Environmental toxicology and pharmacology最新文献

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Evaluation of the ivermectin effects on porcine granulosa cell function 伊维菌素对猪颗粒细胞功能影响的评价

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-04-01 Epub Date: 2026-02-10 DOI: 10.1016/j.etap.2026.104960

Giuseppina Basini, Fausto Quintavalla, Simona Bussolati, Francesca Grasselli

Ivermectin (IVM) is used as antiparasitic drug in veterinary medicine and it is also the only avermectin approved in humans in several parasitic infestations. We examined this substance because potential critical issues associated with the use were highlighted. Moreover, criticisms related to the ecological-environmental sphere, as well as food contamination arise. Nevertheless, current in vitro studies are lacking. This study aimed to investigate the direct impact of IVM on reproductive function using swine granulosa cells as reproductive cell model. The results show that progesterone, ATP and free radicals’ levels significantly increased (p < 0.05). Non-enzymatic defense systems as well as autophagy did not show significant differences. On the contrary, cell proliferation, estradiol levels, and enzymatic defense systems significantly decreased (p < 0.05) after IVM treatment. Since results show that the normal function of these cells is compromised by IVM the normal reproductive functions of the entire organism could be disrupted.

伊维菌素（IVM）是兽医学中常用的抗寄生虫药物，也是在几种寄生虫感染中唯一被批准用于人类的阿维菌素。我们检查了这种物质，因为与使用相关的潜在关键问题得到了强调。此外，还出现了与生态环境领域以及食品污染有关的批评。然而，目前缺乏体外研究。本研究以猪颗粒细胞为生殖细胞模型，探讨IVM对猪生殖功能的直接影响。结果表明，黄体酮、ATP和自由基水平显著升高（p < 0.05）。非酶防御系统和自噬没有显著差异。相反，IVM处理后细胞增殖、雌二醇水平和酶防御系统显著降低（p < 0.05）。由于研究结果表明这些细胞的正常功能受到IVM的损害，整个生物体的正常生殖功能可能受到破坏。

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引用次数: 0

Selenium modulates the antioxidative response in green microalga Monoraphidium cf. contortum 硒调节绿微藻的抗氧化反应

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-04-01 Epub Date: 2026-02-09 DOI: 10.1016/j.etap.2026.104958

Dubravka Špoljarić Maronić , Ivna Štolfa Čamagajevac , Tanja Žuna Pfeiffer , Ana Pilipović , Nikolina Sabo , Nikolina Bek , Filip Stević , Ivana Maksimović , Anita Galir , Zdenko Lončarić

As algae are the main route of selenium (Se) transport from water to other consumers in food webs, the effect of selenite on the total Se content, growth, and antioxidant status of the unicellular green alga Monoraphidium cf. contortum was determined. The basal Se content (<3 mg/kg DW) was lower compared to other green microalgae, but the species showed a high accumulation potential (284.1 mg/kg DW). Despite early Se accumulation and growth inhibition, a significant loss of chlorophylls and carotenoids was observed only after 72 h. The response of antioxidative enzymes corresponded to a lower intensity of lipid peroxidation, despite increased ROS content at lower selenite concentrations. Primarily, selenite increased the activities of ascorbate peroxidase (APX), glutathione reductase, glutathione peroxidase (GPX), and glutathione S-transferase (GST), and inhibited catalase (CAT) in almost all treatments. Higher GST and GPX activities, as well as selenite-induced non-enzymatic glutathione (GSH) oxidation indicated increased GSH depletion.

由于藻类是食物网中硒从水中转运到其他消费者的主要途径，因此研究了亚硒酸盐对单细胞绿藻（Monoraphidium cf. contortum）总硒含量、生长和抗氧化状态的影响。其硒的基础含量（3mg/kg DW）低于其他绿微藻，但积累潜力较大（284.1mg/kg DW）。尽管早期硒积累和生长抑制，但仅在72小时后才观察到叶绿素和类胡萝卜素的显著损失。尽管亚硒酸盐浓度较低时ROS含量增加，但抗氧化酶的反应与较低强度的脂质过氧化反应相对应。在几乎所有处理中，亚硒酸盐增加了抗坏血酸过氧化物酶（APX）、谷胱甘肽还原酶、谷胱甘肽过氧化物酶（GPX）和谷胱甘肽s -转移酶（GST）的活性，抑制了过氧化氢酶（CAT）的活性。较高的GST和GPX活性，以及亚硒酸盐诱导的非酶促谷胱甘肽（GSH）氧化表明GSH消耗增加。

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引用次数: 0

Bisphenol S toxicity in zebrafish: Endocrine, neurobehavioural, and metabolic disruptions 斑马鱼的双酚S毒性：内分泌、神经行为和代谢紊乱

