{"title":"Development and Internal Validation of a Risk Prediction Model for Carotid Atherosclerosis in the Hyperuricemia Population","authors":"Ximisinuer Tusongtuoheti, Guoqing Huang, Y. Mao","doi":"10.2147/VHRM.S445708","DOIUrl":null,"url":null,"abstract":"Purpose The aim of this study was to identify independent risk factors for carotid atherosclerosis (CAS) in a population with hyperuricemia (HUA) and develop a CAS risk prediction model. Patients and Methods This retrospective study included 3579 HUA individuals who underwent health examinations, including carotid ultrasonography, at the Zhenhai Lianhua Hospital in Ningbo, China, in 2020. All participants were randomly assigned to the training and internal validation sets in a 7:3 ratio. Multivariable logistic regression analysis was used to identify independent risk factors associated with CAS. The characteristic variables were screened using the least absolute shrinkage and selection operator combined with 10-fold cross-validation, and the resulting model was visualized by a nomogram. The discriminative ability, calibration, and clinical utility of the risk model were validated using the receiver operating characteristic curve, calibration curve, and decision curve analysis. Results Sex, age, mean red blood cell volume, and fasting blood glucose were identified as independent risk factors for CAS in the HUA population. Age, gamma-glutamyl transpeptidase, serum creatinine, fasting blood glucose, total triiodothyronine, and direct bilirubin, were screened to construct a CAS risk prediction model. In the training and internal validation sets, the risk prediction model showed an excellent discriminative ability with the area under the curve of 0.891 and 0.901, respectively, and a high level of fit. Decision curve analysis results demonstrated that the risk prediction model could be beneficial when the threshold probabilities were 1–87% and 1–100% in the training and internal validation sets, respectively. Conclusion We developed and internally validated a risk prediction model for CAS in a population with HUA, thereby contributing to the CAS early identification.","PeriodicalId":509369,"journal":{"name":"Vascular Health and Risk Management","volume":"274 ","pages":"195 - 205"},"PeriodicalIF":0.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vascular Health and Risk Management","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/VHRM.S445708","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose The aim of this study was to identify independent risk factors for carotid atherosclerosis (CAS) in a population with hyperuricemia (HUA) and develop a CAS risk prediction model. Patients and Methods This retrospective study included 3579 HUA individuals who underwent health examinations, including carotid ultrasonography, at the Zhenhai Lianhua Hospital in Ningbo, China, in 2020. All participants were randomly assigned to the training and internal validation sets in a 7:3 ratio. Multivariable logistic regression analysis was used to identify independent risk factors associated with CAS. The characteristic variables were screened using the least absolute shrinkage and selection operator combined with 10-fold cross-validation, and the resulting model was visualized by a nomogram. The discriminative ability, calibration, and clinical utility of the risk model were validated using the receiver operating characteristic curve, calibration curve, and decision curve analysis. Results Sex, age, mean red blood cell volume, and fasting blood glucose were identified as independent risk factors for CAS in the HUA population. Age, gamma-glutamyl transpeptidase, serum creatinine, fasting blood glucose, total triiodothyronine, and direct bilirubin, were screened to construct a CAS risk prediction model. In the training and internal validation sets, the risk prediction model showed an excellent discriminative ability with the area under the curve of 0.891 and 0.901, respectively, and a high level of fit. Decision curve analysis results demonstrated that the risk prediction model could be beneficial when the threshold probabilities were 1–87% and 1–100% in the training and internal validation sets, respectively. Conclusion We developed and internally validated a risk prediction model for CAS in a population with HUA, thereby contributing to the CAS early identification.
目的 本研究旨在确定高尿酸血症(HUA)人群中颈动脉粥样硬化(CAS)的独立危险因素,并建立 CAS 风险预测模型。患者和方法 该回顾性研究纳入了2020年在中国宁波镇海联华医院接受健康检查(包括颈动脉超声检查)的3579名高尿酸血症患者。所有参与者按 7:3 的比例随机分配到训练集和内部验证集。多变量逻辑回归分析用于确定与 CAS 相关的独立风险因素。使用最小绝对缩减和选择算子结合10倍交叉验证筛选特征变量,并用提名图直观显示得到的模型。使用接收者操作特征曲线、校准曲线和决策曲线分析验证了风险模型的判别能力、校准和临床实用性。结果 在 HUA 群体中,性别、年龄、平均红细胞体积和空腹血糖被确定为 CAS 的独立风险因素。通过筛选年龄、γ-谷氨酰转肽酶、血清肌酐、空腹血糖、总三碘甲状腺原氨酸和直接胆红素,构建了 CAS 风险预测模型。在训练集和内部验证集中,风险预测模型显示出很好的判别能力,曲线下面积分别为 0.891 和 0.901,拟合度很高。决策曲线分析结果表明,当训练集和内部验证集中的阈值概率分别为 1%-87%和 1%-100%时,风险预测模型可发挥有益作用。结论 我们开发并在内部验证了一个针对 HUA 群体的 CAS 风险预测模型,从而有助于 CAS 的早期识别。