The role of ATP-binding cassette transporters in arthropod pesticide toxicity and resistance

IF 5.8 1区农林科学 Q1 BIOLOGY Current opinion in insect science Pub Date : 2024-04-17 DOI:10.1016/j.cois.2024.101200

Dries Amezian , Ralf Nauen , Thomas Van Leeuwen

引用次数: 0

Abstract

Pesticide resistance in arthropods threatens agricultural productivity and the control of vector-borne diseases. The ATP-binding cassette (ABC) transporters have emerged as important factors in the toxicity of synthetic pesticides, as well as for Bacillus thuringiensis insecticidal Cry protein binding. Depending on the localization of expression, both higher and lower expression of ABCs have been linked with pesticide resistance. The recent development of genetic-based approaches such as RNAi and CRISPR/Cas9 gene editing in nonmodel species, has greatly contributed to unveil their functional importance in pesticide toxicity and resistance. Using these tools, we are now poised to further unravel the molecular genetic mechanisms of gene regulation uncovering more elusive regulatory resistance genes.

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ABC 转运体在节肢动物农药毒性和抗药性中的作用。

节肢动物对杀虫剂的抗药性威胁着农业生产力和病媒传播疾病的控制。ATP结合盒（ABC）转运体已成为影响合成杀虫剂毒性以及苏云金芽孢杆菌杀虫隐球菌蛋白结合的重要因素。根据表达的定位，ABC 的高表达和低表达都与农药抗性有关。最近在非模式物种中开发的基于基因的方法（如 RNAi 和 CRISPR/Cas9 基因编辑）大大有助于揭示 ABC 在农药毒性和抗性中的重要功能。利用这些工具，我们现在可以进一步揭示基因调控的分子遗传机制，发现更多难以捉摸的调控抗性基因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in insect science BIOLOGYECOLOGYENTOMOLOGY-ECOLOGY

CiteScore

10.40

自引率

1.90%

发文量

113

期刊介绍： Current Opinion in Insect Science is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up–to–date with the expanding volume of information published in the field of Insect Science. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following 11 areas are covered by Current Opinion in Insect Science. -Ecology -Insect genomics -Global Change Biology -Molecular Physiology (Including Immunity) -Pests and Resistance -Parasites, Parasitoids and Biological Control -Behavioural Ecology -Development and Regulation -Social Insects -Neuroscience -Vectors and Medical and Veterinary Entomology There is also a section that changes every year to reflect hot topics in the field. Section Editors, who are major authorities in their area, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors commission articles from leading scientists on each topic that they have selected and the commissioned authors write short review articles in which they present recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.