A High-Resolution Portable Gamma-Camera for Estimation of Absorbed Dose in Molecular Radiotherapy

IF 4.6 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING IEEE Transactions on Radiation and Plasma Medical Sciences Pub Date : 2024-03-13 DOI:10.1109/TRPMS.2024.3376826
T. Bossis;M.-A. Verdier;C. Trigila;L. Pinot;F. Bouvet;A. Blot;H. Ramarijaona;T. Beaumont;D. Broggio;O. Caselles;S. Zerdoud;L. Ménard
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Abstract

Molecular radiotherapy is a treatment modality that requires personalized dosimetry for efficient treatment and reduced toxicity. Current clinical imaging systems and miniaturized gamma-cameras lack the necessary features for this task. In this article, we present the design and optimization of a mobile gamma-camera with a $10\times 10$ cm2 field of view tailored for quantitative imaging during $^{131}\text{I}$ therapy of thyroid diseases. The camera uses a monolithic $10\times 10\times 1$ cm3 CeBr3 scintillator coupled to a $16\times 16$ SiPMs array and commercial electronics. It exhibits high imaging performance with an intrinsic spatial resolution (SR) of 1.15-mm FWHM, an energy resolution of 8% FWHM at 356 keV and negligible deadtime up to 150 kcps. Images are reconstructed in real time using a convolutional neural network. The manufacturing method of tungsten collimators and shielding was optimized using laser 3-D printing to achieve an effective density of 97% that of bulk tungsten. Their geometry was adjusted with Monte-Carlo simulations in order to reduce septal penetration and scattering and optimize the signal-to-noise ratio at short times after treatment administration. Two high-energy parallel-hole collimators with high sensitivity or very high SR were designed for treatment planning and post-treatment control. The fully operational gamma-camera will soon be clinically assessed.
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用于估算分子放射治疗吸收剂量的高分辨率便携式伽马相机
分子放射治疗是一种需要个性化剂量测定的治疗方式,以实现高效治疗和减少毒性。目前的临床成像系统和微型伽马相机缺乏完成这项任务的必要功能。在这篇文章中,我们介绍了一种移动式伽马相机的设计和优化,它的视场为10美元/10平方厘米,专门用于甲状腺疾病的^{131}\text{I}$治疗过程中的定量成像。该相机使用了一个10美元/次 10美元/次 1立方厘米的单片CeBr3闪烁体,该闪烁体与一个16美元/次 16美元的SiPMs阵列和商用电子设备相连。它具有很高的成像性能,固有空间分辨率(SR)为 1.15 mm FWHM,在 356 keV 时的能量分辨率为 8% FWHM,死区时间可忽略不计,最高可达 150 kcps。使用卷积神经网络实时重建图像。钨准直器和屏蔽的制造方法通过激光三维打印进行了优化,使其有效密度达到块状钨的 97%。通过蒙特卡洛模拟调整了它们的几何形状,以减少隔膜穿透和散射,优化治疗后短时间内的信噪比。设计了两个高能量平行孔准直器,具有高灵敏度或极高的 SR,用于治疗计划和治疗后控制。全面运行的伽马相机不久将进行临床评估。
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来源期刊
IEEE Transactions on Radiation and Plasma Medical Sciences
IEEE Transactions on Radiation and Plasma Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
8.00
自引率
18.20%
发文量
109
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Affiliate Plan of the IEEE Nuclear and Plasma Sciences Society Table of Contents Introducing IEEE Collabratec IEEE Transactions on Radiation and Plasma Medical Sciences Publication Information Member Get-a-Member (MGM) Program
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