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-04-01 Epub Date: 2026-02-09 DOI: 10.1016/j.etap.2026.104959

A K M Munzurul Hasan , Som Niyogi , Douglas P. Chivers

Bisphenol S (BPS), increasingly used as a substitute for Bisphenol A, has raised toxicological concern due to its environmental persistence and widespread exposure. Zebrafish (Danio rerio) provides a valuable model for assessing BPS toxicity because of conserved endocrine and neural pathways, rapid development, and well-established behavioural assays. This review synthesizes current evidence on the effects of BPS exposure in zebrafish. Available studies indicate that BPS is associated with alterations in multiple endocrine axes, including the hypothalamic-pituitary-gonadal, thyroid, and interrenal axes, with consequences for reproduction, thyroid hormone signaling, and stress regulation. Neurobehavioural alterations are frequently reported and are linked to oxidative stress, apoptosis, neurotransmitter imbalance, and isotocinergic or vasotocinergic dysregulation. Additional evidence associates BPS exposure with metabolic, cardiovascular, and immune alterations, including hepatic lipid accumulation, glucose dysregulation, vascular dysfunction, impaired myelopoiesis, inflammatory signaling, and gut microbial imbalance. Finally, this review highlights key knowledge gaps for future research.

双酚S （BPS）越来越多地被用作双酚a的替代品，由于其在环境中的持久性和广泛暴露，引起了人们对其毒理学的关注。斑马鱼（Danio rerio）为评估BPS毒性提供了一个有价值的模型，因为它具有保守的内分泌和神经通路，快速发育和完善的行为分析。本文综述了目前有关BPS暴露对斑马鱼影响的证据。现有研究表明，BPS与多种内分泌轴的改变有关，包括下丘脑-垂体-性腺、甲状腺和肾间系统，对生殖、甲状腺激素信号传导和应激调节产生影响。神经行为改变经常被报道，并与氧化应激、细胞凋亡、神经递质失衡、等同化能或血管同化能失调有关。其他证据表明BPS暴露与代谢、心血管和免疫改变有关，包括肝脂质积累、葡萄糖失调、血管功能障碍、骨髓生成受损、炎症信号和肠道微生物失衡。最后，本综述确定了未来研究的关键知识空白。

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引用次数: 0

Activation of the MKK4/7-JNK-c-Jun axis mediates Bisphenol F-induced neurodegeneration and behavioural alteration in adult zebrafish MKK4/7-JNK-c-Jun轴的激活介导双酚f诱导的成年斑马鱼神经变性和行为改变

IF 4.3 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-03-21 DOI: 10.1016/j.etap.2026.105003

Suvam Bhoi, Prerana Sarangi, Lilesh Kumar Pradhan, Pradyumna Kumar Sahoo, Bhabani Sankar Sahoo, Saroj Kumar Das

引用次数: 0

Nuclear and cytoskeletal structural alterations in human alveolar epithelial cells by solvent-extracted organic matter from PM2.5 PM2.5中溶剂提取有机物对人肺泡上皮细胞核和细胞骨架结构的影响

IF 4.3 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-03-21 DOI: 10.1016/j.etap.2026.104996

Octavio Ispanixtlahuatl-Meraz, Alejandro Déciga-Alcaraz, Marisela Uribe-Ramírez, Josefina Poblano-Bata, Andrea De Vizcaya-Ruiz, Omar Amador-Muñoz, Yolanda I. Chirino

引用次数: 0

Seafood-Based Dietary Cadmium Exposure Triggers Physiological Stress and Gene Dysregulation in Zebrafish 以海产品为基础的饮食镉暴露引发斑马鱼生理应激和基因失调

IF 4.3 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-03-21 DOI: 10.1016/j.etap.2026.105002

Arumugam Yogeshwaran, Madhavan Subashchandrabose, Krishnan Anandhan, Said Hamid Thangal, Thirunavukkarasu Muralisankar

引用次数: 0

Metabolic pathway modulation and oxidative imbalance triggered by decamethylcyclopentasiloxane (D5) in zebrafish embryo 十甲基环戊硅氧烷（D5）引发斑马鱼胚胎代谢途径调控及氧化失衡

IF 4.3 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-03-21 DOI: 10.1016/j.etap.2026.105005

Ítalo B.L Andrade, Lílian C Pereira, Carla Quintaneiro, Amadeu M.V.M Soares, Marta S Monteiro

引用次数: 0

Gene expression signatures of honey bee brood reveal immune stimulation and nutritional trade-offs under oxalic acid treatment and chalkbrood disease 基因表达特征揭示了草酸处理和白垩病下的免疫刺激和营养权衡

IF 4.3 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-03-20 DOI: 10.1016/j.etap.2026.105001

