Environmental toxicology and pharmacology最新文献

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Exposure to a widely used mito-toxic fungicide negatively affects hemolymph protein and vitellogenin levels in honey bees (Apis mellifera)

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-03-16 DOI: 10.1016/j.etap.2025.104676

Adrian Fisher II , Keerut Chahal , Gloria DeGrandi-Hoffman , Brian H. Smith , Jennifer H. Fewell , Jon F. Harrison

Mito-toxic fungicides used in crop protection negatively affect pollinating insects. The fungicide formulation Pristine® (ai: 25.2 % boscalid, 12.8 % pyraclostrobin) induces precocious foraging, reduced lifespan, impaired homing abilities, and reduced body size at field-relevant concentrations. However, the underlying physiological mechanisms for these outcomes are poorly understood. To assess the hypothesis that Pristine® negatively affects the nutritional status of honey bees, we collected workers from colonies that were fed field-relevant concentrations of Pristine® fungicide. Workers were collected concurrently from two experiments in which colonies were subjected to long- or short-term fungicide exposure. Pristine® exposure significantly reduced hemolymph protein concentration in bees from the long-term but not short-term study, and reduced vitellogenin levels during the short-term summer exposure. These findings suggest that mito-toxic fungicides can negatively affect the nutritional status of honey bee workers inducing detrimental behavioral and health outcomes which ultimately impact colony health and growth patterns.

{"title":"Exposure to a widely used mito-toxic fungicide negatively affects hemolymph protein and vitellogenin levels in honey bees (Apis mellifera)","authors":"Adrian Fisher II , Keerut Chahal , Gloria DeGrandi-Hoffman , Brian H. Smith , Jennifer H. Fewell , Jon F. Harrison","doi":"10.1016/j.etap.2025.104676","DOIUrl":"10.1016/j.etap.2025.104676","url":null,"abstract":"<div><div>Mito-toxic fungicides used in crop protection negatively affect pollinating insects. The fungicide formulation Pristine® (ai: 25.2 % boscalid, 12.8 % pyraclostrobin) induces precocious foraging, reduced lifespan, impaired homing abilities, and reduced body size at field-relevant concentrations. However, the underlying physiological mechanisms for these outcomes are poorly understood. To assess the hypothesis that Pristine® negatively affects the nutritional status of honey bees, we collected workers from colonies that were fed field-relevant concentrations of Pristine® fungicide. Workers were collected concurrently from two experiments in which colonies were subjected to long- or short-term fungicide exposure. Pristine® exposure significantly reduced hemolymph protein concentration in bees from the long-term but not short-term study, and reduced vitellogenin levels during the short-term summer exposure. These findings suggest that mito-toxic fungicides can negatively affect the nutritional status of honey bee workers inducing detrimental behavioral and health outcomes which ultimately impact colony health and growth patterns.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104676"},"PeriodicalIF":4.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dimethylmonothioarsinic acid (DMMTAV) induces NQO1 expression through coordinated activation of NRF2 and AHR pathways

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-03-08 DOI: 10.1016/j.etap.2025.104674

Sara R. El-Mahrouk , Ayman O.S. El-Kadi

Dimethylmonothioarsinic acid (DMMTA^V), a potent toxic metabolite of arsenic, exhibits higher cytotoxicity than other arsenicals. This study investigates its influence on NAD(P)H:quinone oxidoreductase (NQO1) regulation in C57BL/6 mice and Hepa-1c1c7 cells. Mice were administered DMMTA^V (6 mg/kg, IP) with or without TCDD (15 µg/kg, IP), and hepatic and extrahepatic tissues were analyzed for NQO1 expression. In vitro, Hepa-1c1c7 cells were treated with 0–2 µM DMMTA^V in the presence and absence of TCDD (1 nM), and NQO1 levels were assessed over time. Western blot, real-time PCR, and ARE-luciferase assays determined protein and transcriptional regulation. DMMTA^V upregulated NQO1 in liver tissues and induced a time-dependent increase in vitro, peaking at 12 h. It enhanced TCDD-induced NQO1 expression and increased nuclear NRF2 and AHR levels, with peak accumulation at two hours. ARE-luciferase activity confirmed transcriptional activation. These findings reveal DMMTA^V enhances NQO1 primarily via NRF2/AHR pathway activation, providing insight into cellular responses to thioarsenicals.

