Mechanism of Peptide Self-assembly and Its Study in Biomedicine

IF 1.9 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY The Protein Journal Pub Date : 2024-04-27 DOI:10.1007/s10930-024-10200-5
Xinyue Yang, Li Ma, Kui Lu, Dongxin Zhao
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Abstract

The development of peptide-based materials is one of the most challenging aspects of biomaterials research in recent years. The assembly of peptides is mainly controlled by forces such as hydrogen bonding, hydrophobic interaction, electrostatic interaction, and π-π accumulation. Peptides have unique advantages such as simple structure, easy synthesis, good biocompatibility, non-toxicity, easy modification, etc. These factors make peptides turn into ideal biomedical materials, and they have a broad application prospect in biomedical materials, and thus have received wide attention. In this review, the mechanism and classification of peptide self-assembly and its applications in biomedicine and hydrogels were introduced.

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多肽自组装机制及其在生物医学中的研究
肽基材料的开发是近年来生物材料研究领域最具挑战性的课题之一。肽的组装主要受氢键作用、疏水作用、静电作用和π-π堆积等力的控制。多肽具有结构简单、易于合成、生物相容性好、无毒、易修饰等独特优势。这些因素使多肽成为理想的生物医学材料,在生物医学材料领域具有广阔的应用前景,因而受到广泛关注。本综述介绍了多肽自组装的机理、分类及其在生物医学和水凝胶中的应用。
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来源期刊
The Protein Journal
The Protein Journal 生物-生化与分子生物学
CiteScore
5.20
自引率
0.00%
发文量
57
审稿时长
12 months
期刊介绍: The Protein Journal (formerly the Journal of Protein Chemistry) publishes original research work on all aspects of proteins and peptides. These include studies concerned with covalent or three-dimensional structure determination (X-ray, NMR, cryoEM, EPR/ESR, optical methods, etc.), computational aspects of protein structure and function, protein folding and misfolding, assembly, genetics, evolution, proteomics, molecular biology, protein engineering, protein nanotechnology, protein purification and analysis and peptide synthesis, as well as the elucidation and interpretation of the molecular bases of biological activities of proteins and peptides. We accept original research papers, reviews, mini-reviews, hypotheses, opinion papers, and letters to the editor.
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