{"title":"Sunlight: Time for a Rethink?","authors":"","doi":"10.1016/j.jid.2023.12.027","DOIUrl":null,"url":null,"abstract":"<div><p>UVR is a skin carcinogen, yet no studies link sun exposure to increased all-cause mortality. Epidemiological studies from the United Kingdom and Sweden link sun exposure with reduced all-cause, cardiovascular, and cancer mortality. Vitamin D synthesis is dependent on UVB exposure. Individuals with higher serum levels of vitamin D are healthier in many ways, yet multiple trials of oral vitamin D supplementation show little benefit. Growing evidence shows that sunlight has health benefits through vitamin D–independent pathways, such as photomobilization of nitric oxide from cutaneous stores with reduction in cardiovascular morbidity. Sunlight has important systemic health benefit as well as risks.</p></div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"144 8","pages":"Pages 1724-1732"},"PeriodicalIF":5.7000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022202X2400280X/pdfft?md5=308457036e9f431cdf4538703f6ad2da&pid=1-s2.0-S0022202X2400280X-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Investigative Dermatology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022202X2400280X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/24 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
UVR is a skin carcinogen, yet no studies link sun exposure to increased all-cause mortality. Epidemiological studies from the United Kingdom and Sweden link sun exposure with reduced all-cause, cardiovascular, and cancer mortality. Vitamin D synthesis is dependent on UVB exposure. Individuals with higher serum levels of vitamin D are healthier in many ways, yet multiple trials of oral vitamin D supplementation show little benefit. Growing evidence shows that sunlight has health benefits through vitamin D–independent pathways, such as photomobilization of nitric oxide from cutaneous stores with reduction in cardiovascular morbidity. Sunlight has important systemic health benefit as well as risks.
紫外线辐射是一种皮肤致癌物质,但没有研究表明日晒与全因死亡率增加有关。英国和瑞典的流行病学研究表明,晒太阳可降低全因死亡率、心血管死亡率和癌症死亡率。维生素 D 的合成依赖于紫外线照射。血清中维生素 D 含量较高的人在许多方面都更健康,但多项口服维生素 D 补充剂的试验表明,维生素 D 补充剂的益处不大。越来越多的证据表明,阳光通过与维生素 D 无关的途径对健康有益,例如从皮肤储存中光动一氧化氮,从而降低心血管发病率。阳光对全身健康既有重要益处,也有风险。
期刊介绍:
Journal of Investigative Dermatology (JID) publishes reports describing original research on all aspects of cutaneous biology and skin disease. Topics include biochemistry, biophysics, carcinogenesis, cell regulation, clinical research, development, embryology, epidemiology and other population-based research, extracellular matrix, genetics, immunology, melanocyte biology, microbiology, molecular and cell biology, pathology, percutaneous absorption, pharmacology, photobiology, physiology, skin structure, and wound healing