Visible Tracking of Small Molecules of Gases with Fluorescent Donors

Jing Yu, Jie Xu, Siyue Ma, Chao Wang, Qing Miao, Linlin Wang and Guang Chen*, 
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Abstract

Biological gasotransmitters (small molecules of gases) play important roles in signal transduction mechanisms and disease treatments. Although a large number of small-molecule donors have been developed, visualizing the release of small molecules remains challenging. Owing to their unique optical properties, fluorophores have been widely applied in cellular imaging and tracking. Researchers have used various fluorophores to develop small-molecule donors with fluorescent activity for visualizing the release of small molecules and their related therapies. These include fluorophores and their derivatives such as boron-dipyrromethene (BODIPY), coumarin, 1,8-naphthalimide, hemicyanine, porphyrin, rhodamine, and fluorescein. In this review, we summarize the design concepts of functional fluorescent small-molecule donors in terms of different types of fluorophores. Then, we discuss how these donors release small molecules, and the imaging modalities and biomedical applications facilitated by their fluorescent properties. With the systematic discussion of these publications, we hope to provide useful references for the development of more practical, advanced fluorescent small-molecule donors in the future.

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利用荧光供体对气体小分子进行可见光追踪
生物气体递质(小分子气体)在信号转导机制和疾病治疗中发挥着重要作用。尽管已开发出大量小分子供体,但对小分子释放进行可视化仍然具有挑战性。由于其独特的光学特性,荧光团被广泛应用于细胞成像和追踪。研究人员利用各种荧光团开发了具有荧光活性的小分子供体,用于可视化小分子的释放及其相关疗法。这些荧光团及其衍生物包括硼-二吡咯烷酮(BODIPY)、香豆素、1,8-萘二甲酰亚胺、半氰胺、卟啉、罗丹明和荧光素。在这篇综述中,我们从不同类型的荧光团角度总结了功能性荧光小分子供体的设计理念。然后,我们讨论了这些供体如何释放小分子,以及它们的荧光特性所促进的成像模式和生物医学应用。我们希望通过对这些出版物的系统讨论,为将来开发更实用、更先进的荧光小分子供体提供有益的参考。
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来源期刊
Chemical & Biomedical Imaging
Chemical & Biomedical Imaging 化学与生物成像-
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期刊介绍: Chemical & Biomedical Imaging is a peer-reviewed open access journal devoted to the publication of cutting-edge research papers on all aspects of chemical and biomedical imaging. This interdisciplinary field sits at the intersection of chemistry physics biology materials engineering and medicine. The journal aims to bring together researchers from across these disciplines to address cutting-edge challenges of fundamental research and applications.Topics of particular interest include but are not limited to:Imaging of processes and reactionsImaging of nanoscale microscale and mesoscale materialsImaging of biological interactions and interfacesSingle-molecule and cellular imagingWhole-organ and whole-body imagingMolecular imaging probes and contrast agentsBioluminescence chemiluminescence and electrochemiluminescence imagingNanophotonics and imagingChemical tools for new imaging modalitiesChemical and imaging techniques in diagnosis and therapyImaging-guided drug deliveryAI and machine learning assisted imaging
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