Biopesticide spinosad: Unraveling ecotoxicological effects on zebrafish, Danio rerio

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Environmental toxicology and pharmacology Pub Date : 2024-04-23 DOI:10.1016/j.etap.2024.104458

Inês Amaral , Sara C. Antunes , Daniela Rebelo , António Paulo Carvalho , Sara Rodrigues

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Abstract

Biopesticides are natural compounds considered more safe and sustainable for the environment. Spinosad (SPI) is a bioinsecticide used in marketed worldwide, to eradicate a variety of pests. This study aimed to assess the impacts of the SPI on the non-target organism zebrafish (Danio rerio). Several concentrations of SPI were tested to evaluate the acute (0.07–1.0 mg/L) and chronic (0.006–0.100 mg/L) ecotoxicological effects. To evaluate sub-individual effects, antioxidant defense, lipid peroxidation, energy sources, and cholinergic biomarkers were quantified. In both exposures, SPI induced significant effects on antioxidant defense indicating oxidative stress, disrupting energy pathways, and exhibiting neurotoxic effects, under environmentally relevant conditions. Integrated Biomarker Response (IBRv2) showed that with increasing SPI concentrations, an increase in impacts on organisms was recorded. This study demonstrates the vulnerability of a non-target organism to SPI, a bioinsecticide considered environmentally safe. Further research is essential to fully understand the implications of spinosad to aquatic biota.

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生物农药 Spinosad：揭示对斑马鱼 Danio rerio 的生态毒理影响。

生物农药是天然化合物，被认为对环境更安全、更可持续。Spinosad（SPI）是一种生物杀虫剂，在全球市场上用于消灭各种害虫。本研究旨在评估 SPI 对非目标生物斑马鱼（Danio rerio）的影响。研究人员测试了多种浓度的 SPI，以评估其急性（0.07-1.0 毫克/升）和慢性（0.006-0.100 毫克/升）生态毒理效应。为了评估亚个体效应，对抗氧化防御、脂质过氧化、能量来源和胆碱能生物标志物进行了量化。在两种暴露条件下，SPI 都对抗氧化防御产生了显著影响，表明在环境相关条件下存在氧化应激、能量途径紊乱和神经毒性效应。综合生物标记反应（IBRv2）显示，随着 SPI 浓度的增加，对生物的影响也随之增加。这项研究表明，非目标生物很容易受到 SPI（一种被认为对环境安全的生物杀虫剂）的影响。要充分了解尖孢霉素对水生生物群的影响，必须开展进一步的研究。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.