{"title":"Dimethylmonothioarsinic acid (DMMTAV) induces NQO1 expression through coordinated activation of NRF2 and AHR pathways","authors":"Sara R. El-Mahrouk , Ayman O.S. El-Kadi","doi":"10.1016/j.etap.2025.104674","DOIUrl":"10.1016/j.etap.2025.104674","url":null,"abstract":"<div><div>Dimethylmonothioarsinic acid (DMMTA<sup>V</sup>), a potent toxic metabolite of arsenic, exhibits higher cytotoxicity than other arsenicals. This study investigates its influence on NAD(P)H:quinone oxidoreductase (NQO1) regulation in C57BL/6 mice and Hepa-1c1c7 cells. Mice were administered DMMTA<sup>V</sup> (6 mg/kg, IP) with or without TCDD (15 µg/kg, IP), and hepatic and extrahepatic tissues were analyzed for NQO1 expression. In vitro, Hepa-1c1c7 cells were treated with 0–2 µM DMMTA<sup>V</sup> in the presence and absence of TCDD (1 nM), and NQO1 levels were assessed over time. Western blot, real-time PCR, and ARE-luciferase assays determined protein and transcriptional regulation. DMMTA<sup>V</sup> upregulated NQO1 in liver tissues and induced a time-dependent increase in vitro, peaking at 12 h. It enhanced TCDD-induced NQO1 expression and increased nuclear NRF2 and AHR levels, with peak accumulation at two hours. ARE-luciferase activity confirmed transcriptional activation. These findings reveal DMMTA<sup>V</sup> enhances NQO1 primarily via NRF2/AHR pathway activation, providing insight into cellular responses to thioarsenicals.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104674"},"PeriodicalIF":4.2,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigating pesticide risk on bee pollinators and angiosperm biodiversity in the Ndop wetlands: A conservation approach

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-03-07 DOI: 10.1016/j.etap.2025.104671

Therese Ncheuveu Nkwatoh , Patricia Bi Asanga Fai , Alvine Larissa Meyabeme Elono , Louis Sevitenyi Nkwatoh , Sali Atanga Ndindeng

This study aimed to assess the risk of pesticides on bee pollinators and propose strategies to conserve entomophilous angiosperm species in the Ndop wetlands. Results showed that the applied pesticide doses were often excessive, increasing the exposure toxicity ratios (ETR). Among the pesticides, insecticides posed the highest risk to bee pollinators, with Emamectin benzoate (ETR=591.4) presenting the highest risk, followed by imidacloprid (ETR=517.5), fipronil (ETR=496.4), chlorpyrifos (ETR=240.7), and cypermethrin (ETR=131). Lambda-cyhalothrin (ETR=50.53) posed a possible risk. The study found that imidacloprid, fipronil, and chlorpyrifos posed definite risks through dietary exposure, while Emamectin benzoate, fipronil, and cypermethrin posed risks through direct contact. Approximately 46.03 % of angiosperms are anemophilous while 53 % are entomophilous with bee pollinators facilitating the pollination of nearly 90 % of the entomophilous species. To mitigate pesticide risks and for conservation purposes, farmers should refrain from applying pesticides during blooming and peak pollinator activity times, particularly midday.

