塑并提高运动耐力。
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引用次数: 0
L’éditorial de la présidente de la SNFCM SNFCM 主席的社论
IF 0.5 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-08 DOI: 10.1016/j.nupar.2024.07.001
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引用次数: 0
Dietary inflammatory potential in relation to COVID-19 severity and symptoms among individuals recovered from COVID-19: A cross-sectional study 饮食炎症潜能值与 COVID-19 严重程度和 COVID-19 康复者症状的关系:横断面研究
IF 0.5 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-06 DOI: 10.1016/j.nupar.2024.07.002

Background

Inflammation plays a great role in the pathogenesis of COVID-19 as a life-threatening epidemic. This study was conducted to investigate relationship between dietary inflammatory index (DII) and severity and symptoms of COVID-19.

Methods

In total, 683 patients recovered from COVID-19 were included. Dietary intakes of participants were assessed using a validated 168-item FFQ. Outcomes of interest were including severity of disease, symptoms, hospitalization, hypoxia, need to respiratory support, severe lung infection, disease duration, hospitalization, recovery after hospitalization and respiratory support as well as serum level of CRP and ESR.

Results

Participants at the highest quartile of DII score had higher risk of COVID-19 severity (OR: 1.80; 95% CI: 1.01, 3.20), duration of recovery (OR: 1.74; 95% CI: 1.01, 3.02), hypoxia (OR: 2.04, 95% CI: 1.08–3.83), needs to respiratory support (OR: 3.82; 95% CI: 2.08, 7.03), and long disease duration (OR: 2.63; 95% CI: 1.41, 4.89), and higher levels of CRP and ESR (P-value < 0.001). Moreover, risk of COVID-19 symptoms including dyspnea, cough, fever, chills, weakness, myalgia, chest pain, headache, vertigo, sore throat, nausea and vomiting and anorexia was higher among those patients; but no such an association was found for the risk of hospitalization, severe lung infection, hospital duration, duration of respiratory support, blood pressure, pulse rate and respiratory rate.

Conclusion

We found that high DII was associated with greater risk of severe disease, higher levels of serum inflammatory markers and lower life satisfaction in patients with COVID-19. Further, prospective studies are required to confirm our findings.

背景炎症在COVID-19这一威胁生命的流行病的发病机制中起着重要作用。本研究旨在探讨膳食炎症指数(DII)与 COVID-19 的严重程度和症状之间的关系。方法:共纳入了 683 名 COVID-19 康复者,采用经过验证的 168 项 FFQ 评估参与者的膳食摄入量。研究结果包括疾病严重程度、症状、住院治疗、缺氧、呼吸支持需求、严重肺部感染、病程、住院治疗、住院后恢复情况、呼吸支持以及血清 CRP 和 ESR 水平。80;95% CI:1.01,3.20)、恢复持续时间(OR:1.74;95% CI:1.01,3.02)、缺氧(OR:2.04,95% CI:1.08-3.83)、需要呼吸支持(OR:3.82;95% CI:2.08,7.03)和病程长(OR:2.63;95% CI:1.41,4.89)的风险更高,CRP和ESR水平更高(P值< 0.001)。此外,这些患者出现 COVID-19 症状(包括呼吸困难、咳嗽、发热、寒战、乏力、肌痛、胸痛、头痛、眩晕、咽痛、恶心呕吐和厌食)的风险较高;但在住院风险、严重肺部感染、住院时间、呼吸支持时间、血压、脉搏和呼吸频率方面均未发现这种关联。结论我们发现,高 DII 与 COVID-19 患者更高的严重疾病风险、更高的血清炎症标志物水平和更低的生活满意度相关。需要进一步的前瞻性研究来证实我们的发现。
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引用次数: 0
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Nutrition Clinique et Metabolisme
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