Eliška Beranová, Silvie Dostálková, Marek Petřivalský, Per Kryger, Jiří Danihlík

Varroa destructor is the most significant pest of honey bees worldwide, and oxalic acid (OA) is widely used for its control. However, its effects on brood physiology remain unclear. We examined the impact of oxalic acid-glycerine (OA-G) strips and chalkbrood (Ascosphaera apis) infection on gene expression in Apis mellifera prepupae. Twelve colonies were assigned to control, OA-G, A. apis, and combined OA-G + A. apis groups. Gene expression of antimicrobial peptides (AmPs), vitellogenin (Vg), and Vg-like B was analyzed seven days post-treatment using RT-qPCR. OA-G treatment significantly upregulated defensin1 and hymenoptaecin in both healthy and infected brood, indicating strong immune activation. In contrast, abaecin was downregulated, while apidaecin increased only under infection. Vitellogenin was consistently suppressed across all treatments, whereas Vg-like B remained unchanged. These results demonstrate differential immune and nutritional trade-offs in brood following OA exposure and infection, underscoring the complex physiological consequences of varroosis management.

瓦螨是世界范围内危害蜜蜂最严重的害虫，草酸被广泛用于其防治。然而，其对雏鸟生理的影响尚不清楚。研究草酸甘油（OA-G）条和白垩菌（Ascosphaera apis）感染对蜜蜂预蛹基因表达的影响。12个菌落分为对照组、OA-G组、a - g组和OA-G + a - api组合组。使用RT-qPCR分析治疗后7天抗菌肽（AmPs）、卵黄蛋白原（Vg）和卵黄蛋白样B的基因表达。OA-G处理显著上调了健康和感染雏鸟的防御素1和膜蜂素，表明有很强的免疫激活作用。相比之下，abaecin被下调，而apidaecin仅在感染下升高。在所有处理中，卵黄原蛋白一直受到抑制，而vg样B保持不变。这些结果表明，在OA暴露和感染后，雏鸟的免疫和营养权衡存在差异，强调了静脉曲张管理的复杂生理后果。

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引用次数: 0

Blood lead and lung function in Danish solid-waste incineration workers: A cross-sectional study 丹麦固体废物焚烧工人的血铅和肺功能：一项横断面研究

IF 4.3 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-03-14 DOI: 10.1016/j.etap.2026.104995

Sofie Juul Fulton, Jonas Christian Lunen, Stinna Skaaby, Poul Frost

Danish solid-waste incineration workers may be exposed to dust, containing metals including lead. While negative implications of higher levels of lead and dust exposure are well established, the health effects of contemporary low-level exposure remain unclear. This cross-sectional biomonitoring study among 55 male incineration workers compared blood lead levels and FEV₁ between 31 dusty-task workers and 24 controls using multivariable regression. None of the participants had blood lead exceeding the Danish upper reference value (<0.53 µmol/L). Workers exposed to dusty tasks (n=31) had higher blood lead and a 2.1-fold higher prevalence of blood lead ≥0.1 µmol/L compared to controls. FEV₁ was lower in exposed workers (3.5L; 90% predicted) compared to controls (4.2L; 102% predicted), but this difference was non-significant after adjustment for confounders. Findings indicate persistent low-level lead exposure in Danish solid-waste incineration settings, underscoring the need for continued exposure controls and proper use of personal protective equipment.

丹麦固体废物焚烧工人可能接触到含有铅等金属的粉尘。虽然较高水平的铅和粉尘接触的负面影响已得到充分确认，但当代低水平接触对健康的影响仍不清楚。本研究采用多变量回归方法，对55名男性焚烧工人的血铅水平和FEV 1进行了横断面生物监测研究，比较了31名粉尘作业工人和24名对照者的血铅水平和FEV 1。没有参与者的血铅超过丹麦最高参考值（0.53µmol/L）。与对照组相比，暴露于粉尘作业的工人（n=31）血铅较高，血铅≥0.1µmol/L的患病率高2.1倍。与对照组（4.2L，预测为102%）相比，暴露工人的FEV 1 （3.5L，预测为90%）较低，但在调整混杂因素后，这种差异不显着。调查结果表明，在丹麦固体废物焚烧环境中持续存在低水平铅暴露，强调需要继续控制暴露并正确使用个人防护设备。

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引用次数: 0

MicroRNA-mediated disruption of testosterone signaling associated with e-cigarette exposure 微rna介导的与电子烟暴露相关的睾酮信号中断

IF 4.3 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-03-13 DOI: 10.1016/j.etap.2026.104994

Ardie Barry Sailis, Muhamad Alfakri Mat Noh, Leo Bey Fen, Farid Nazer Faruqu, Anne Yee, Sim Maw Shin

引用次数: 0

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