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Cerebral Venous Sinus Thrombosis as an Initial Presentation of Nephrotic Syndrome: A Case Report 脑静脉窦血栓是肾病综合征的最初表现:病例报告
Pub Date : 2024-04-01 DOI: 10.2147/VHRM.S458539
Yassir Balla, Abdullahi Hashi, Ahmed Osman, M. Hassan, E. Mutlu
Abstract Cerebral sinovenous thrombosis (CSVT) encompasses a spectrum of disorders involving thrombosis of the cerebral venous system. As shown by previous epidemiological studies, the prevalence of cerebral sinovenous thrombosis is 4–7 cases per million people. Nephrotic syndrome was very rarely associated with thrombosis cerebral veins or sinuses. Hypercoagulability and thrombotic complications in nephrotic syndrome are most commonly seen in deep veins of the lower extremities and renal veins. Our case highlights a unique scenario in which cerebral sinovenous thrombosis was the initial presentation of nephrotic syndrome in a patient that was not an important past medical or surgical problem. The patient was brought to the emergency department with severe headache, vomiting, altered mental status, and generalized body swelling. Laboratory results showed proteinuria, hypoalbuminemia and hyperlipidemia. Non-contrast brain CT demonstrated hemorrhagic venous infarct associated with vasogenic edema. A subsequent brain MR venogram demonstrated occlusion of superior sagittal and right transverse sinuses. She was managed with low molecular weight heparin and intervenous corticosteroids then shifted to rivaroxaban and oral steroids, respectively, which resulted in massive clinical improvement and resolution of thrombus.
摘要 脑静脉血栓形成(CSVT)包括一系列涉及脑静脉系统血栓形成的疾病。以往的流行病学研究表明,脑静脉血栓的发病率为每百万人中 4-7 例。肾病综合征很少与脑静脉或脑窦血栓形成有关。肾病综合征的高凝状态和血栓并发症最常见于下肢深静脉和肾静脉。我们的病例强调了一种独特的情况,即脑窦静脉血栓是肾病综合征的最初表现,而患者既往并无重要的内科或外科问题。患者因剧烈头痛、呕吐、精神状态改变和全身浮肿被送到急诊科。化验结果显示有蛋白尿、低蛋白血症和高脂血症。非对比脑CT显示出血性静脉梗塞伴血管源性水肿。随后的脑磁共振静脉造影显示上矢状窦和右侧横窦闭塞。她接受了低分子量肝素和静脉皮质类固醇治疗,然后分别转为利伐沙班和口服类固醇,结果临床症状大为改善,血栓也被清除。
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引用次数: 0
Echocardiographic Parameters and Complication Profiles Among Adult Patients with Rheumatic Heart Disease at Jimma Medical Center 吉马医疗中心风湿性心脏病成人患者的超声心动图参数和并发症概况
Pub Date : 2024-04-01 DOI: 10.2147/VHRM.S451957
Hiwot Berhanu, Andualem Mossie, S. Morankar, Tadesse Gemechu, E. Tegene
Background Despite the fact that patients with rheumatic heart disease (RHD) need early medical attention and follow-up, most patients in developing countries tend to present with debilitating complications. The objective of this study was to evaluate the echocardiographic features of adult individuals diagnosed with RHD and examine the associated complications among patients who started follow-up at Jimma Medical Center’s (JMC) cardiac follow-up clinic. Methods A prospective cross-sectional study was conducted at JMC between January 5 and April 15, 2023. Echocardiographic patterns were taken by senior cardiologists; socio-demographic variables, anthropometric measurements, and behavioral factors were collected through a structured questioner. Results The study recruited a total of 115 participants, of whom 86 (74.8%) were female and 29 (25.2%) were male. The mean age of the patients was 32.31 (SD± 12.16) years. The mitral valve was affected in 98.26% of cases, while the aortic and tricuspid valve abnormalities were diagnosed in 49.5% and 21.7%, respectively. The most frequent combinations of valve lesions were mitral regurgitation (MR) + mitral stenosis (MS) + aortic regurgitation (AR) (15.7%), followed by MR + AR + TR (8.7%). The occurrence of MR+MS+AR was higher in females (17.4%) compared to males (10.3%), whereas the occurrence of MS+MR was higher in males (24.1%) compared to females (20.9%). Females have a severely reduced ejection fraction compared to males (84.8% vs 15.2%, P = 0.044). Nearly two-thirds (63.5%) of individuals experienced RHD-related complications; the most commonly encountered complications were pulmonary hypertension (26.1%) and atrial fibrillation (19.1%). Conclusion RHD predominantly affects individuals in their active and productive years, particularly females. Most patients have multiple-valve lesions.
