{"title":"A High-Resolution Portable Gamma-Camera for Estimation of Absorbed Dose in Molecular Radiotherapy","authors":"T. Bossis;M.-A. Verdier;C. Trigila;L. Pinot;F. Bouvet;A. Blot;H. Ramarijaona;T. Beaumont;D. Broggio;O. Caselles;S. Zerdoud;L. Ménard","doi":"10.1109/TRPMS.2024.3376826","DOIUrl":null,"url":null,"abstract":"Molecular radiotherapy is a treatment modality that requires personalized dosimetry for efficient treatment and reduced toxicity. Current clinical imaging systems and miniaturized gamma-cameras lack the necessary features for this task. In this article, we present the design and optimization of a mobile gamma-camera with a \n<inline-formula> <tex-math>$10\\times 10$ </tex-math></inline-formula>\n cm2 field of view tailored for quantitative imaging during \n<inline-formula> <tex-math>$^{131}\\text{I}$ </tex-math></inline-formula>\n therapy of thyroid diseases. The camera uses a monolithic \n<inline-formula> <tex-math>$10\\times 10\\times 1$ </tex-math></inline-formula>\n cm3 CeBr3 scintillator coupled to a \n<inline-formula> <tex-math>$16\\times 16$ </tex-math></inline-formula>\n SiPMs array and commercial electronics. It exhibits high imaging performance with an intrinsic spatial resolution (SR) of 1.15-mm FWHM, an energy resolution of 8% FWHM at 356 keV and negligible deadtime up to 150 kcps. Images are reconstructed in real time using a convolutional neural network. The manufacturing method of tungsten collimators and shielding was optimized using laser 3-D printing to achieve an effective density of 97% that of bulk tungsten. Their geometry was adjusted with Monte-Carlo simulations in order to reduce septal penetration and scattering and optimize the signal-to-noise ratio at short times after treatment administration. Two high-energy parallel-hole collimators with high sensitivity or very high SR were designed for treatment planning and post-treatment control. The fully operational gamma-camera will soon be clinically assessed.","PeriodicalId":46807,"journal":{"name":"IEEE Transactions on Radiation and Plasma Medical Sciences","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10472319","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Transactions on Radiation and Plasma Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://ieeexplore.ieee.org/document/10472319/","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Molecular radiotherapy is a treatment modality that requires personalized dosimetry for efficient treatment and reduced toxicity. Current clinical imaging systems and miniaturized gamma-cameras lack the necessary features for this task. In this article, we present the design and optimization of a mobile gamma-camera with a
$10\times 10$
cm2 field of view tailored for quantitative imaging during
$^{131}\text{I}$
therapy of thyroid diseases. The camera uses a monolithic
$10\times 10\times 1$
cm3 CeBr3 scintillator coupled to a
$16\times 16$
SiPMs array and commercial electronics. It exhibits high imaging performance with an intrinsic spatial resolution (SR) of 1.15-mm FWHM, an energy resolution of 8% FWHM at 356 keV and negligible deadtime up to 150 kcps. Images are reconstructed in real time using a convolutional neural network. The manufacturing method of tungsten collimators and shielding was optimized using laser 3-D printing to achieve an effective density of 97% that of bulk tungsten. Their geometry was adjusted with Monte-Carlo simulations in order to reduce septal penetration and scattering and optimize the signal-to-noise ratio at short times after treatment administration. Two high-energy parallel-hole collimators with high sensitivity or very high SR were designed for treatment planning and post-treatment control. The fully operational gamma-camera will soon be clinically assessed.