Unveiling stress markers: A systematic review investigating psychological stress biomarkers

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-29 DOI:10.1002/dev.22490

Khushi Shah, Ruchi Kumari, Mukul Jain

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Abstract

Psychological stress is a ubiquitous facet of modern life, impacting individuals across diverse contexts and demographics. Understanding its physiological manifestations through biomarkers has gained substantial attention within the scientific community. A comprehensive search was conducted across multiple databases for peer-reviewed articles published within the past decade. Preliminary findings reveal many biomarkers associated with psychological stress across different biological systems, including the hypothalamic–pituitary–adrenal axis, immune system, cardiovascular system, and central nervous system. This systematic review explores psychological, physiological, and biochemical biomarkers associated with stress. Analyzing recent literature, it synthesizes findings across these three categories, elucidating their respective roles in stress response mechanisms. Psychological markers involve subjective assessments like self-reported stress levels, perceived stress scales, or psychometric evaluations measuring anxiety, depression, or coping mechanisms. Physiological markers include heart rate variability, blood pressure, and immune system responses such as cytokine levels or inflammatory markers. Biochemical markers involve hormones or chemicals linked to stress. It includes cortisol, catecholamines, copeptin, salivary amylase, IL-6, and C-reactive protein.

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揭开压力标志物的面纱：调查心理压力生物标志物的系统综述

心理压力是现代生活中无处不在的一个方面，影响着不同背景和人口的个体。通过生物标志物来了解其生理表现已引起科学界的极大关注。我们在多个数据库中对过去十年间发表的同行评审文章进行了全面搜索。初步研究结果显示，许多生物标记物与不同生物系统中的心理压力有关，包括下丘脑-垂体-肾上腺轴、免疫系统、心血管系统和中枢神经系统。本系统综述探讨了与压力相关的心理、生理和生化生物标志物。通过分析最近的文献，它综合了这三类指标的研究结果，阐明了它们在压力反应机制中各自的作用。心理标志物涉及主观评估，如自我报告的压力水平、感知压力量表或测量焦虑、抑郁或应对机制的心理评估。生理指标包括心率变异、血压和免疫系统反应，如细胞因子水平或炎症指标。生化指标涉及与压力有关的激素或化学物质。它包括皮质醇、儿茶酚胺、 copeptin、唾液淀粉酶、IL-6 和 C 反应蛋白。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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