背景 尽管风湿性心脏病(RHD)患者需要早期治疗和随访,但发展中国家的大多数患者往往会出现使人衰弱的并发症。本研究旨在评估被诊断为风湿性心脏病的成人患者的超声心动图特征,并检查在吉马医疗中心(JMC)心脏随访门诊开始随访的患者的相关并发症。方法 在 2023 年 1 月 5 日至 4 月 15 日期间,在吉马医疗中心开展了一项前瞻性横断面研究。由资深心脏病专家绘制超声心动图;通过结构化问卷收集社会人口变量、人体测量数据和行为因素。结果 该研究共招募了 115 名参与者,其中 86 名(74.8%)为女性,29 名(25.2%)为男性。患者的平均年龄为 32.31(SD± 12.16)岁。98.26%的病例受二尖瓣影响,49.5%和21.7%的病例被诊断为主动脉瓣和三尖瓣异常。最常见的瓣膜病变组合是二尖瓣反流(MR)+二尖瓣狭窄(MS)+主动脉瓣反流(AR)(15.7%),其次是MR+AR+TR(8.7%)。女性发生 MR+MS+AR 的比例(17.4%)高于男性(10.3%),而男性发生 MS+MR 的比例(24.1%)高于女性(20.9%)。与男性相比,女性的射血分数严重降低(84.8% vs 15.2%,P = 0.044)。近三分之二(63.5%)的患者出现过与 RHD 相关的并发症;最常见的并发症是肺动脉高压(26.1%)和心房颤动(19.1%)。结论 RHD 主要影响活跃期和生产期的人群,尤其是女性。大多数患者有多瓣膜病变。
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引用次数: 0
Association of Handgrip Strength and Cardiovascular Disease Risk Among Middle-Aged Postmenopausal Women: An Analysis of the Korea National Health and Nutrition Examination Survey 2014–2019 绝经后中年女性的手握力与心血管疾病风险的关系:2014-2019年韩国国民健康与营养调查分析
Pub Date : 2024-04-01 DOI: 10.2147/VHRM.S442277
Jinkyung Park, Sooyeon Park
Purpose Handgrip strength is an indicator of overall muscle strength and has been associated with an increased risk of cardiovascular disease. Evidence suggests that menopause is a risk factor for cardiovascular disease in women, and muscle strength decreases progressively after menopause. Despite the prognostic importance of the decline in muscle strength and increased cardiovascular disease risk among postmenopausal women, evidence of their association is limited. This study aimed to investigate the relationship between handgrip strength and cardiovascular disease risk among postmenopausal, middle-aged Korean women. Patients and Methods Using pooled cohort equations, we calculated the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) among postmenopausal women (N = 2019) aged 50–64 years without cardiovascular disease history from the 2014–2019 Korea National Health and Nutrition Examination Survey. Relative grip strength was defined as measured grip strength divided by body mass index. Logistic regression analysis of a complex sampling design was performed to evaluate the association between relative grip strength and a predicted 10-year ASCVD risk ≥7.5%. Results The average handgrip strength was 24.8 kg, and 5.2% of women were considered for sarcopenia (<18 kg). The quartile-stratified relative grip strength was negatively associated with 10-year ASCVD risk (p < 0.001). In the multiple logistic regression analysis, the adjusted odds ratio for the highest relative grip strength quartile was 0.53 (95% confidence interval [CI]: 0.36–0.78), and that of the group who breastfed for more than 12 months was 1.75 (95% CI: 1.36–2.25) for 10-year ASCVD risk. Conclusion Increased handgrip strength may be associated with lower cardiovascular disease risk among middle-aged postmenopausal women in Korea. Our findings provide critical evidence regarding the importance of increasing handgrip strength among postmenopausal, middle-aged women to reduce cardiovascular disease risk. Handgrip strength measurement might be a valuable screening tool for cardiovascular disease prevention.
目的 手握力是整体肌肉力量的一个指标,与心血管疾病风险的增加有关。有证据表明,绝经是女性罹患心血管疾病的一个风险因素,而绝经后肌肉力量会逐渐下降。尽管绝经后妇女肌肉力量的下降和心血管疾病风险的增加在预后方面具有重要意义,但有关它们之间关系的证据却很有限。本研究旨在调查绝经后韩国中年女性的手握力与心血管疾病风险之间的关系。患者和方法 我们使用集合队列方程,计算了2014-2019年韩国国民健康和营养调查中50-64岁无心血管疾病史的绝经后妇女(N = 2019)的10年动脉粥样硬化性心血管疾病(ASCVD)风险。相对握力的定义是测量的握力除以体重指数。对复杂抽样设计进行了逻辑回归分析,以评估相对握力与预测10年ASCVD风险≥7.5%之间的关联。结果 平均握力为 24.8 千克,5.2% 的女性被认为患有肌肉疏松症(<18 千克)。四分位相对握力与 10 年 ASCVD 风险呈负相关(p < 0.001)。在多元逻辑回归分析中,相对握力最高的四分位数与 10 年 ASCVD 风险的调整赔率比为 0.53(95% 置信区间 [CI]:0.36-0.78),而母乳喂养超过 12 个月的组别与 10 年 ASCVD 风险的调整赔率比为 1.75(95% 置信区间 [CI]:1.36-2.25)。结论 在韩国,中年绝经后妇女手握力的增加可能与心血管疾病风险的降低有关。我们的研究结果为绝经后中年女性增加手握力以降低心血管疾病风险的重要性提供了重要证据。手握力测量可能是预防心血管疾病的一种有价值的筛查工具。
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引用次数: 0
Cardiovascular Risk Factors Among First-Degree Relatives of Patients with Premature Cardiovascular Disease in Malta. Baseline Findings from the CRISO Project 马耳他早发性心血管疾病患者一级亲属的心血管风险因素。CRISO项目的基线调查结果
Pub Date : 2024-04-01 DOI: 10.2147/VHRM.S449672
J. Mifsud, Joseph Galea