{"title":"Mitigating pesticide risk on bee pollinators and angiosperm biodiversity in the Ndop wetlands: A conservation approach","authors":"Therese Ncheuveu Nkwatoh , Patricia Bi Asanga Fai , Alvine Larissa Meyabeme Elono , Louis Sevitenyi Nkwatoh , Sali Atanga Ndindeng","doi":"10.1016/j.etap.2025.104671","DOIUrl":"10.1016/j.etap.2025.104671","url":null,"abstract":"<div><div>This study aimed to assess the risk of pesticides on bee pollinators and propose strategies to conserve entomophilous angiosperm species in the Ndop wetlands. Results showed that the applied pesticide doses were often excessive, increasing the exposure toxicity ratios (ETR). Among the pesticides, insecticides posed the highest risk to bee pollinators, with Emamectin benzoate (ETR=591.4) presenting the highest risk, followed by imidacloprid (ETR=517.5), fipronil (ETR=496.4), chlorpyrifos (ETR=240.7), and cypermethrin (ETR=131). Lambda-cyhalothrin (ETR=50.53) posed a possible risk. The study found that imidacloprid, fipronil, and chlorpyrifos posed definite risks through dietary exposure, while Emamectin benzoate, fipronil, and cypermethrin posed risks through direct contact. Approximately 46.03 % of angiosperms are anemophilous while 53 % are entomophilous with bee pollinators facilitating the pollination of nearly 90 % of the entomophilous species. To mitigate pesticide risks and for conservation purposes, farmers should refrain from applying pesticides during blooming and peak pollinator activity times, particularly midday.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104671"},"PeriodicalIF":4.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the toxicity of gadolinium in freshwater and marine ecosystems: Effects across trophic levels

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-03-06 DOI: 10.1016/j.etap.2025.104673

Camilla Mossotto , Serena Anselmi , Stefania Trevisan , Francesca Provenza , Alessandra Maganza , Alice Gabetti , Giuseppe Esposito , Antonia Concetta Elia , Marino Prearo , Monia Renzi , Paolo Pastorino

Rare Earth Elements, particularly gadolinium (Gd), are increasingly used in industrial and medical applications, leading to their dispersion in aquatic environments. This study examines the ecotoxicological effects of Gd on aquatic organisms across different trophic levels in freshwater and marine ecosystems. Using standardized bioassays, the impact of Gd was assessed on Aliivibrio fischeri, Raphidocelis subcapitata, Phaeodactylum tricornutum, Daphnia magna, and Paracentrotus lividus larvae. Results showed that primary producers exhibited the highest sensitivity, with growth inhibition at low concentrations. In contrast, primary consumers (D. magna and P. lividus) were less affected by Gd, displaying a higher tolerance to its toxic effects even at elevated concentrations. Principal component analysis highlighted distinct responses between freshwater and marine organisms, suggesting a complex relationship between Gd bioavailability and toxicity. Hence, Gd contamination poses ecological risks requiring further research on its environmental impact.

{"title":"Assessing the toxicity of gadolinium in freshwater and marine ecosystems: Effects across trophic levels","authors":"Camilla Mossotto , Serena Anselmi , Stefania Trevisan , Francesca Provenza , Alessandra Maganza , Alice Gabetti , Giuseppe Esposito , Antonia Concetta Elia , Marino Prearo , Monia Renzi , Paolo Pastorino","doi":"10.1016/j.etap.2025.104673","DOIUrl":"10.1016/j.etap.2025.104673","url":null,"abstract":"<div><div>Rare Earth Elements, particularly gadolinium (Gd), are increasingly used in industrial and medical applications, leading to their dispersion in aquatic environments. This study examines the ecotoxicological effects of Gd on aquatic organisms across different trophic levels in freshwater and marine ecosystems. Using standardized bioassays, the impact of Gd was assessed on <em>Aliivibrio fischeri</em>, <em>Raphidocelis subcapitata</em>, <em>Phaeodactylum tricornutum</em>, <em>Daphnia magna</em>, and <em>Paracentrotus lividus</em> larvae. Results showed that primary producers exhibited the highest sensitivity, with growth inhibition at low concentrations. In contrast, primary consumers (<em>D. magna</em> and <em>P. lividus</em>) were less affected by Gd, displaying a higher tolerance to its toxic effects even at elevated concentrations. Principal component analysis highlighted distinct responses between freshwater and marine organisms, suggesting a complex relationship between Gd bioavailability and toxicity. Hence, Gd contamination poses ecological risks requiring further research on its environmental impact.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104673"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of 5-OH-DMT (bufotenine) in the Asian toad Duttyphrynus melanostictus, Hoplobatrachus tigerinus and Haemopis sanguisiga in Madagascar by UHPLC-MS/MS

