A High-Resolution Portable Gamma-Camera for Estimation of Absorbed Dose in Molecular Radiotherapy

IF 4.6 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2024-03-13 DOI:10.1109/TRPMS.2024.3376826
T. Bossis;M.-A. Verdier;C. Trigila;L. Pinot;F. Bouvet;A. Blot;H. Ramarijaona;T. Beaumont;D. Broggio;O. Caselles;S. Zerdoud;L. Ménard
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Abstract

Molecular radiotherapy is a treatment modality that requires personalized dosimetry for efficient treatment and reduced toxicity. Current clinical imaging systems and miniaturized gamma-cameras lack the necessary features for this task. In this article, we present the design and optimization of a mobile gamma-camera with a $10\times 10$ cm2 field of view tailored for quantitative imaging during $^{131}\text{I}$ therapy of thyroid diseases. The camera uses a monolithic $10\times 10\times 1$ cm3 CeBr3 scintillator coupled to a $16\times 16$ SiPMs array and commercial electronics. It exhibits high imaging performance with an intrinsic spatial resolution (SR) of 1.15-mm FWHM, an energy resolution of 8% FWHM at 356 keV and negligible deadtime up to 150 kcps. Images are reconstructed in real time using a convolutional neural network. The manufacturing method of tungsten collimators and shielding was optimized using laser 3-D printing to achieve an effective density of 97% that of bulk tungsten. Their geometry was adjusted with Monte-Carlo simulations in order to reduce septal penetration and scattering and optimize the signal-to-noise ratio at short times after treatment administration. Two high-energy parallel-hole collimators with high sensitivity or very high SR were designed for treatment planning and post-treatment control. The fully operational gamma-camera will soon be clinically assessed.
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用于估算分子放射治疗吸收剂量的高分辨率便携式伽马相机
分子放射治疗是一种需要个性化剂量测定的治疗方式,以实现高效治疗和减少毒性。目前的临床成像系统和微型伽马相机缺乏完成这项任务的必要功能。在这篇文章中,我们介绍了一种移动式伽马相机的设计和优化,它的视场为10美元/10平方厘米,专门用于甲状腺疾病的^{131}\text{I}$治疗过程中的定量成像。该相机使用了一个10美元/次 10美元/次 1立方厘米的单片CeBr3闪烁体,该闪烁体与一个16美元/次 16美元的SiPMs阵列和商用电子设备相连。它具有很高的成像性能,固有空间分辨率(SR)为 1.15 mm FWHM,在 356 keV 时的能量分辨率为 8% FWHM,死区时间可忽略不计,最高可达 150 kcps。使用卷积神经网络实时重建图像。钨准直器和屏蔽的制造方法通过激光三维打印进行了优化,使其有效密度达到块状钨的 97%。通过蒙特卡洛模拟调整了它们的几何形状,以减少隔膜穿透和散射,优化治疗后短时间内的信噪比。设计了两个高能量平行孔准直器,具有高灵敏度或极高的 SR,用于治疗计划和治疗后控制。全面运行的伽马相机不久将进行临床评估。
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来源期刊
IEEE Transactions on Radiation and Plasma Medical Sciences
IEEE Transactions on Radiation and Plasma Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
8.00
自引率
18.20%
发文量
109
期刊最新文献
Affiliate Plan of the IEEE Nuclear and Plasma Sciences Society Table of Contents IEEE Transactions on Radiation and Plasma Medical Sciences Information for Authors IEEE Transactions on Radiation and Plasma Medical Sciences Publication Information Three-Gamma Imaging in Nuclear Medicine: A Review
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