Purpose A family history of premature atherosclerotic cardiovascular disease (ASCVD) confers a greater risk of developing ASCVD. However, the prevalence of ASCVD risk factors among asymptomatic Maltese adults with parental or fraternal history of premature ASCVD is unknown. The study aimed to evaluate and compare their risk with the general population. Patients and Methods Posters to market the project were distributed in cardiac rehabilitation areas. Patients with premature cardiovascular disease facilitated recruitment by informing their relatives about the project. Medical doctors and cardiac rehabilitation nurses referred first-degree relatives. Posters were put up in community pharmacies, and an explanatory video clip was shared on social media for interested individuals to contact researchers. Those eligible were enrolled in a preventive cardiology lifestyle intervention. Their data were compared with the risk in the general population. Results Many first-degree relatives had a suboptimal risk profile, with 60% (N = 89) having a total cholesterol level of >5.0 mmol/L; 54% having a low-density lipoprotein-cholesterol level of >3 mmol/L; 70.5% being overweight/obese, with 62% having a waist circumference greater than the recommended values; 34.8% having hypertension; 56.2% being inadequately adherent to the Mediterranean diet; 62% being underactive, with 18% being sedentary; and 25.8% being smokers. First-degree relatives had significantly higher proportions of underactive lifestyle (p = 0.00016), high body mass index (>25kg/m2) (p = 0.006), and systolic blood pressure (p = 0.001) than the general population, with 30% having metabolic syndrome. Conclusion This study determined the prevalence of lifestyle, biochemical, physiological, and anthropometric cardiovascular risk factors among asymptomatic first-degree relatives of Maltese patients with premature ASCVD. First-degree relatives had considerable prevalences of an underactive lifestyle, hypertension, and obesity, suggesting better screening and early risk factor intervention are needed to modify their risk of ASCVD.
目的 早发性动脉粥样硬化性心血管疾病(ASCVD)家族史会增加患 ASCVD 的风险。然而,在父母或兄弟有早发性动脉粥样硬化性心血管疾病病史的无症状马耳他成年人中,动脉粥样硬化性心血管疾病风险因素的发生率尚不清楚。本研究旨在评估并比较他们与普通人群的风险。患者和方法 在心脏康复区分发了宣传该项目的海报。早发性心血管疾病患者通过告知其亲属该项目的信息来促进招募工作。医生和心脏康复护士推荐一级亲属。在社区药房张贴海报,并在社交媒体上分享解释性视频短片,以便有兴趣者联系研究人员。符合条件的人参加了预防性心脏病生活方式干预。他们的数据与普通人群的风险进行了比较。结果 许多一级亲属的风险状况不理想,60%(N = 89)的人总胆固醇水平>5.0 mmol/L;54%的人低密度脂蛋白胆固醇水平>3 mmol/L;70.5%的人超重/肥胖,62%的人腰围大于建议值;34.8%的人患有高血压;56.2%的人未充分坚持地中海饮食;62%的人运动不足,18%的人久坐不动;25.8%的人吸烟。一级亲属中生活方式不积极(p = 0.00016)、体重指数高(>25kg/m2)(p = 0.006)和收缩压高(p = 0.001)的比例明显高于普通人群,其中 30% 的人患有代谢综合征。结论 本研究确定了过早出现 ASCVD 的马耳他患者的无症状一级亲属中生活方式、生化、生理和人体测量心血管风险因素的患病率。一级亲属中生活方式不积极、高血压和肥胖的发病率相当高,这表明需要更好地筛查和早期干预风险因素,以降低他们患 ASCVD 的风险。
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引用次数: 0
Development and Internal Validation of a Risk Prediction Model for Carotid Atherosclerosis in the Hyperuricemia Population 高尿酸血症人群颈动脉粥样硬化风险预测模型的开发与内部验证
Pub Date : 2024-04-01 DOI: 10.2147/VHRM.S445708
Ximisinuer Tusongtuoheti, Guoqing Huang, Y. Mao
Purpose The aim of this study was to identify independent risk factors for carotid atherosclerosis (CAS) in a population with hyperuricemia (HUA) and develop a CAS risk prediction model. Patients and Methods This retrospective study included 3579 HUA individuals who underwent health examinations, including carotid ultrasonography, at the Zhenhai Lianhua Hospital in Ningbo, China, in 2020. All participants were randomly assigned to the training and internal validation sets in a 7:3 ratio. Multivariable logistic regression analysis was used to identify independent risk factors associated with CAS. The characteristic variables were screened using the least absolute shrinkage and selection operator combined with 10-fold cross-validation, and the resulting model was visualized by a nomogram. The discriminative ability, calibration, and clinical utility of the risk model were validated using the receiver operating characteristic curve, calibration curve, and decision curve analysis. Results Sex, age, mean red blood cell volume, and fasting blood glucose were identified as independent risk factors for CAS in the HUA population. Age, gamma-glutamyl transpeptidase, serum creatinine, fasting blood glucose, total triiodothyronine, and direct bilirubin, were screened to construct a CAS risk prediction model. In the training and internal validation sets, the risk prediction model showed an excellent discriminative ability with the area under the curve of 0.891 and 0.901, respectively, and a high level of fit. Decision curve analysis results demonstrated that the risk prediction model could be beneficial when the threshold probabilities were 1–87% and 1–100% in the training and internal validation sets, respectively. Conclusion We developed and internally validated a risk prediction model for CAS in a population with HUA, thereby contributing to the CAS early identification.
