虽然非酒精性脂肪肝（NAFLD）通常与肥胖有关，但越来越多的非酒精性脂肪肝患者体重指数正常。与患有非酒精性脂肪肝的肥胖患者相比，患有非酒精性脂肪肝的瘦弱患者的糖尿病、高血压、高甘油三酯血症和代谢综合征发病率较低，但纤维化评分和心血管发病率较高。需要利用相关实验模型进行新的研究，以了解导致该人群心脏异常的机制，并指导疗法的开发。一项新的研究利用瘦型非酒精性脂肪肝遗传小鼠模型，证明了雌性和雄性小鼠在瘦型非酒精性脂肪肝进展和心血管并发症方面的差异。众所周知，Lrpprc基因敲除（KO）小鼠在没有肥胖的情况下也会发生线粒体肝病，这种小鼠的肝脏结构损伤和肝细胞损伤与性别无关。然而，考虑到肝脏炎症、葡萄糖代谢和心脏舒张功能的改变，KO 雄性小鼠表现出更严重的表型：Burelle, C. et al.7, 356 (2024)
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