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-03-06 DOI: 10.1016/j.etap.2025.104672

Christina Ververi , Elisah Rasoanomenjanahary Nahavitatsara , Brigitte Annie Bezandry , Vonimanitra Juliana Rasoma Rahantavololona , Cristina Giacoma , Alberto Salomone

5-hydroxy-N,N-dimethyltryptamine (5-OH-DMT), known as bufotenine, is proven to have psychoactive effects in high concentrations. Duttyphrynus melanostictus, which produces bufotenine, has migrated to the city of Toamasina in Madagascar, thus, the determination bufotenine’s levels in the species’ samples is necessary. This study aimed to quantify bufotenine in eggs, tadpoles and toad’s skin samples of the Duttyphrynus melanostictus as well as in its predator Hoplobatrachus tigerinus and Haemopis sanguisiga. Two extraction protocols were applied depending on the sample type both based on liquid liquid extraction. Spiked calibration samples were prepared at six concentration levels (10–1000 ng/mL), and performance parameters were evaluated: linearity, accuracy (bias%), precision (CV%) and limit of detection. The proposed protocol is simple and quick, and the UHPLC-MS/MS system used exhibited adequate sensitivity. The target analyte was detected in all samples except for the eggs of Duttyphrynus melanostictus, with concentrations increasing in line with the animal’s development.

{"title":"Determination of 5-OH-DMT (bufotenine) in the Asian toad Duttyphrynus melanostictus, Hoplobatrachus tigerinus and Haemopis sanguisiga in Madagascar by UHPLC-MS/MS","authors":"Christina Ververi , Elisah Rasoanomenjanahary Nahavitatsara , Brigitte Annie Bezandry , Vonimanitra Juliana Rasoma Rahantavololona , Cristina Giacoma , Alberto Salomone","doi":"10.1016/j.etap.2025.104672","DOIUrl":"10.1016/j.etap.2025.104672","url":null,"abstract":"<div><div>5-hydroxy-N,N-dimethyltryptamine (5-OH-DMT), known as bufotenine, is proven to have psychoactive effects in high concentrations. <em>Duttyphrynus melanostictus</em>, which produces bufotenine, has migrated to the city of Toamasina in Madagascar, thus, the determination bufotenine’s levels in <em>the species’</em> samples is necessary. This study aimed to quantify bufotenine in eggs, tadpoles and toad’s skin samples of the <em>Duttyphrynus melanostictus</em> as well as in its predator <em>Hoplobatrachus tigerinus</em> and <em>Haemopis sanguisiga</em>. Two extraction protocols were applied depending on the sample type both based on liquid liquid extraction. Spiked calibration samples were prepared at six concentration levels (10–1000 ng/mL), and performance parameters were evaluated: linearity, accuracy (bias%), precision (CV%) and limit of detection. The proposed protocol is simple and quick, and the UHPLC-MS/MS system used exhibited adequate sensitivity. The target analyte was detected in all samples except for the eggs of <em>Duttyphrynus melanostictus</em>, with concentrations increasing in line with the animal’s development.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104672"},"PeriodicalIF":4.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contaminant-driven midgut histological damage in bees and other aculeate Hymenoptera: A quantitative review

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-03-04 DOI: 10.1016/j.etap.2025.104670

Carlo Polidori , Chiara Francesca Trisoglio , Andrea Ferrari , Andrea Romano , Francesco Bonasoro

We present a review about histological sub-lethal effects due to anthropogenic contaminants on the midgut of bees and other aculeate hymenopterans. Contaminant types, damage types, and methodology were extracted and summarized from 74 published articles, and then quantitatively analyzed. We found that the Western honeybee (Apis mellifera) is by far the most widely used model. Contaminants have largely been tested under laboratory conditions, particularly insecticides and fungicides. Tissue-level damage (e.g., degradation of epithelium and of peritrophic membrane) were often detected together with cell-level damage (e.g., cell vacuolisation, karyorrhexis). Descriptive statistics and mixed models suggested that herbicides may cause a specific mix of alterations with an overall lower severity compared with other pesticides, while the combined use of light and electron microscopy seemed to detect more damage types. We claim for efforts to reduce biases in future studies on such histological effects, allowing their clearer use as markers of human activities.