目的 本研究旨在确定高尿酸血症(HUA)人群中颈动脉粥样硬化(CAS)的独立危险因素,并建立 CAS 风险预测模型。患者和方法 该回顾性研究纳入了2020年在中国宁波镇海联华医院接受健康检查(包括颈动脉超声检查)的3579名高尿酸血症患者。所有参与者按 7:3 的比例随机分配到训练集和内部验证集。多变量逻辑回归分析用于确定与 CAS 相关的独立风险因素。使用最小绝对缩减和选择算子结合10倍交叉验证筛选特征变量,并用提名图直观显示得到的模型。使用接收者操作特征曲线、校准曲线和决策曲线分析验证了风险模型的判别能力、校准和临床实用性。结果 在 HUA 群体中,性别、年龄、平均红细胞体积和空腹血糖被确定为 CAS 的独立风险因素。通过筛选年龄、γ-谷氨酰转肽酶、血清肌酐、空腹血糖、总三碘甲状腺原氨酸和直接胆红素,构建了 CAS 风险预测模型。在训练集和内部验证集中,风险预测模型显示出很好的判别能力,曲线下面积分别为 0.891 和 0.901,拟合度很高。决策曲线分析结果表明,当训练集和内部验证集中的阈值概率分别为 1%-87%和 1%-100%时,风险预测模型可发挥有益作用。结论 我们开发并在内部验证了一个针对 HUA 群体的 CAS 风险预测模型,从而有助于 CAS 的早期识别。
{"title":"Development and Internal Validation of a Risk Prediction Model for Carotid Atherosclerosis in the Hyperuricemia Population","authors":"Ximisinuer Tusongtuoheti, Guoqing Huang, Y. Mao","doi":"10.2147/VHRM.S445708","DOIUrl":"https://doi.org/10.2147/VHRM.S445708","url":null,"abstract":"Purpose The aim of this study was to identify independent risk factors for carotid atherosclerosis (CAS) in a population with hyperuricemia (HUA) and develop a CAS risk prediction model. Patients and Methods This retrospective study included 3579 HUA individuals who underwent health examinations, including carotid ultrasonography, at the Zhenhai Lianhua Hospital in Ningbo, China, in 2020. All participants were randomly assigned to the training and internal validation sets in a 7:3 ratio. Multivariable logistic regression analysis was used to identify independent risk factors associated with CAS. The characteristic variables were screened using the least absolute shrinkage and selection operator combined with 10-fold cross-validation, and the resulting model was visualized by a nomogram. The discriminative ability, calibration, and clinical utility of the risk model were validated using the receiver operating characteristic curve, calibration curve, and decision curve analysis. Results Sex, age, mean red blood cell volume, and fasting blood glucose were identified as independent risk factors for CAS in the HUA population. Age, gamma-glutamyl transpeptidase, serum creatinine, fasting blood glucose, total triiodothyronine, and direct bilirubin, were screened to construct a CAS risk prediction model. In the training and internal validation sets, the risk prediction model showed an excellent discriminative ability with the area under the curve of 0.891 and 0.901, respectively, and a high level of fit. Decision curve analysis results demonstrated that the risk prediction model could be beneficial when the threshold probabilities were 1–87% and 1–100% in the training and internal validation sets, respectively. Conclusion We developed and internally validated a risk prediction model for CAS in a population with HUA, thereby contributing to the CAS early identification.","PeriodicalId":509369,"journal":{"name":"Vascular Health and Risk Management","volume":"274 ","pages":"195 - 205"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective Cohort Angiographic Analysis of Vertebral Artery Dominance, Stenosis Patterns, and Demographic Correlations 椎动脉优势、狭窄模式和人口统计学相关性的回顾性队列血管造影分析
Pub Date : 2024-04-01 DOI: 10.2147/vhrm.s453352
Izzeddin Qtaish, Mohammad Ayasrah, Noat Qtaish
Background: Differences in dominance and stenosis in the complex vertebral artery (VA) network pose challenges in diagnosing and treating cerebrovascular diseases crucial for brain nutrition. This research examines these intricacies, highlighting the importance of detailed diagnosis and treatment methods. Objective: To analyze the prevalence of the dominant VA, evaluate the influence of gender and age on steno-occlusion, and explore the correlation between the dominant VA and stenosed VA segments. Methods: A retrospective study of 249 angiograms from patients with VA stenosed at King Abdullah University Hospital between August 2019 and December 2022. The patients presenting symptoms of vertigo, migraines, headaches, or transient ischemic attacks (TIA) were included, 182 cases were classified based on VA dominance and stenosis severity. The data were analyzed using IBM SPSS 27. Results: Out of the 182 participants, 64.8% were male, with an average age of 61.3 years and 35.2% were female. The prevalence of stenosis was distributed as follows: 26.4% mild, 44.0% moderate, and 29.7% severe. Statistically significant correlations were observed between hypertension, smoking, hyperlipidemia, and the degree of stenosis (p < 0.05), but not with diabetes. The prevalence of left vertebral artery (VA) dominance was found to be 41.1%. Additionally, there was no gender connection observed in the distribution of steno-occlusion (p = 0.434). There is no notable correlation between the degree of stenosis and the dominant vertebral artery (p > 0.05). Conclusion: Angiographic findings reveal the complex relationship between the dominance of the VA, patterns of stenosis, and demographic factors. Individuals with a dominant VA had a greater likelihood of developing stenosis on the opposite non-dominant side. The high occurrence of severe stenosis highlights the need for tailored diagnostic and treatment approaches. Understanding vertebral stenosis as a multifaceted interaction of demographic, lifestyle, and anatomical variables is essential for enhancing treatment strategies.
