Discovery of PSMA in the prostate of the common marmoset (Callithrix jacchus)

The Prostate Pub Date : 2024-04-28 DOI:10.1002/pros.24722
Diane E. Peters, Michael Brownlee, Donna Layne‐Colon, Barbara S. Slusher
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Abstract

BackgroundProstate‐specific membrane antigen (PSMA) is a biomarker and therapeutic target of high relevance in prostate cancer. Although upregulated PSMA expression is a well‐documented feature of prostatic neoplasia in both humans and canids, to date humans are the only species known to express PSMA basally in the prostate. Thus, traditional laboratory animal species have limited utility for studying PSMA biology in the prostate or for predicting efficacy or toxicity of PSMA‐targeted agents.MethodsPSMA expression in human, macaque, and marmoset prostates was determined by immunohistochemistry, employing an antibody with validated cross‐species reactivity in a PSMA‐positive control tissue; kidney.ResultsWe newly discover that the common marmoset endogenously expresses PSMA in non‐diseased prostate, similar to humans, and thus may be a valuable preclinical model for researchers studying PSMA.
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在普通狨猴前列腺中发现 PSMA
背景前列腺特异性膜抗原(PSMA)是与前列腺癌高度相关的生物标志物和治疗靶点。尽管PSMA表达上调是人类和犬科动物前列腺肿瘤的一个有据可查的特征,但迄今为止,人类是唯一已知在前列腺中基本表达PSMA的物种。因此,传统的实验动物物种在研究前列腺中 PSMA 的生物学特性或预测 PSMA 靶向药物的疗效或毒性方面作用有限。结果我们新近发现,普通狨猴在未患病的前列腺中内源性表达 PSMA,与人类相似,因此可能是研究 PSMA 的研究人员的一个有价值的临床前模型。
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