{"title":"Contaminant-driven midgut histological damage in bees and other aculeate Hymenoptera: A quantitative review","authors":"Carlo Polidori , Chiara Francesca Trisoglio , Andrea Ferrari , Andrea Romano , Francesco Bonasoro","doi":"10.1016/j.etap.2025.104670","DOIUrl":"10.1016/j.etap.2025.104670","url":null,"abstract":"<div><div>We present a review about histological sub-lethal effects due to anthropogenic contaminants on the midgut of bees and other aculeate hymenopterans. Contaminant types, damage types, and methodology were extracted and summarized from 74 published articles, and then quantitatively analyzed. We found that the Western honeybee (<em>Apis mellifera</em>) is by far the most widely used model. Contaminants have largely been tested under laboratory conditions, particularly insecticides and fungicides. Tissue-level damage (e.g., degradation of epithelium and of peritrophic membrane) were often detected together with cell-level damage (e.g., cell vacuolisation, karyorrhexis). Descriptive statistics and mixed models suggested that herbicides may cause a specific mix of alterations with an overall lower severity compared with other pesticides, while the combined use of light and electron microscopy seemed to detect more damage types. We claim for efforts to reduce biases in future studies on such histological effects, allowing their clearer use as markers of human activities.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104670"},"PeriodicalIF":4.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexually dimorphic cardiovascular impacts of prenatal exposure to a real-life environmental chemical mixture in adult offspring

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-03-04 DOI: 10.1016/j.etap.2025.104669

Noor Muhammad Khan , Victoria Scott , Mohammad Ghasemzadeh-Hasankolaei , Vasantha Padmanabhan , Arpita Vyas , Neil P. Evans , Michelle Bellingham

Cardiovascular disease (CVD) is a leading cause of death that is sexually dimorphic. This study used an ovine model to investigate whether maternal exposure to an environmental chemical (EC) mixture (biosolids) prior to and throughout pregnancy, affected offspring cardiovascular (CV) structure and function in adulthood. CV function of male and female offspring from ewes grazed on either conventionally fertilised (control, C) or biosolids-treated pasture (B) was assessed. Males exhibited higher blood pressure compared to females with no significant effect of EC exposure. Heart rate variability in females suggested reduced autonomic regulation in the B group. EC-exposed males, but not females, showed significantly increased left ventricular dimensions, end-diastolic and systolic volumes, and cardiac output. The findings indicate sexually dimorphic effects of maternal EC mixture exposure on adult CV structure and function. Further studies are needed to explore the mechanisms and long-term implications of prenatal exposure to ECs on CV health.

{"title":"Sexually dimorphic cardiovascular impacts of prenatal exposure to a real-life environmental chemical mixture in adult offspring","authors":"Noor Muhammad Khan , Victoria Scott , Mohammad Ghasemzadeh-Hasankolaei , Vasantha Padmanabhan , Arpita Vyas , Neil P. Evans , Michelle Bellingham","doi":"10.1016/j.etap.2025.104669","DOIUrl":"10.1016/j.etap.2025.104669","url":null,"abstract":"<div><div>Cardiovascular disease (CVD) is a leading cause of death that is sexually dimorphic. This study used an ovine model to investigate whether maternal exposure to an environmental chemical (EC) mixture (biosolids) prior to and throughout pregnancy, affected offspring cardiovascular (CV) structure and function in adulthood. CV function of male and female offspring from ewes grazed on either conventionally fertilised (control, C) or biosolids-treated pasture (B) was assessed. Males exhibited higher blood pressure compared to females with no significant effect of EC exposure. Heart rate variability in females suggested reduced autonomic regulation in the B group. EC-exposed males, but not females, showed significantly increased left ventricular dimensions, end-diastolic and systolic volumes, and cardiac output. The findings indicate sexually dimorphic effects of maternal EC mixture exposure on adult CV structure and function. Further studies are needed to explore the mechanisms and long-term implications of prenatal exposure to ECs on CV health.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104669"},"PeriodicalIF":4.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary study on the effect of first- and second-hand smoke of heat-not-burn tobacco products on urinary nicotine and cotinine levels and cardiovascular system