背景:复杂的椎动脉(VA)网络中支配和狭窄程度的差异给诊断和治疗对大脑营养至关重要的脑血管疾病带来了挑战。本研究探讨了这些错综复杂的问题,强调了详细诊断和治疗方法的重要性。研究目的分析优势 VA 的患病率,评估性别和年龄对狭窄闭塞的影响,并探讨优势 VA 与狭窄 VA 节段之间的相关性。方法:回顾性研究对2019年8月至2022年12月期间阿卜杜拉国王大学医院249例VA狭窄患者的血管造影进行回顾性研究。研究纳入了出现眩晕、偏头痛、头痛或短暂性脑缺血发作(TIA)症状的患者,并根据 VA 优势和狭窄严重程度对 182 例患者进行了分类。数据使用 IBM SPSS 27 进行分析。结果在 182 名参与者中,64.8% 为男性,平均年龄为 61.3 岁,35.2% 为女性。血管狭窄的发病率分布如下:26.4%为轻度,44.0%为中度,29.7%为重度。高血压、吸烟、高脂血症与椎动脉狭窄程度之间存在统计学意义上的相关性(P < 0.05),但与糖尿病之间不存在相关性。左侧椎动脉(VA)优势的发病率为 41.1%。此外,在狭窄闭塞的分布上没有观察到性别差异(P = 0.434)。狭窄程度与优势椎动脉之间没有明显的相关性(P > 0.05)。结论血管造影结果揭示了优势椎动脉、狭窄模式和人口学因素之间的复杂关系。有优势椎动脉的人在非优势椎动脉的对侧发生狭窄的可能性更大。严重椎管狭窄的高发生率凸显了采取有针对性的诊断和治疗方法的必要性。了解椎管狭窄是人口、生活方式和解剖学变量的多方面相互作用,对于改进治疗策略至关重要。
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引用次数: 0
Health Literacy, Self-Care Behaviors, and Biochemical Parameters Among Hypertensive Patients with Renal Complications in the Tai Lue Ethnic Community of Thailand 泰国泰卢族社区肾脏并发症高血压患者的健康素养、自我护理行为和生化指标
Pub Date : 2024-03-04 DOI: 10.2147/VHRM.S450775
Nittaya Sriprachot, Katekaew Seangpraw, P. Ong-Artborirak
Purpose Hypertension (HT) can cause renal complications or deterioration of kidney function. HT management is very important because it reduces the severity of illnesses. This study aimed to investigate the relationship between health literacy (HL), self-care behaviors (SCB), and biochemical parameters in hypertensive patients with renal complications. Methods A cross-sectional study of 405 hypertensive patients with renal complications among Tai Lue people living in Thailand was conducted using simple random sampling. Face-to-face interviews with questionnaires were used to collect information. Blood pressure (BP) and biochemical parameters, such as fasting blood sugar (FBS) and estimated glomerular filtration rate (eGFR), were measured. Results The participants’ mean age was 68.3 years. A significant correlation was found between HL score, SCB score, systolic BP (SBP), diastolic BP (DBP), FBS, and eGFR (p<0.01). Multiple linear regression revealed that eating salty foods was a risk factor for SBP in males and for SBP and DBP in females. Body mass index (BMI) (B = 0.54), sweet food consumption (B = 13.90), and SCB score (B = −0.29) were significantly associated with FBS level (R2 = 17.8%, p<0.05). Employment (B = 2.55), eating bland food (B = 4.07), receiving information from family (B = 3.53), SCB (B= 0.31), and age (B = −0.51) were all significant factors for eGFR (R2 = 35.0%, p<0.05). Conclusion HL and SCB levels were associated with the health of hypertensive patients with renal complications in the Tai Lue ethnic community. The significance of organizing health education programs is to emphasize increasing HL to lead to self-care decisions and reduce complications in patients, resulting in improved SCB and quality of life in the future.
目的 高血压(HT)可导致肾脏并发症或肾功能恶化。高血压管理非常重要,因为它能减轻疾病的严重程度。本研究旨在调查肾脏并发症高血压患者的健康素养(HL)、自我保健行为(SCB)和生化指标之间的关系。方法 采用简单随机抽样方法,对生活在泰国的 405 名患有肾脏并发症的高血压患者进行了横断面研究。研究采用面对面访谈和问卷调查的方式收集信息。测量了血压(BP)和生化指标,如空腹血糖(FBS)和估计肾小球滤过率(eGFR)。结果 参与者的平均年龄为 68.3 岁。HL 评分、SCB 评分、收缩压(SBP)、舒张压(DBP)、FBS 和 eGFR 之间存在明显相关性(P<0.01)。多元线性回归显示,吃咸是男性 SBP 的危险因素,也是女性 SBP 和 DBP 的危险因素。体重指数(BMI)(B = 0.54)、甜食摄入量(B = 13.90)和 SCB 评分(B = -0.29)与 FBS 水平显著相关(R2 = 17.8%,p<0.05)。就业(B = 2.55)、进食平淡食物(B = 4.07)、从家人处获得信息(B = 3.53)、SCB(B = 0.31)和年龄(B = -0.51)都是影响 eGFR 的重要因素(R2 = 35.0%,P<0.05)。结论 HL 和 SCB 水平与泰族社区肾脏并发症高血压患者的健康相关。组织健康教育计划的意义在于强调提高 HL,使患者做出自我护理决定并减少并发症,从而改善 SCB 和未来的生活质量。
{"title":"Health Literacy, Self-Care Behaviors, and Biochemical Parameters Among Hypertensive Patients with Renal Complications in the Tai Lue Ethnic Community of Thailand","authors":"Nittaya Sriprachot, Katekaew Seangpraw, P. Ong-Artborirak","doi":"10.2147/VHRM.S450775","DOIUrl":"https://doi.org/10.2147/VHRM.S450775","url":null,"abstract":"Purpose Hypertension (HT) can cause renal complications or deterioration of kidney function. HT management is very important because it reduces the severity of illnesses. This study aimed to investigate the relationship between health literacy (HL), self-care behaviors (SCB), and biochemical parameters in hypertensive patients with renal complications. Methods A cross-sectional study of 405 hypertensive patients with renal complications among Tai Lue people living in Thailand was conducted using simple random sampling. Face-to-face interviews with questionnaires were used to collect information. Blood pressure (BP) and biochemical parameters, such as fasting blood sugar (FBS) and estimated glomerular filtration rate (eGFR), were measured. Results The participants’ mean age was 68.3 years. A significant correlation was found between HL score, SCB score, systolic BP (SBP), diastolic BP (DBP), FBS, and eGFR (p<0.01). Multiple linear regression revealed that eating salty foods was a risk factor for SBP in males and for SBP and DBP in females. Body mass index (BMI) (B = 0.54), sweet food consumption (B = 13.90), and SCB score (B = −0.29) were significantly associated with FBS level (R2 = 17.8%, p<0.05). Employment (B = 2.55), eating bland food (B = 4.07), receiving information from family (B = 3.53), SCB (B= 0.31), and age (B = −0.51) were all significant factors for eGFR (R2 = 35.0%, p<0.05). Conclusion HL and SCB levels were associated with the health of hypertensive patients with renal complications in the Tai Lue ethnic community. The significance of organizing health education programs is to emphasize increasing HL to lead to self-care decisions and reduce complications in patients, resulting in improved SCB and quality of life in the future.","PeriodicalId":509369,"journal":{"name":"Vascular Health and Risk Management","volume":"80 1","pages":"97 - 107"},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140080051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Correlation Between Distribution Location and Vulnerability of Carotid Plaque in Patients with Transient Ischemic Attack 评估短暂性脑缺血发作患者颈动脉斑块分布位置与易损性之间的相关性
Pub Date : 2024-03-04 DOI: 10.2147/VHRM.S447418
Yinan Zhao, Yan Gu, Ying Liu, Zhongping Guo
Purpose To analyze the relationship among distribution location, characteristics, and vulnerability of carotid plaque using CTA and provide more information on the risk factors of carotid atherosclerotic plaque. Patients and Methods We retrospectively analyzed the CTA images of the head and neck of 93 patients with carotid atherosclerosis. Atherosclerosis was developed in 148 carotid arteries. The plaques were divided into a high-risk plaque group and a low-risk plaque group according to whether the plaques had high-risk characteristics. The maximum cross-sectional area of carotid artery bifurcation plaque on the axial image was selected, and the cross-sectional lumen was equally divided into four 90-degree sectors, ventral side wall, dorsal side wall, inner side wall, and outer side wall. The differences in the characteristics and distribution locations of the plaques in the two groups were analyzed. The characteristic parameters of the cross-sectional plaques at the bifurcation of the carotid artery. The logistic regression analysis was used to further analyze the risk factors associated with plaque vulnerability. Results Among 148 carotid arteries,80 were classified as high-risk and 68 as low-risk groups. There were significant differences between the two groups concerning the thickness, length, maximum cross-sectional area, burden, and cross-sectional distribution of the plaques (P < 0.05). The plaque distribution on the dorsal side wall of the carotid bifurcation was higher in the high-risk group than that in the low-risk group (P < 0.05), dorsal side wall plaque-independent risk factors for the development of vulnerability of plaques in transient ischemic attack (TIA) patients (95% CI:1.522~6.991, P<0.05). Conclusion High-risk plaques tend to occur on the dorsal side wall of the carotid bifurcation, whereas low-risk plaques tend to occur on the outer side wall of the carotid bifurcation.