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-02-27 DOI: 10.1016/j.etap.2025.104657

Dae-Hyeon Kim , Petros Koutrakis , Youn-Suk Son

Heart rate variability (HRV) of 10 participants was assessed to evaluate the impact of exposure to first- and second-hand smoke from heat-not-burn (HnB) products and conventional cigarettes on cardiovascular health and the autonomic nervous system. The nicotine and cotinine concentrations in the urine of smokers and non-smokers exposed to this smoke were also measured. Nicotine levels in the urine of smokers exposed to HnB products and conventional cigarettes averaged 71.76 and 229.36 ng/ml, respectively. Short-term analyses of HRV in both time- and frequency-domain were performed. There were no significant differences in HRV indicators between both groups at baseline. However, decreases in SDNN, rMSSD, TINN, and pNN50 (%) were observed in smokers exposed to both first- and second-hand smoke from HnB products and conventional cigarettes. No significant trends were noted in non-smokers. The frequency-domain analysis revealed a decrease in low frequency components among smokers.

引用次数: 0

Genetic variation in the INMT gene strongly impacts the production of trimethylsulfonium in humans

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-02-24 DOI: 10.1016/j.etap.2025.104662

Olivia Trummer , Carina Maria Laglstorfer , Christoph W. Haudum , Cornelia Missbrenner , Walter Goessler , Barbara Obermayer-Pietsch , Bassam Lajin

We previously identified the trimethylsulfonium ion (TMS) in human urine and highlighted its potential as a novel H₂S biomarker but observed significant inter-individual variability in its urinary excretion. In this work we investigate the contribution of genetic factors to this variability in a group of European subjects (n = 100) from the BioPersMed cohort. Urinary TMS concentrations displayed two clusters within 5.0–20 nM and 100–400 nM. Genotyping revealed that this clustering is linked to a single nucleotide polymorphism (rs6970396) in the INMT gene, P < 0.001. We found strong contrast in the effects of rs6970396 between TMS and the selenium analogue TMSe which is one of many other detoxification products of the poorly recognized chalcogen-methylation activity of the INMT enzyme. Genetic variability in INMT has wide implications not only for the detoxification of H₂S, both inhaled and naturally produced, but also for that of other volatile sulfur compounds in humans which may serve as substrates including xenobiotics.

{"title":"Genetic variation in the INMT gene strongly impacts the production of trimethylsulfonium in humans","authors":"Olivia Trummer , Carina Maria Laglstorfer , Christoph W. Haudum , Cornelia Missbrenner , Walter Goessler , Barbara Obermayer-Pietsch , Bassam Lajin","doi":"10.1016/j.etap.2025.104662","DOIUrl":"10.1016/j.etap.2025.104662","url":null,"abstract":"<div><div>We previously identified the trimethylsulfonium ion (TMS) in human urine and highlighted its potential as a novel H<sub>2</sub>S biomarker but observed significant inter-individual variability in its urinary excretion. In this work we investigate the contribution of genetic factors to this variability in a group of European subjects (n = 100) from the BioPersMed cohort. Urinary TMS concentrations displayed two clusters within 5.0–20 nM and 100–400 nM. Genotyping revealed that this clustering is linked to a single nucleotide polymorphism (rs6970396) in the INMT gene, P < 0.001. We found strong contrast in the effects of rs6970396 between TMS and the selenium analogue TMSe which is one of many other detoxification products of the poorly recognized chalcogen-methylation activity of the INMT enzyme. Genetic variability in INMT has wide implications not only for the detoxification of H<sub>2</sub>S, both inhaled and naturally produced, but also for that of other volatile sulfur compounds in humans which may serve as substrates including xenobiotics.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104662"},"PeriodicalIF":4.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicity and bioaccumulation of nanoparticles of zinc oxide (ZnO) and titanium dioxide (TiO2) in Chydorus sphaericus and Cypridopsis cf. vidua (Crustacea)