目的 利用 CTA 分析颈动脉斑块的分布位置、特征和易损性之间的关系,并提供有关颈动脉粥样硬化斑块危险因素的更多信息。患者和方法 我们回顾性分析了 93 名颈动脉粥样硬化患者的头颈部 CTA 图像。动脉粥样硬化发生在 148 条颈动脉中。根据斑块是否具有高风险特征,将斑块分为高风险斑块组和低风险斑块组。选取轴向图像上颈动脉分叉斑块的最大横截面积,将横截面管腔平均分为腹侧壁、背侧壁、内侧壁和外侧壁四个90度扇形。分析两组斑块特征和分布位置的差异。颈动脉分叉处横截面斑块的特征参数。采用逻辑回归分析进一步分析与斑块易损性相关的危险因素。结果 在148条颈动脉中,80条被划分为高危组,68条被划分为低危组。两组间斑块的厚度、长度、最大横截面积、负荷和横截面分布均有明显差异(P < 0.05)。高危组颈动脉分叉处背侧壁的斑块分布高于低危组(P<0.05),背侧壁斑块是短暂性脑缺血发作(TIA)患者斑块易损性发生的独立危险因素(95% CI:1.522~6.991,P<0.05)。结论 高风险斑块多发生在颈动脉分叉的背侧壁,而低风险斑块多发生在颈动脉分叉的外侧壁。
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引用次数: 0
A Combined Measure of the Triglyceride Glucose Index and Trimethylamine N-Oxide in Risk Stratification of ST-Segment Elevation Myocardial Infarction Patients with High-Risk Plaque Features Defined by Optical Coherence Tomography: A Substudy of the OCTAMI Registry Study 在对具有光学相干断层扫描确定的高危斑块特征的 ST 段抬高心肌梗死患者进行风险分级时综合测量甘油三酯葡萄糖指数和三甲胺 N-氧化物:OCTAMI注册研究的一项子研究
Pub Date : 2024-03-01 DOI: 10.2147/VHRM.S443742
Xiaoxiao Zhao, Hanjun Zhao, Runzhen Chen, Jiannan Li, Jinying Zhou, Nan Li, S. Yan, Chen Liu, P. Zhou, Yi Chen, Li Song, Hongbing Yan
Background and Aim An elevated triglyceride-glucose (TyG) level is associated with increased risk of mortality in patients with CAD. Trimethylamine N-oxide (TMAO) has mechanistic links to atherosclerotic coronary artery disease (CAD) pathogenesis and is correlated with adverse outcomes. However, the incremental prognostic value of TMAO and TyG in the cohort of optical coherence tomography (OCT)-defined high-risk ST-segment elevation myocardial infarction (STEMI) patients is unknown. Methods We studied 274 consecutive aged ≥18 years patients with evidence of STEMI and detected on pre-intervention OCT imaging of culprit lesions between March 2017 and March 2019. Outcomes There were 22 (22.68%), 27 (27.84%), 26 (26.80%), and 22 (22.68%) patients in groups A-D, respectively. The baseline characteristics according to the level of TMAO and TyG showed that patients with higher level in both indicators were more likely to have higher triglycerides (p < 0.001), fasting glucose (p < 0.001) and higher incidence of diabetes (p = 0.008). The group with TMAO > median and TyG ≤ median was associated with higher rates of MACEs significantly (p = 0.009) in fully adjusted analyses. During a median follow-up of 2.027 years, 20 (20.6%) patients experienced MACEs. To evaluate the diagnostic value of the TyG index combined with TMAO, the area under the receiver operating characteristic curve for predicting MACEs after full adjustment was 0.815 (95% confidence interval, 0.723–0.887; sensitivity, 85.00%; specificity, 72.73%; cut-off level, 0.577). Among the group of patients with TMAO > median and TyG ≤ median, there was a significantly higher incidence of MACEs (p=0.033). A similar tendency was found in the cohort with hyperlipidemia (p=0.016) and diabetes mellitus (p=0.036). Conclusion This study demonstrated the usefulness of combined measures of the TyG index and TMAO in enhancing risk stratification in STEMI patients with OCT-defined high-risk plaque characteristics. Trial Registration This study was registered at ClinicalTrials.gov as NCT03593928.
背景和目的 甘油三酯-葡萄糖(TyG)水平升高与 CAD 患者死亡风险增加有关。三甲胺 N-氧化物(TMAO)与动脉粥样硬化性冠状动脉疾病(CAD)的发病机制有关,并与不良预后相关。然而,在光学相干断层扫描(OCT)定义的高风险 ST 段抬高型心肌梗死(STEMI)患者群中,TMAO 和 TyG 的增量预后价值尚不清楚。方法 我们对 2017 年 3 月至 2019 年 3 月期间连续 274 名年龄≥18 岁、有 STEMI 证据且在干预前 OCT 成像中检测到罪魁祸首病灶的患者进行了研究。结果 A-D组患者分别有22人(22.68%)、27人(27.84%)、26人(26.80%)和22人(22.68%)。TMAO和TyG水平的基线特征显示,这两项指标水平越高的患者,甘油三酯(P < 0.001)、空腹血糖(P < 0.001)和糖尿病发病率(P = 0.008)越高。在完全调整分析中,TMAO>中位数和TyG≤中位数组的MACE发生率明显更高(p = 0.009)。在中位随访 2.027 年期间,20 名(20.6%)患者发生了 MACE。为评估TyG指数与TMAO相结合的诊断价值,经全面调整后,预测MACE的接收者操作特征曲线下面积为0.815(95%置信区间,0.723-0.887;灵敏度,85.00%;特异性,72.73%;临界值,0.577)。在 TMAO > 中位数和 TyG ≤ 中位数的患者组中,MACE 的发生率明显更高(P=0.033)。在患有高脂血症(p=0.016)和糖尿病(p=0.036)的人群中也发现了类似的趋势。结论 该研究表明,TyG 指数和 TMAO 的联合测量有助于加强对具有 OCT 定义的高风险斑块特征的 STEMI 患者的风险分层。试验注册 本研究在 ClinicalTrials.gov 注册为 NCT03593928。
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引用次数: 0
Exploring Myocardial Infarction Knowledge, Attitudes, and Practice Among Mogadishu’s Somali Residents 探究摩加迪沙索马里居民对心肌梗死的认识、态度和做法
Pub Date : 2024-01-01 DOI: 10.2147/VHRM.S448220
Mohamed Hassan, Said Ahmed, Mohamed Hassan, M. Mohamud, A. Abdi
Introduction Myocardial infarction and cardiovascular disease are significant global health issues, particularly in Somalia. The Somali population faces challenges due to armed conflict, limited education, and underdeveloped healthcare infrastructure. Cardiovascular risk factors like diabetes, hypertension, and obesity are prevalent, and Somali people face increased susceptibility. Methods This study examined Somalia residents’ perceptions, attitudes, and behaviors towards myocardial infarction using a cross-sectional paper-based questionnaire. The sample consisted of 313 urban residents in Mogadishu, aged 20 and above. The questionnaire was written in Somali and was designed for the demographic. Knowledge, attitude, and practice scores were categorized into two groups, with associations between knowledge, attitude, and practice with sociodemographic and health characteristics assessed using Logistic Regression. Results This study analyzed data from A random sample of participants who arrived at the hospital for various reasons regarding their perceptions, attitudes, and responses towards myocardial infarction. The mean age was 42 ±19 years, with 54% being male and 46% female. Hypertension was the most common comorbidity, followed by dyslipidemia and diabetes. Over half of the respondents had no formal education, and only 3.8% had a smoking history. About 5.7% had a previous history of myocardial infarction. The mean knowledge score was 11.07 ± 0.697, with 53.35% of respondents not knowing enough about myocardial infarction. The majority of the patients showed a favorable attitude, but only a slight majority could recognize symptoms of myocardial infarction. The majority of the patients had inadequate practice and behavior, with 53.6% not practicing regularly or engaging in sports. Conclusion The research highlights gaps in Mogadishu’s Somali community’s knowledge and practices regarding myocardial infarction. It emphasizes the need for health education, primary care, and community involvement to improve cardiovascular health awareness and reduce MI incidence.
导言 心肌梗塞和心血管疾病是全球重大的健康问题,在索马里尤其如此。由于武装冲突、有限的教育和欠发达的医疗基础设施,索马里人口面临着各种挑战。糖尿病、高血压和肥胖等心血管风险因素普遍存在,索马里人面临着更大的易感性。方法 本研究使用横断面纸质问卷调查了索马里居民对心肌梗死的认知、态度和行为。样本包括摩加迪沙 313 名 20 岁及以上的城市居民。问卷用索马里语撰写,专为人口统计学设计。知识、态度和实践得分被分为两组,知识、态度和实践与社会人口学和健康特征之间的关联采用逻辑回归法进行评估。结果 本研究分析了因各种原因到医院就诊的随机抽样参与者对心肌梗死的认知、态度和反应的数据。参与者的平均年龄为 42 ± 19 岁,其中 54% 为男性,46% 为女性。高血压是最常见的合并症,其次是血脂异常和糖尿病。超过一半的受访者没有受过正规教育,只有 3.8% 的人有吸烟史。约 5.7% 的人曾有过心肌梗死病史。平均知识得分为 11.07 ± 0.697,53.35% 的受访者对心肌梗死了解不够。大多数患者表现出良好的态度,但只有少部分患者能识别心肌梗死的症状。大多数患者的练习和行为不足,53.6%的患者没有定期练习或参加体育运动。结论 该研究强调了摩加迪沙索马里社区在心肌梗死知识和实践方面存在的差距。它强调了健康教育、初级保健和社区参与的必要性,以提高心血管健康意识并降低心肌梗死的发病率。
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Vascular Health and Risk Management
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