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-02-22 DOI: 10.1016/j.etap.2025.104661

Miguel Hernández-Pedraza , Jesús Alvarado-Flores , Marcelo Silva-Briano , Araceli Adabache-Ortiz , Roberto Rico-Martínez

Nanoparticles of titanium dioxide (TiO₂) and zinc oxide (ZnO), have great demand and commercial use. Their presence in water reservoirs constitute a potential to produce adverse effects on crustaceans. We used two species of crustaceans: the cladoceran Chydorus sphaericus, and the ostracod Cypridopsis cf. vidua. Cultures were kept in a bioclimatic chamber at 20°C and 25°C respectively. Model organisms were exposed to the nanoparticles of TiO₂ and ZnO. We observed presence of nanoparticles in both organisms exposed to LC₅₀ values using X-ray diffraction. The nanoparticles of ZnO are the most toxic for both species than those of TiO₂. In cladocerans toxicity of TiO₂ nanoparticles decreased in the following order: anatase > anatase-rutilium > rutilium. In all cases LC₅₀ values of cladocerans are lower than those of ostracods. Titanium was detected in both external and internal structures. Titanium was more abundant in cladocerans than ostracods. However, zinc was not detected. We found differences in the elemental composition of cladocerans and ostracods after being exposed to both TiO₂ and ZnO. In ostracods we found more calcium whereas in cladocerans we found more carbon. We discussed these findings in terms of biochemical composition of both biological species and the toxicity of the nanoparticles.

{"title":"Toxicity and bioaccumulation of nanoparticles of zinc oxide (ZnO) and titanium dioxide (TiO2) in Chydorus sphaericus and Cypridopsis cf. vidua (Crustacea)","authors":"Miguel Hernández-Pedraza , Jesús Alvarado-Flores , Marcelo Silva-Briano , Araceli Adabache-Ortiz , Roberto Rico-Martínez","doi":"10.1016/j.etap.2025.104661","DOIUrl":"10.1016/j.etap.2025.104661","url":null,"abstract":"<div><div>Nanoparticles of titanium dioxide (TiO<sub>2</sub>) and zinc oxide (ZnO), have great demand and commercial use. Their presence in water reservoirs constitute a potential to produce adverse effects on crustaceans. We used two species of crustaceans: the cladoceran <em>Chydorus sphaericus</em>, and the ostracod <em>Cypridopsis</em> cf. <em>vidua</em>. Cultures were kept in a bioclimatic chamber at 20°C and 25°C respectively. Model organisms were exposed to the nanoparticles of TiO<sub>2</sub> and ZnO. We observed presence of nanoparticles in both organisms exposed to LC<sub>50</sub> values using X-ray diffraction. The nanoparticles of ZnO are the most toxic for both species than those of TiO<sub>2</sub>. In cladocerans toxicity of TiO<sub>2</sub> nanoparticles decreased in the following order: anatase > anatase-rutilium > rutilium. In all cases LC<sub>50</sub> values of cladocerans are lower than those of ostracods. Titanium was detected in both external and internal structures. Titanium was more abundant in cladocerans than ostracods. However, zinc was not detected. We found differences in the elemental composition of cladocerans and ostracods after being exposed to both TiO<sub>2</sub> and ZnO. In ostracods we found more calcium whereas in cladocerans we found more carbon. We discussed these findings in terms of biochemical composition of both biological species and the toxicity of the nanoparticles.</div></div>","PeriodicalId":11775,"journal":{"name":"Environmental toxicology and pharmacology","volume":"115 ","pages":"Article 104661"},"PeriodicalIF":4.2,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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